Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

[Zopiclone bandit]

when I researched it via AI (so take with a pinch of salt), the conclusion was you reach a breakeven point on positive GABA effect after 1-2 week

My God!!!!!!

I said to another EADD member who somehow ended up with 4X 300mg Indian Pregab as an "extra gift" to take 600mg in one go on an empty belly, give it 60 mins & see how you feel, it can take upto 90 mins to even BEGIN to feel them so don't take more.
I told this person as they have never had Pregab if they liked it to wait 2-3 days before they did the other 600mg, I think my advice is a little out of target.

Thanks for that btw @placebonaut I am really starting to take to your tone & ways on BL to say the least.

 

[placebonaut]

I said to another EADD member who somehow ended up with 4X 300mg Indian Pregab as an "extra gift" to take 600mg in one go on an empty belly, give it 60 mins & see how you feel, it can take upto 90 mins to even BEGIN to feel them so don't take more.
I told this person as they have never had Pregab if they liked it to wait 2-3 days before they did the other 600mg, I think my advice is a little out of target.

I'd say with no tolerance 300mg is plenty.

There's kinda 4 tiers in my mind with pregab
1. 100mg-300mg - anxiolytic relaxing
2. 300mg - as above but also stimulating and lots of focus
3. 600mg - as above but very motivational, hyper focus and concentration, loads of energy
4. 900mg - visuals (almost ketamine like), very intense, bit jittery

for each level oral ROA draws out more of the lower tier while snorting draws out the higher tiers.

they potentiate the fuck outta benzo's, great combo, also plenty of weed!

Thanks for that btw @placebonaut I am really starting to take to your tone & ways on BL to say the least.

high praise, thanks. I'm a bit of a twat at times but I mean well

 

[Zopiclone bandit]

I'd say with no tolerance 300mg is plenty.

My first ever go with them I did 600mg, I have found myself 300mg isn't quite enough.
I know you have to give the brain a holiday from them so when I go on a Pregab session I want to get as fucked up as possible.

There's kinda 4 tiers in my mind with pregab
1. 100mg-300mg - anxiolytic relaxing
2. 300mg - as above but also stimulating and lots of focus
3. 600mg - as above but very motivational, hyper focus and concentration, loads of energy
4. 900mg - visuals (almost ketamine like), very intense, bit jittery

IMHO & Experience..........
100-300mg - I'd not even go there, it would seem a waste imho

600mg - Very bendy, like you said & you are 100% right "visuals (almost ketamine like) & my ex said to me "Lyrica has the same visual effect as MXE" as that's what they are called in Norway. For me it's like what I am viewing is a second behind the audio, it's a slight lag in it. I feel "removed" from normal life / feeling it's like I am behind" in any words I speak or if I dare to try to walk I take 3 steps to the left then the right & with the blessing of "God" I may be able to step forward in a straight line. Give it 4 hours into eating them I am "fucking moshed" & no good to do anything aparet from eat 500 grams of raw cheese.

800mg - Just fucking moshed, pissed myself in bed, woke up still feeling it well into the afternoon, I fell over a small dog on the way to get some milk in the morning. It's way too much for me to even function at the most basic level.

Nobody warned me about the hunger & the things you decide are worth eating when very high on Pregab, I have made HP Brown Sauce sandwichs before when I've been "fackin' moshed" on those damn things.

 

[placebonaut]

bloody strange, I don't feel hungry on them, usually don't eat at all!

I wonder if I'm even stranger that I thought?!

if you like the high dose and visual, try it with a bit a ketamine - ideally S-ISO, lots of fun, but reduce your ket dosage, take bumps until you reach your desired place.

 

[Zopiclone bandit]

bloody strange, I don't feel hungry on them, usually don't eat at all!

I get SO HUNGRY on them it's like the kinda hunger you get after a good MDPV smoking session.

if you like the high dose and visual, try it with a bit a ketamine - ideally S-ISO

I have no idea what S-ISO means sadly.
I have no access to Ketamine sadly, I don't know anyone who sells it on the street as my daily drug diet is 100% based around Smack as I have to have Opiates or I go into withdrawl very quickly.

