Novel Opioids

[4DQSAR]

i see, i assumed flourination alot simpler but i was completely wrong there thats good to know. Thats good to know thank you for explaining

Well, I know someone who was spashed with HCl or HF as whichever muppet was meting out reagents had the nasty habit of just putting things in unmarked (plastic) bottles. So they got rushed to hospital to be told 'well, IF it's HCl, we can manage the burns. If it's HF, we have to chop off you legs NOW'. He risked it for a biscuit and was lucky as it was just HCl.

Other worthy notables was someone who was under the impression that they had inhaled HCN. So again to the hosptial who pointed out that if it WAS a fatal dose, the person would already be dead. How cheering!

This stuff can be so unforgiving, especially if people ASSUME things. It's monkey-thinking to assume because you were OK 99 times in a row, somehow that altered the percieved risk so that 100th time would be just fine.

That's why I drilled into people to read the MSDS every single time - because those things can change. We only discovered that dimethyl mercury goes straight through latex gloves when professor Karen Wetterhahn let a drop fall onto her gloved hand. She did everything right - followed the protocols to the letter. She died, it shocked us all because she WAS the best. How she died is even worse but if nothing else, we don't use 199Hg any more. Like 'magic methyl' which did what it said on the tin, but a Dutch team spilt some and methylated all hell out of their lungs. Now just synthesizing the stuff is a sacking offence. I've seen them come and go. Like the hypervalent iodine compounds. Used in early mitragynine research but MIA as if you drop it, YOU go MIA as well.

Working in a properly resourced laboratory is still a dangerous space so home-built crank labs are totally insane. Who knows how many die? Because I highly doubt survivors would announce their operation. From time to time we hear of it. Like the Mexican cook who was using H2S to make HI, got confused and tried to salt his product with the H2S. Found dead in his garden. H2S causes paralysis of the lungs amongst other things such as numbing the sense of smell so you do not actually smell the fatal dose. You get a whiff and think it's gone away when in fact the levels are rising.

Hence us not discussing the fine detail of syntheses. Hardly HR if people think 'I can do that' without realizing that the synthesis as written is just the bare-bones. It ASSUMES you are a trained chemist.

When the 30 years has passed, I will tell you about disassebling a lab at high speed. QUITE impressive when seen on national TV. Not so much at the time and in the place.

 

[Featherfall]

Well, I know someone who was spashed with HCl or HF as whichever muppet was meting out reagents had the nasty habit of just putting things in unmarked (plastic) bottles. So they got rushed to hospital to be told 'well, IF it's HCl, we can manage the burns. If it's HF, we have to chop off you legs NOW'. He risked it for a biscuit and was lucky as it was just HCl.

Other worthy notables was someone who was under the impression that they had inhaled HCN. So again to the hosptial who pointed out that if it WAS a fatal dose, the person would already be dead. How cheering!

This stuff can be so unforgiving, especially if people ASSUME things. It's monkey-thinking to assume because you were OK 99 times in a row, somehow that altered the percieved risk so that 100th time would be just fine.

That's why I drilled into people to read the MSDS every single time - because those things can change. We only discovered that dimethyl mercury goes straight through latex gloves when professor Karen Wetterhahn let a drop fall onto her gloved hand. She did everything right - followed the protocols to the letter. She died, it shocked us all because she WAS the best. How she died is even worse but if nothing else, we don't use 199Hg any more. Like 'magic methyl' which did what it said on the tin, but a Dutch team spilt some and methylated all hell out of their lungs. Now just synthesizing the stuff is a sacking offence. I've seen them come and go. Like the hypervalent iodine compounds. Used in early mitragynine research but MIA as if you drop it, YOU go MIA as well.

Working in a properly resourced laboratory is still a dangerous space so home-built crank labs are totally insane. Who knows how many die? Because I highly doubt survivors would announce their operation. From time to time we hear of it. Like the Mexican cook who was using H2S to make HI, got confused and tried to salt his product with the H2S. Found dead in his garden. H2S causes paralysis of the lungs amongst other things such as numbing the sense of smell so you do not actually smell the fatal dose. You get a whiff and think it's gone away when in fact the levels are rising.

Hence us not discussing the fine detail of syntheses. Hardly HR if people think 'I can do that' without realizing that the synthesis as written is just the bare-bones. It ASSUMES you are a trained chemist.

When the 30 years has passed, I will tell you about disassebling a lab at high speed. QUITE impressive when seen on national TV. Not so much at the time and in the place.

i'll be sure to hit you up in 2050, thanks for elaborating on this, you sometimes tend to forget about how dangerous chemistry can sometimes be, especially with this type of stuff. Fucking scary