I assume this general formula works for all benzo's?
Bit more info on receptor recovery below which is a factor for the halflife, which is interesting because the was I read it it's more than just half life elimination, I think you also need to wait for your receptors to recover after that or the lack of returning to baseline will cause your system to adapt to a higher GABA-A level, meaning you'll need/want/think about having Xanax just to feel normal even if you wait for it to fully leave your system. You also need to take account of YMMV etc. Also repeated use has an effect, and timing of it does too, you can gradually build up plasma levels overtime even with longer breaks that you would expect
So I think the number would be more like 5.3 days for halflife + 5.5 days receptor recovery so average 11 to 12 days - note this is the average
and to also add some more info on receptors to help illustrate what you need to consider how each benzo effects your body
| Primary receptor / target | Drug | Exposure assumption | Drug elimination range | Elimination average days | Receptor adaptation recovery after elimination range | Receptor recovery average days after elimination | Total receptor recovery from last dose range | Total receptor recovery average days | Hormone/endocrine effects | Hormone recovery after elimination range | Hormone recovery average days | Total hormone recovery from last dose range | Total hormone recovery average days | Evidence confidence | Evidence type | Notes / supporting papers | Recovery index score (0-100) | Receptor adaptation severity score (0-100) | Neuroadaptation type | Confidence weighted recovery estimate (days) |
| | | | | | | | | | | | | | | | | | | | |
| GABA-A | Diazepam | Single dose | 2-5 days | 3.5 | Minimal adaptation to several days | 2 | 3-7 days | 5.5 | Minimal direct hormonal effect | 1-3 days | 2 | 3-7 days | 5.5 | Medium | Human benzodiazepine pharmacokinetic studies | Long half-life contributes to total recovery time | 15 | 20 | Receptor modulation | 4 |
| GABA-A | Alprazolam | Single dose | 1-3 days | 2 | Minimal adaptation to several days | 2 | 2-5 days | 4 | Minimal direct hormonal effect | 1-3 days | 2 | 2-5 days | 4 | Medium | Human benzodiazepine studies | Short acting benzodiazepine with rapid clearance | 15 | 25 | Receptor modulation | 3 |
| GABA-A | Clonazepam | Single dose | 3-6 days | 4.5 | Minimal adaptation to several days | 2 | 5-10 days | 6.5 | Minimal direct hormonal effect | 1-3 days | 2 | 5-10 days | 6.5 | Medium | Human pharmacokinetic studies | Long half-life delays clearance | 15 | 20 | Receptor modulation | 5 |
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/208866