My experience with those type of things is as listed.
Ketamine for years but only after Hard Techno Raves.
MXE for several years, both E.U. legal when it very first came on sale & also plenty of post-ban E.U. (Spain based vendor)
4-Meo-PCP was my #1 Disso, I did so much of that stuff I kinda "burned" my brain out with it & I got a huge tolerance with it. I had my most bizarre trip ever off that stuff, it was equal to a good dose of smoked Salvia. I ended up in a room with what I call "The Robot Geisha of hyperspace" who I had a long chat with & was warned if I ever ended up in their dimension WITHOUT asking them first I would be kept there, it shook me up but was the most bizarre & extreme trip I ever had & was 100% equal to any weird Spirit beings you may find on Salvia.

 

[placebonaut]

I get SO HUNGRY on them it's like the kinda hunger you get after a good MDPV smoking session.

wonder if it's only me?! does everyone else get the pregab munchies?

I have no idea what S-ISO means sadly.

S-ISO (S-Isomer) gives the K-hole & visuals, R-ISO is better for anxiety etc (I find it impossible to hole on it when snorting it), racemic is usually a 50:50 blend of the 2.

powdered epiphany, if it didn't fuck your bladder up I'd be doing loads of it, so very versatile

I have no access to Ketamine sadly, I don't know anyone who sells it on the street as my daily drug diet is 100% based around Smack as I have to have Opiates or I go into withdrawl very quickly.

sourcing it ain't hard.

know where you're at with smack from your other threads, I can only image.

There's some research coming out about ket therapy for opiate withdrawal - no idea if it works though

My experience with those type of things is as listed.
Ketamine for years but only after Hard Techno Raves.

Low dose while out is fun, but I prefer a high dose in bed, I'd be in a right tangle if I holed in a club! too old for that shit

 

[Zopiclone bandit]

There's some research coming out about ket therapy for opiate withdrawal - no idea if it works though

MXE was amazing for Heroin withdrawl & PAWS (Post Acute Withdrawl Syndrome)

I prefer a high dose in bed

100% the same, I would always put on the first Portishead album, cut a fucking stupid line & snort it all up then turn off the lights, put an eye mask on & crash back onto the bed.

 

[placebonaut]

I would always put on the first Portishead album

Their live album is in my top 10 of all time

 

[Zopiclone bandit]

Their live album is in my top 10 of all time

Live in NYC was shown in full on Sky Arts a few weeks ago.
It may still be up on the website, you heard of The Highway Men by any chance?

 

[placebonaut]

Live in NYC was shown in full on Sky Arts a few weeks ago.
It may still be up on the website, you heard of The Highway Men by any chance?

yeah heard of them, I quite like super groups in general but prefer these guys solo, especially Cash, give me some Folsom!

hmm I wonder if there's a super group thread, will have a search and make one if not

 

[Zopiclone bandit]

especially Cash, give me some Folsom!

LOLOLOL



A old time Ranch hand I know from East Texas who used to ride Bulls used to play this track over & over when he had to go ride out on a 200 acre ranch & round up the animals in a thunder storm & all that amazing East Texas weather I've heard about.

 

[20YearsInTheCan]

How on earth does one go about reducing their tolerance? I didn't have any for 2 whole weeks and took 600mg which barely did anything. I have been abusing it quite hard ill admit, but back in the day when I used to take this stuff I could take crazy doses with some regularity and it would always hit so long as i waited 2 or 3 days. Stupidly because I'm chasing the high I did 2100 the day after the 600 and again, the effects were very muted. I only started doing them again a month ago and I've already ruined them for myself!

 

[Bleaney]

How on earth does one go about reducing their tolerance? I didn't have any for 2 whole weeks and took 600mg which barely did anything. I have been abusing it quite hard ill admit, but back in the day when I used to take this stuff I could take crazy doses with some regularity and it would always hit so long as i waited 2 or 3 days. Stupidly because I'm chasing the high I did 2100 the day after the 600 and again, the effects were very muted. I only started doing them again a month ago and I've already ruined them for myself!

In general the only way is abstinence multiplied by time, and the time period required is going to depend on a lot of things.

If / when you do manage to abstain long enough, try to keep the days of using as far apart as possible.

I'm sure you know all of this, and I know it's much easier said than done, but there is simply no other way, as a general rule, for all substances, including pregabalin, AFAIK.

 

[placebonaut]

can't remember where I posted this before but I was taking 300mg of pregab once per week for about a year an took a 1 month break because I was noticing tolerance building up.

the month break didn't give me a full reset to baseline, I'd guess I need 400-450mg to get the same effect now that 300mg did for me when I 1st started using it.

