Opioids 7-hydroxymitragynine (7-OH): Tolerance and Withdrawal timeline?

[jensmens69]

Hi everyone,

I am currently visiting the United States for 5 weeks and am considering purchasing either 420mg or 1,400mg of 7-hydroxymitragynine (7-OH) to use during my stay. Because of my travel plans, I will not be using it for longer than these 5 weeks.

I have no prior opioid dependencies and have never used opioids for a prolonged period. I have a few specific questions regarding tolerance and withdrawal (WD):

• Withdrawal Risk: Given that I have no prior opioid tolerance, would finishing either of these amounts (420mg or 1,400mg) within a 5-week window be enough to cause withdrawal symptoms when I stop? Is it possible to consume these amounts over 5 weeks and quit cold turkey without experiencing WDs?
• Tolerance Onset: How quickly does tolerance to 7-OH typically build up? Around how many milligrams or consecutive days of use does it usually take before a tolerance starts to form?

I appreciate any insights, personal experiences, or advice you can share.

Thanks in advance for your answers!

 

[chippermonk]

I don't honestly know the answer, having never having done 7oh other than a few times at very low dose ( I have done kratom itself quite a bit, though no addiction). But I would ask why you want to do this? What's your purpose and intent? Planning to take it daily?
If you have never really had an opioid habit then why bother? It ain't all that. It might be nice to take a small dose a couple times on your trip ( and start at 5 mg max imho), but taking often and high doses is just a waste of your mental and physical health.
Yes, I think you might get an addiction in that much time and taking that much, at least from what others have said. Likewise, tolerance builds up fast. So why purposely do that? Enjoy your time here in other more productive ways. If you are here on vacation then get your pleasure from that.
Happy trails!

 

[Featherfall]

yes

 

[thurston]

you're planning way too hard. There is no need to buy a bunch upfront, just go to a gas station or vape shop when you want some and take it. Have you made sure it's legal in the state you're going to?

 

[PtahTek]

imo 7-oh is way too available in the usa. it will only create more of an issue. the 7-oh will probably turn out one day to be fent just to add to the dependance. they put it in everything else, so....

if ya have no opioid tolerance why not just get a kg of leaf kratom -powder- and start with maybe 1/2 - 1g of kratom at first > give it about and hour. ive seen it work wonders for many things for many people with no tolerance.
in 5 weeks yes you will more than likely build a dependance that could possibly lead to some protracted, debilitating and agonizing withdrawals. i wouldnt recommend it, bud. a heads up. take a look through the 7-oh threads here.... not pretty.

if ya try kratom leaf; when ya done there may be a few "off" feeling days but life will go on.
be safe
dont get anything off the streets
if ya try anything start low dose - again, you cannalway increase the frequency if necessary.
try to keep usage to two times a week or less and never two days in a row - possibly a key to responsible usage and avoidance of withdrawals in genera<- thanks to @Keif' Richards
for the coinage of this.
on another note always check for bedbugs

it'll be a nice trip as posted live in the moment, stay expectant and be aware.
peace

 

[Didgital]

either 420mg or 1,400mg of 7-hydroxymitragynine

Such weird and precise quantities. I'm assuming you're planning on buying a particular branded product.

It's a potent molecule. With zero tolerance 5mg im definitely feeling it, and 15mg is too much for me. With tolerance (which develops pretty quickly imo) I can take a lot more, like 25mg is equivalent to 5mg a few weeks ago sorta thing. So, even 420mg to an opioid naive person is a fair amount of doses.

If you're taking ANY opioid every day for weeks there is a risk of becoming dependent which is when your body essentially "forgets" how to manufacture it's own endogenous opioids. When you stop taking exogenous opioids, the body freaks out and goes into withdrawl - From what I hear, withdrawl from 7-OH is worse than WD from heroin.

As far as onset of tolerance, it's quick, but is also highly dependent on your dosage and frequency of use. If you're using everyday, expect significant tolerance within a week. I was able to keep my tolerance low by only using it once maybe twice a week.

I personally did use A LOT of 7-OH over the period of a month and then just stopped cold turkey with no issues, but I consider myself lucky and an outlier. I was playing with fire, and I think you are too tbh.

Out of the two options, I'd get 420mg. Say a dose is 10mg (for perfectly naive people thats probably enough). 1400mg/10mg = 140 doses. If you're only going to be here 35 days you'd have to take that dose 4x a day to get through it all, which i think is a recipe for dependence...

you're planning way too hard. There is no need to buy a bunch upfront, just go to a gas station or vape shop when you want some and take it. Have you made sure it's legal in the state you're going to?

