Didgital
Bluelight Crew
Ive never ever done any self injection, but thats probably the best way to go..
Anyone ever boof met salts??? Should work....
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Tryptamines The Big & Dandy MET Thread
- Thread starter ingo_2001
- Start date
Anyone ever boof met salts??? Should work....
Didgital
Bluelight Crew
It is very warm and rushy in the body. Glad n2o help w visual aspect.
I tried so hard to have a dmt esque breakthru w it, i gave up.
I still love MET and i wish it were easier to make. The disubstituted tryptamines are not as simple as one would wish
CavernsoftheMind
Bluelighter
- Joined
- Nov 28, 2024
- Messages
- 262
Tried MET fumarate last night for the second time.
We were already quite high on dissos (3-MeO-PCE + MXiPr) & wanted some more clear headedness upswing.
So we filled 30mg in an oil pipe, I heated it carefully, just to vaporize it.
It took some effort, but I was able to get some mild effects that way.
Heating it more than a few secs yielded a white smoke, which was pretty harsh, but managable. That smoke was more effective than the vapor.
I really need to basify some of it for the next time vaping it.
Then we snorted two 10-13mg lines, which worked well for me.
Burned like chili, was okay & stronger than the inhaling.
I really like the headspace it gives me.
Combining it with N2O is fantastic.
Euphoric spiritual vibrating energy through my body.
It really dominated the high dose dissociation.
We were able to talk clearly & think coherently.
I have a lot more to tell you, will update this.
We were already quite high on dissos (3-MeO-PCE + MXiPr) & wanted some more clear headedness upswing.
So we filled 30mg in an oil pipe, I heated it carefully, just to vaporize it.
It took some effort, but I was able to get some mild effects that way.
Heating it more than a few secs yielded a white smoke, which was pretty harsh, but managable. That smoke was more effective than the vapor.
I really need to basify some of it for the next time vaping it.
Then we snorted two 10-13mg lines, which worked well for me.
Burned like chili, was okay & stronger than the inhaling.
I really like the headspace it gives me.
Combining it with N2O is fantastic.
Euphoric spiritual vibrating energy through my body.
It really dominated the high dose dissociation.
We were able to talk clearly & think coherently.
I have a lot more to tell you, will update this.
Last edited:
jeff889911
Greenlighter
- Joined
- Jun 17, 2026
- Messages
- 1
i really want to make met changa adding it to damaina and then adding the damaina to my normal changa or just use the damaina with met. can someone please share a method to turn met into liquid freebase so that i can dissolve it in ipa with damaina? i read about a method about adding equal amount sodium carbonate, a candle and mixing but how do i know that the conversion from fumrate to freebase has taken place? i would appreciate it very much if someone who has had sucess with met change could reply to this and share
Didgital
Bluelight Crew
Take your MET salt. Dissolve in water. Slowly bring the pH up to 12 or so using Sodium Hydroxide in H2O. stick in fridge for an hour. filter out the (hopefully) chunky freebase through a coffee filter. crush, dry, dissolve in isopropyl.
You will know that conversion has taken place when the clear solution turns milky and stays milky after stirring. I add base until I don't see any more white flashing.
I don't know what MET looks like as a fb, some tryptamines are rather oily though and don't always want to turn solid. If that happens you just dissolve the oil right out of the coffee filter. Weigh the coffee filter first.
red22
Bluelighter
- Joined
- Nov 23, 2009
- Messages
- 2,236
MET Tolerance: What the Evidence Suggests
Based on these anecdotal reports and general pharmacological principles, here's a synthesis of what's going on with MET (N-methyl-N-ethyltryptamine) and tolerance:
The Anecdotal Pattern is Consistent
All five posts you've quoted point the same direction: MET appears to share DMT's low-tolerance profile. Specific claims include:
• "I didn't notice much" tolerance even after redosing same-day (boywonder, 2006)
• Ability to redose "again, and again, and again" without significant tolerance buildup (Dondante, 2006)
• Explicit framing that "simple short acting tryp's don't really form tolerance like normal long duration ones" (Help?!?!, 2013)
• Direct claim that MET has "much less considerable tolerance affliction than other tryptamines" (Help?!?!, 2017)
Why This Makes Pharmacological Sense
The likely mechanism tying these together is receptor kinetics tied to duration of action, not just chemical similarity to DMT:
1. Rapid dissociation from 5-HT2A: DMT and MET are both fast-onset, short-duration tryptamines. The leading hypothesis for acute tolerance (tachyphylaxis) to classical psychedelics involves 5-HT2A receptor internalization/desensitization, which requires sustained receptor occupancy. Drugs like LSD (which binds very tightly and has long duration) show pronounced acute tolerance; DMT, which clears quickly, doesn't give receptors time to desensitize significantly before the drug is gone.
2. MET's pharmacokinetics mirror DMT's: Since MET is also smoked/vaped and metabolized quickly (similar duration profile to DMT, as boywonder noted: "pretty much identical to DMT in duration"), it likely doesn't maintain receptor occupancy long enough to trigger the same desensitization cascade that slower-acting tryptamines (like psilocin from oral psilocybin, or LSD) do.
Bottom Line
The limited evidence (anecdotal, n=5 forum posts, not controlled studies) suggests MET's short duration and rapid clearance likely confer it the same "tolerance-resistant" property as DMT, probably for the same underlying pharmacokinetic reason (insufficient receptor dwell-time to trigger desensitization) rather than because of unique structural features of MET itself. This hasn't been formally studied in animals/humans the way DMT has (per your citations 27-29), so it remains an inference from user reports rather than an established pharmacological fact.
Claude Sonnet via arena.ai
*"it is difficult to produce tolerance to DMT in animals and humans,[11] [27–29]"
Ayahuasca: pharmacology, safety, and therapeutic effects. dos Santos R.G., Hallak J. E.C. 2025. CNS Spectrums, 30, 1:e2. 10.1017/S109285292400213X
The pharmacology of Ayahuasca
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11 Gillin, JC, Kaplan, J, Stillman, R, et al. The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine. Am J Psychiatry. 1976;133:203–208.
27 Cole, JM, Pieper, WA. The effects of N,N-dimethyltryptamine on operant behavior in squirrel monkeys. Psychopharmacologia. 1973;29:107–112.
28 Gillin, JC, Cannon, E, Magyar, R, et al. Failure of N,N-dimethyltryptamine to evoke tolerance in cats. Biol Psychiatry. 1973;7:213–220.
29 Kovacic, B, Domino, EF. Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat. J Pharmacol Exp Ther. 1976;197:495–502.
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Didgital
Bluelight Crew
I can personally attest that one can reenter MET space over and over. Such an excellent compound though I found it's low potency rather frustrating.
Has anyone here besides my self tried the 5-Fluoro cousin to make a comparison?
It's been so long since I had regular MET, but I found them mainly similar, with the 5F being a bit more stimulating somehow. Regular MET was soooooo relaxing Zenful. 5F was not as relaxing.
Has anyone here besides my self tried the 5-Fluoro cousin to make a comparison?
It's been so long since I had regular MET, but I found them mainly similar, with the 5F being a bit more stimulating somehow. Regular MET was soooooo relaxing Zenful. 5F was not as relaxing.
Didgital
Bluelight Crew
i should have, but i never tried MET orally.