Lysergamides LSI, Ancient LSD, Secret of the Eleusis Kykeon and Vedic SOMA

[tregar]

Tripped on 44 HBWR seeds converted to LSI last night, absolutely incredible!!! Had the time of my life: zero side effects, zero vasoconstriction, zero nausea. Felt just like 180ug of LSD but much more euphoric, colorful, and musical. Hours and hours of colored open eyed magical visuals and way beyond 4k closed eye colored visions. Euphoria, music enhancement, and visuals just like that of 550mg high dose mescaline.

Felt identical to 550mg of the Heavenly mescaline. Scraped up 200mg of LSA extract from the pyrex dish with 2 razor blades, then stirred it for 10 minutes with 10mg tartaric acid powder ($8 on line) and 3g or 1 pack of the nitrogen sealed Aojiru barley grass. My absolute favortie psychedelic, have taken 11 times now, averaging once a month for the past 10 months now. Took only 45 minutes, the 3 easy steps are illustrated in the book. Most of the time is spent waiting between the two 10-minute stirring steps and the 30 minute evaporation step. Super easy.

How this works:
Ask google in AI, response is:

Yes, Tartaric acid can interact with and bind to the NH group of LSA indole, particularly through hydrogen bonding [4.4, 4.6].

• Interaction Mechanism: Tartaric acid acts as a hydrogen-bond donor (via its hydroxyl and carboxylic acid groups), while the indole NH acts as a hydrogen-bond donor itself, or more commonly, the interaction is mediated through the acidic, polar, and hydrogen-bonding environment created by the tartaric acid, often forming stable complexes [4.4, 4.6].

Chemical formula for tartaric acid is C4 H6 06, and according to AI it can indeed bond to the NH amide of LSA in acidic environments with stirring. Notice acetaldehyde has the formula of C2 H5 O which binds to the NH amide of LSA to form the psychedelic LSH or Lysergic Acid Hydroxyethylamide (see the molecular picture of LSH I posted in green color here):

TARTARIC ACID has many more carbons and hydrogens and oxygen molecules than acetaldehyde, perhaps explaining the incredible potency of my Kykeon and Vedic SOMA 2oz brew, this raises many questions and is actively being investigated.

 

[tregar]

Beautifully illustrated 12 page paper on ancient LSI (Lysergic Acid Isovaleraldamide) being published on Graham Hancock's official website in a few days from 4.3.26: https://grahamhancock.com/stahlm1/

3 super easy steps from HBWR seeds to LSI: takes only 50 minutes, most of time spent waiting between the 10 minute stirring step, the 30 minute evaporation step, and the last 10 minute stirring step.

44 seeds converted just as powerful as 180ug LSD but even beyond LSD, much more euphoric, colorful, and music enhancing than LSD, effects identical to 550mg of high dose Heavenly mescaline.

LSI interview going up on April 20, 2026: https://mckenna.academy/mka-podcast/

 

[red22]

This is what Claude responded with after I showed it the only in-depth study on LAH:

Separation of four isomers of lysergic acid α-hydroxyethylamide by liquid chromatography and their spectroscopic identification. Flieger, M., Sedmera, P., Vokoun, J., R̆ic̄icovā, A., R̆ehác̆ek, Z. 1982. Journal of Chromatography A, 236(2), 441–452. 10.1016/S0021-9673(00)84895-5
https://www.bluelight.org/community/posts/16404795

───────────────────────
The Flieger paper describes hemiacetal chemistry:

R-NH-CO-CH(OH)R' ⇌ R-NH-CO-CHO + R'H (reversible)

Stahl is claiming direct amide substitution:

LSA (R-CO-NH₂) + aldehyde → R-CO-NH-CH₂-R' (stable new amide)

These are completely different reactions with different:

• Mechanisms

• Energy barriers

• Equilibrium positions

• Stability profiles

The "Considerable Instability" Problem

The paper explicitly states these compounds are unstable and exist in equilibrium mixtures. Direct quotes:

"considerable instability of the compounds under study"
"isomerization products...found to be formed on heating"
"mutual transformation of II to IV was observed during a 15-h ¹³C NMR measurement"

This means:

• You can't just "make LSI and drink it"