Agreed that OP is planning too hard, but I tend to think he's been eyeing specific products due to the very specific quantities he mentioned getting. I do think it's weird/bad harm reduction to actually encourage people to buy gas station drugs though. If I was going to use 7, I would order it from a reputable company and not just buy some random thing on the counter.

 

[Didgital]

I don't always see eye to eye with @PtahTek but I mostly agree with him on this. The plant is way less risky and probably a lot more affordable.

I do find the effects of kratom however to be a bit different than either pure Mitragynine (my preferred) or 7-OH (which most people say is VERY similar to morphine).
Kratom I get both stimulating and sedating effects and I presume it's due to the presence of other alkaloids. Sometimes, especially if I take too much, I feel pretty sick. I dunno. Powdered kratom to me is less predictable.
I've taken up to 250mg of pure MIT (Not extract, which is almost always a mix of alkaloids) and that is very smooth, euphoric and relaxing no nausea/vertigo and has a very slight rolly feeling.
7-OH was euphoric the first few times I took it, but it lost it really quick and just became a strong opioid.

I still think 7-OH is probably a safer alternative to other pain meds, but if you don't NEED it, maybe wise to avoid using it with any regularity.

 

[chippermonk]

Agreeing with what some others here are saying, just go with the powder kratom leaf ( no extracts). First time go with 1 tsp ( approx 2.5 g). See how that feels, go up slow because too much at first can cause nausea. It's actually pretty good when you first start. Nice bit of stimulation is part of it. You can't get into major trouble with it in that much time.
But I'd still humbly suggest not doing even kratom leaf more than 2 or 3 times a week. It just isn't necessary, unless perhaps you have a pain issue.
Where are you visiting anyhow and where are you from? , if you don't mind me asking ( just friendly curiosity, I like travel myself)

 

[PtahTek]

I don't always see eye to eye

i usually do not agree with myself. maybe its projection. idk
no ill intent, see. we all need space. trying to breathe atm and walls are closing in. alice in wonderland i feel i have outgrown this box.
derailed....
peace

ot.
can this 7-oh be tapered? any success stories? if not that really blows.
i really dont wanna get into 7-oh but the junkie in me wants to run to the store and grab a bottle just for the *experience.

if its able to be titrated that would be my suggestion to start.lile any other substance one would need to be in the range of dosage to be able to transition to anything else. just my opinion from a little experience. not sure if buprenorphine helps with wds from these extractions or whatever they are. dont think it does from what i have read just here at bl.
whattaya do...?

 

[Featherfall]

not sure if buprenorphine helps with wds from these extractions or whatever they are. dont think it does from what i have read just here at bl.
whattaya do...?

nope, not consistently at all, its very weird, wouldnt risk it

 

[AlwaysHasBeen]

Hi everyone,

I am currently visiting the United States for 5 weeks and am considering purchasing either 420mg or 1,400mg of 7-hydroxymitragynine (7-OH) to use during my stay. Because of my travel plans, I will not be using it for longer than these 5 weeks.

I have no prior opioid dependencies and have never used opioids for a prolonged period. I have a few specific questions regarding tolerance and withdrawal (WD):

• Withdrawal Risk: Given that I have no prior opioid tolerance, would finishing either of these amounts (420mg or 1,400mg) within a 5-week window be enough to cause withdrawal symptoms when I stop? Is it possible to consume these amounts over 5 weeks and quit cold turkey without experiencing WDs?
• Tolerance Onset: How quickly does tolerance to 7-OH typically build up? Around how many milligrams or consecutive days of use does it usually take before a tolerance starts to form?

I appreciate any insights, personal experiences, or advice you can share.

Thanks in advance for your answers!

Just do not, go find fetty or painkillers because I promise you the withdrawel is the same so if you are gonna torture yourself with a drug, mine as well go all the way. Sorry you feel you need a drug to experience America, you should not.

 

[Syntherize]

You have zero tolerance and you want to jump right into 7-OH like that? Don’t be a fool! Go order a kilo of quality red vein kratom from a place like Golden Monk and just carry that around with you. You’ll be better off and experience better results. Also, don’t forget to check the local laws in the state and city you will be visiting because there are like five jurisdictions in the USA where it is outright banned and/or 7-OH and MGM-15 are such as the recent move in Florida’s kratom laws pertaining 7-OH.