I'm gonna just have to bite the bullet and do another break, maybe longer this time coupled with reducing other GABA shit

How on earth does one go about reducing their tolerance? I didn't have any for 2 whole weeks and took 600mg which barely did anything. I have been abusing it quite hard ill admit, but back in the day when I used to take this stuff I could take crazy doses with some regularity and it would always hit so long as i waited 2 or 3 days. Stupidly because I'm chasing the high I did 2100 the day after the 600 and again, the effects were very muted. I only started doing them again a month ago and I've already ruined them for myself!

Chasing this high is gonna be a problem, 300 day 1 = 600 day 2 = 1200 day 3 etc. Don't use it on consecutive days is the simple answer, take longer breaks between usage.

As Bleany said "abstinence multiplied by time".

what else if anything are you using? my tolerance seems to have some linkage to the other GABA shit I take.

the amounts and frequency you're hinting at make me think that you might need a taper if you're going to reduce your usage though...

 

[BadBoy377]

I fucking love cheese @Zopiclone bandit and could easy eat half a kilo high or sober. Albeit different types at once but half a kilo nae problem

 

[Snövit-Rödvit]

the tolerance on these things is insane, I did another 600mg last night & I only felt at best 70% of the effect I was after.
How long do most people take as a break from these things so they get the full effect?

when I researched it via AI (so take with a pinch of salt), the conclusion was you reach a breakeven point on positive GABA effect after 1-2 weeks, a month break for me gave noticeable improvements but I'm planning on giving them a 2 month break at some point. Going to cut out all GABA I think at the same time, then when I start taking them again I'm going to be much more narrow in what I take.

Mixing and matching different GABA is creating compounded problems for me with partial cross tolerance, from what I've read better to stick to 1 thing that way your GABA systems isn't constantly trying to adapt. Suspect part of the reason when 1 month wasn't enough for me

How on earth does one go about reducing their tolerance? I didn't have any for 2 whole weeks and took 600mg which barely did anything. I have been abusing it quite hard ill admit, but back in the day when I used to take this stuff I could take crazy doses with some regularity and it would always hit so long as i waited 2 or 3 days. Stupidly because I'm chasing the high I did 2100 the day after the 600 and again, the effects were very muted. I only started doing them again a month ago and I've already ruined them for myself!

I don’t know your dosage pattern but I do large binges every month. 5-10g total over 8-11 days and being off it for 60days return some of the effect but not even near that euphoria I’m after.

For acute resensitization after acute down regulation it takes 14-21 days to return to baseline.
For continuous downregulation homeostasis is achieved after 60-90days.
For heavy, frequent binges like mine neuro adaptation sets in, and for complete structural homeostasis it can take a year or longer or even be permanent.

90 days should be enough for complete vgcc turnover. In the past it had landed me very close to what I’m looking for, but the next day I’m back to the same tolerance like I just had a 10g binge.

 

[placebonaut]

I fucking love cheese @Zopiclone bandit and could easy eat half a kilo high or sober. Albeit different types at once but half a kilo nae problem

half a hilo in 1 sitting, bloody impressive effort!

 

[placebonaut]

I don’t know your dosage pattern but I do large binges every month. 5-10g total over 8-11 days and being off it for 60days return some of the effect but not even near that euphoria I’m after.

I find tolerance ramps very very very quickly with consecutive days use

For acute resensitization after acute down regulation it takes 14-21 days to return to baseline.
For continuous downregulation homeostasis is achieved after 60-90days.
For heavy, frequent binges like mine neuro adaptation sets in, and for complete structural homeostasis it can take a year or longer or even be permanent.

90 days should be enough for complete vgcc turnover.

some interesting numbers there, is this is a general statement or is there research on this specifically linked to Pregabalin?

 

[BadBoy377]

half a hilo in 1 sitting, bloody impressive effort!

It's as much a curse as it is a skill.

Also transferrable to steak.

The gout really isn't worth it though.

 

[Wormwood44]

Excellent thread so far. I have already commented on my thoughts/experiences with Lyrica. I take it once or twice a week so as not to waste all of my Lyrica; I work from home doing coding - taking 400mg once around noon keeps me feeling good AND I can still function and concentrate on this Lyrica dose, even though I get distracted a bit. Everyone is different in how a particular dosage affects them. This week I am trying 600mg on a day off. Which brings up an interesting topic that has been shared a little bit before: is re-dosing during a Lyrica experience effective at all?