 

[Didgital]

You have zero tolerance and you want to jump right into 7-OH like that? Don’t be a fool! Go order a kilo of quality red vein kratom from a place like Golden Monk and just carry that around with you. You’ll be better off and experience better results. Also, don’t forget to check the local laws in the state and city you will be visiting because there are like five jurisdictions in the USA where it is outright banned and/or 7-OH and MGM-15 are such as the recent move in Florida’s kratom laws pertaining 7-OH.

Ok so every state is different, many states are regulating 7-OH and Kratom itself at this point, but only 12 states (afaik) it is a scheduled substance. The other states simply make it illegal to manufacture/sell/distribute not possession.

It's kind of messy and confusing but full bans seem to be enacted in:
Alabama, Arkansas, Connecticut (wow Ive been spelling Conneticut wrong in my head my whole life apparently), Florida, Indiana, Kansas, Kentucky, Louisiana, Mississippi, Tennessee, Vermont, and Wisconsin. These are places you could end up in jail or even prison for merely possessing 7-OH...

Ohio (I believe a full ban is coming, even for powder kratom but I don't think its active), Colorado, California, Arizona, Texas, Oregon, all prohibit sale/manufacture but not possession.

Washington, Illinois, Montana, Minnesota, Iowa, North Carolina, South Carolina, Georgia, Hawaii, it seems currently unregulated regarding possession and I think manufacture???
There's a lot of other states I didn't type in specifically.

People have been given prison sentences for simple kratom in i know at least Alabama. There's currently a woman looking at life in prison over 250g of leaf powder. I'd never visit that state regardless of this law personally.
I'm not a lawyer, but I can tell you the US is a patchwork of laws regarding 7-OH, so you HAVE to do your own research with each state.

The law is slow though, MGM-15, (which we make from 7-OH), is still legal in many places for the moment. The pseudoindoxyl also seems like it's hardly been touched. But I would really be careful about bringing any kratomalogue into any of the states that have downright banned it.

I generally agree with others... if you're opiate naive... unless you really want to experience morphine, why go straight to harder stuff.
Wouldn't it be tragic if someone from outside US, came here and crossed wrong state border with a kilo of powder and ended up getting charged with drug trafficking charges?
It blows my mind that someone looking at life in prison for 250g which for most people... is a month or 3 of supply. When I take kratom powder, my consumption is usually around 5g-10g a day.
They literally charge you the same as having 250g of heroin in some states.

Why would anyone even come to the US right now is beyond me. My own psuedogirlfriend from UK won't even visit, even if I paid her ticket. I totally get it.

 

[Syntherize]

Ok so every state is different, many states are regulating 7-OH and Kratom itself at this point, but only 12 states (afaik) it is a scheduled substance. The other states simply make it illegal to manufacture/sell/distribute not possession.

It's kind of messy and confusing but full bans seem to be enacted in:
Alabama, Arkansas, Connecticut (wow Ive been spelling Conneticut wrong in my head my whole life apparently), Florida, Indiana, Kansas, Kentucky, Louisiana, Mississippi, Tennessee, Vermont, and Wisconsin. These are places you could end up in jail or even prison for merely possessing 7-OH...

Ohio (I believe a full ban is coming, even for powder kratom but I don't think its active), Colorado, California, Arizona, Texas, Oregon, all prohibit sale/manufacture but not possession.

Washington, Illinois, Montana, Minnesota, Iowa, North Carolina, South Carolina, Georgia, Hawaii, it seems currently unregulated regarding possession and I think manufacture???
There's a lot of other states I didn't type in specifically.

People have been given prison sentences for simple kratom in i know at least Alabama. There's currently a woman looking at life in prison over 250g of leaf powder. I'd never visit that state regardless of this law personally.
I'm not a lawyer, but I can tell you the US is a patchwork of laws regarding 7-OH, so you HAVE to do your own research with each state.

The law is slow though, MGM-15, (which we make from 7-OH), is still legal in many places for the moment. The pseudoindoxyl also seems like it's hardly been touched. But I would really be careful about bringing any kratomalogue into any of the states that have downright banned it.

I generally agree with others... if you're opiate naive... unless you really experience morphine, why go straight to harder stuff.
Wouldn't it be tragic if someone from outside US, came here and crossed wrong state border with a kilo of powder and ended up getting charged with drug trafficking charges?
It blows my mind that someone looking at life in prison for 250g which for most people... is a month or 3 of supply. When I take kratom powder, my consumption is usually around 5g-10g a day.
They literally charge you the same as having 250g of heroin in some states.

Why would anyone even come to the US right now is beyond me. My own psuedogirlfriend from UK won't even visit, even if I paid her ticket. I totally get it.

I think that woman who got caught in Alabama with the kratom powder is free now finally. She supposedly had other prior drug charges for meth tho, but yeah screw Alabama and I never want to go there at all! If you watch the videos on YT of the arresting officers making a public statement about her arrest you can watch them say kratom is sold by the gram like fentanyl! WTF?!? These idiots have no clue what they are talking about about and that woman got the kratom at a vape shop along the border, she made a wrong turn, and got pulled over in Alabama which is one of the primary “prison states” in the USA—-they basically PROFIT off of incarcerating people over any little thing since they have no other economy there. Screw Alabama…

 

[PtahTek]

off topic but they also sell postage for letters by the gram

 

[helpingout]

heres my advice on the subject and i think you should consider my perspective above all of the others posted above for the simple reason that i am currently exactly where you are going to be.

ive been taking 7oh for about five weeks. todays the 26th. in fact, i just took my last dose so be sure to wish me luck. id love to walk away from this with no painful pronounced withdrawal and no difficulties whatsoever but i highly doubt that that will be my experience based on two kick attempts. one about three weeks prior, and one about last week. even three weeks of sustained daily use was enough to give me a profound withdrawal. let me start there.

three weeks of daily 7oh use. i was using about forty mgs about two or three times a day. the thing about 7oh is that it wears off fast and it diminishes in profundity relatively rapidly. meaning that the same dose taken three times in one day, will produce almost no noticable effect on that third dose. it seems to reset a little overnight but give it three days in a row and you just start really wanting to increase that dose. and when you do increase its relatively rewarding. you get the magic back.

i dont know how i ended up at forty milligrams. i know the smoke shop sold 40mg tablets for about 8 bucks each and i purchased those for the cost savings. anyways, three weeks of probably four times daily 20mg doses and i wanted off. i was a bit tapped financially and i was tired of the experience. the first night was no big deal. i had taken enough late enough in the day that i was able to sleep. but the next day at mid day. i noticed that i felt reasonably weird. off somehow. and that night was just a bit hellacious. tossing. turning. flailing my arms. kicking my legs. classic opioid withdrawal. nonsleep at all. the next day god smiled upon me and i got a check in the mail. i cashed it immediately using paypal and ingo bank and it was gone. the money didnt hit my account until about five pm. but my neifhbor had asked me to help him clear scotch brush at one pm, and so sick as a dog, i went out there and started clearing scotch brush and applying herbicide. well time went on and on and on and maybe it was the hot sun or the blackberry thorns that were scraping my skin and putting holes in me, i think pain ameliorates opioid withdrawal, i was able to get through the work and even take a nice three hour nap, much welcomed after the disappointment of the check getting lost, i wake up and the money had finally hit my account. but i felt better. so take that for what it is. three weeks of use, 20mg doses, and i had kicked for a solid two days, but vigorous physical exercise and a good solid pain treatment had afforded me sleep. i still felt kind of empty and made of air at the point i walked into the smokeshop but when i took my dose and that familiar warnth hit me i was so relieved and slept even deeper that night. so i was back on the train with about a two day break and a failure to stop using.

but now my dose had increased. i was taking a solid forty mgs per dose and struggling to keep up financially when i kinda had a god send. i found a place that sold Six hundred mg for twenty four dollars. roughly five times the amount of product for about the same price. from here my daily disage incrwased to a peak of 90mg per dose four times per day. at one point stound weej four i ran out of money and couldnt cover any more. i had to take an evening dose with no bed time dose and i never ended up falling asleep. from here i had pronounced physical withdrawal symptoms. brutal restless legs. loose bowels. i must have shit five or so times. i made it to five am the next morning and i was legit starting to feel alot better. but i managed to fund my account with enough to buy a pack and just wanting to work my workday without feeling the effects of withdrawal i caved and bought a pack.

which brings us to today. i just took my last 30mg dose. i have spent the whole week dropping from 90mg to the current 30. i would have liked to continue tapering but a very unique situation happened. i got injured at work and that injury allows me to have five days off in a row. im not a stupid man and i know the hand of the almighty when it brushes my life. i know that a skilled butcher isnt determined by the sharpness of their knife but by the knowledge of where they make their cut.

im fully expecting a sleepless night. im fully expecting restless legs, loss of bowel stability, possible hot and cold flashes, that slight delirium that accompanies withdrawal, teary eyes, sniffling dripping nose, and all the other little gems of kicking opiates like that lighter than air feeling that makes you feel like a space traveler in your own body.

i pray that i will learn from the hardship of this experience.
i pray that i will not go out and buy more opiates when the money hits my account on monday.
i pray that i will make the right choice and stay clean from here to the end of my days based on just the knowledge of how bad this could be.
i pray that being willing to face this experience is enough for the many faced god to spare me the complete ego death that opiate withdrawal can produce.

but maybe i need this more than anything i have ever needed in my life. maybe this experience will be the cement that binds me to my own recovery and delivers me to providence and prosperity.

the point for my communication to you being, absolutely expect a brutal and pronounced withdrawal after using for five weeks.

i know i am.

 

[AlwaysHasBeen]

Ok so every state is different, many states are regulating 7-OH and Kratom itself at this point, but only 12 states (afaik) it is a scheduled substance. The other states simply make it illegal to manufacture/sell/distribute not possession.

It's kind of messy and confusing but full bans seem to be enacted in:
Alabama, Arkansas, Connecticut (wow Ive been spelling Conneticut wrong in my head my whole life apparently), Florida, Indiana, Kansas, Kentucky, Louisiana, Mississippi, Tennessee, Vermont, and Wisconsin. These are places you could end up in jail or even prison for merely possessing 7-OH...

Ohio (I believe a full ban is coming, even for powder kratom but I don't think its active), Colorado, California, Arizona, Texas, Oregon, all prohibit sale/manufacture but not possession.

Washington, Illinois, Montana, Minnesota, Iowa, North Carolina, South Carolina, Georgia, Hawaii, it seems currently unregulated regarding possession and I think manufacture???
There's a lot of other states I didn't type in specifically.

People have been given prison sentences for simple kratom in i know at least Alabama. There's currently a woman looking at life in prison over 250g of leaf powder. I'd never visit that state regardless of this law personally.
I'm not a lawyer, but I can tell you the US is a patchwork of laws regarding 7-OH, so you HAVE to do your own research with each state.

The law is slow though, MGM-15, (which we make from 7-OH), is still legal in many places for the moment. The pseudoindoxyl also seems like it's hardly been touched. But I would really be careful about bringing any kratomalogue into any of the states that have downright banned it.

I generally agree with others... if you're opiate naive... unless you really want to experience morphine, why go straight to harder stuff.
Wouldn't it be tragic if someone from outside US, came here and crossed wrong state border with a kilo of powder and ended up getting charged with drug trafficking charges?
It blows my mind that someone looking at life in prison for 250g which for most people... is a month or 3 of supply. When I take kratom powder, my consumption is usually around 5g-10g a day.
They literally charge you the same as having 250g of heroin in some states.

Why would anyone even come to the US right now is beyond me. My own psuedogirlfriend from UK won't even visit, even if I paid her ticket. I totally get it.

SO you gonna flood the country with illegals and drugs if your party wins the Presidency? Because that is what you are saying you fucking dope.

 

[drewbocop]

Well this thread went off the rails quick. OP: the tolerance to the positive effects of 7oh come rapidly, and the half-life is very short, causing people to re-dose frequently and end up in a pickle. I think you should just buy a little bit when you want it, and leave it at that. Don't be set on being on it around the clock for 5 weeks. It wouldn't be that terrible, but it's a pretty stupid idea. Just don't fall in love.

Your mindset is kind of naive, and that's how people end up with opioid addictions.

 

[Didgital]

SO you gonna flood the country with illegals and drugs if your party wins the Presidency? Because that is what you are saying you fucking dope.

You must be unhinged because I never said ANY of that.
Not my fault you became a drug addict.. Nor the cartels.
YOU were the one who made the choice to use highly addictive opioids and you call me the dope?


Literally told the OP to not do the 7-OH, and was explaining the current laws in different states regarding kratom and the different kratomalogues out there....

Seek therapy, education, or both.

Lol at the illegals and presidency comment though that made me laugh.
Thanks for that. I needed it this morning.

 

[helpingout]

so i took four mg loperamide last night. licked out my little 7oh pillbox. ran the sharp corners of my pill blister over my skin to help with the restless legs snd made it through to today. its 300 and im still pretty tucking miserable. my body is very very cold but i feel extremely hot. all my hairs are on end. i think i have the conviction to make it past the money influx. i feel like dog shit tho. sneezing. weeping. emotional. im not shying away from this but i wont pretend that the temptation isnt there. im fucking miserable.

traveling likr this. taking five days to recover before i travel. or five days after. the timing. fuck all that. dont fo it