• You'd have a constantly shifting mixture

• Storage would be impossible

• Dosing would be unpredictable

Why Stahl's Extrapolation Fails Chemically​

Acetaldehyde vs. Isovaleraldehyde

Property	Acetaldehyde	Isovaleraldehyde
Formula	CH₃CHO	(CH₃)₂CH-CH₂-CHO
MW	44	86
Steric bulk	Minimal	Significant (branched)
Reactivity	Very high	Lower
Water solubility	Miscible	Limited

The size and branching of isovaleraldehyde would dramatically alter:

• Reaction kinetics

• Equilibrium position

• Steric accessibility to the amide

The Fermentation Context

The Flieger paper studied Claviceps paspali fermentation, where:

• LAH is produced biosynthetically

• Acetaldehyde is a metabolic byproduct

• Enzymes may catalyze reactions

• pH, temperature, and media are controlled

Stahl's "kitchen chemistry" involves:

• LSA extracted from seeds (not LAH)

• Barley powder with trace aldehydes (μg/kg levels)

• No enzymatic catalysis
───────────────────────

"Albert Hofmann, Gordon Wasson, and Carl Ruck famously speculated in The Road to Eleusis (1978) that the psychedelic Kykeon drink of the Eleusinian Mysteries may have contained ergot-contaminated barley — a hypothesis later bolstered by ergot remains found in 1997 on a human jawbone at a Demeter temple excavation in Spain." From Claude's summary of The Mystery in the Rye by Frank Petersen

 

[tregar]

You have not tried my Sacred Brew, whereas I have tried 11 times now, once a month for the past 11 months, works beautifully, incredibly powerful, taking again today as a matter of fact. Please start your own thread, and stop trying to crash mine for the past 5 pages, you would not know as you have never tried it. Please just stop trolling me, get your own thread.

Tripped on 44 HBWR seeds converted to LSI last night, absolutely incredible!!! Had the time of my life: zero side effects, zero vasoconstriction, zero nausea. Felt just like 180ug of LSD but much more euphoric, colorful, and musical. Hours and hours of colored open eyed magical visuals and way beyond 4k closed eye colored visions. Euphoria, music enhancement, and visuals just like that of 550mg high dose mescaline.

Felt identical to 550mg of the Heavenly mescaline. Scraped up 200mg of LSA extract from the pyrex dish with 2 razor blades, then stirred it for 10 minutes with 10mg tartaric acid powder ($8 on line) and 3g or 1 pack of the nitrogen sealed Aojiru barley grass. My absolute favortie psychedelic, have taken 11 times now, averaging once a month for the past 10 months now. Took only 45 minutes, the 3 easy steps are illustrated in the book. Most of the time is spent waiting between the two 10-minute stirring steps and the 30 minute evaporation step. Super easy.

How this works:
Ask google in AI, response is:

Yes, Tartaric acid can interact with and bind to the NH group of LSA indole, particularly through hydrogen bonding [4.4, 4.6].

• Interaction Mechanism: Tartaric acid acts as a hydrogen-bond donor (via its hydroxyl and carboxylic acid groups), while the indole NH acts as a hydrogen-bond donor itself, or more commonly, the interaction is mediated through the acidic, polar, and hydrogen-bonding environment created by the tartaric acid, often forming stable complexes [4.4, 4.6].

Chemical formula for tartaric acid is C4 H6 06, and according to AI it can indeed bond to the NH amide of LSA in acidic environments with stirring. Notice acetaldehyde has the formula of C2 H5 O which binds to the NH amide of LSA to form the psychedelic LSH or Lysergic Acid Hydroxyethylamide (see the molecular picture of LSH I posted in green color here):

TARTARIC ACID has many more carbons and hydrogens and oxygen molecules than acetaldehyde, perhaps explaining the incredible potency of my Kykeon and Vedic SOMA 2oz brew, this raises many questions and is actively being investigated.

Beautifully illustrated 12 page paper on ancient LSI (Lysergic Acid Isovaleraldamide) being published on Graham Hancock's official website in a few days from 4.3.26: https://grahamhancock.com/stahlm1/

3 super easy steps from HBWR seeds to LSI: takes only 50 minutes, most of time spent waiting between the 10 minute stirring step, the 30 minute evaporation step, and the last 10 minute stirring step.

44 seeds converted just as powerful as 180ug LSD but even beyond LSD, much more euphoric, colorful, and music enhancing than LSD, effects identical to 550mg of high dose Heavenly mescaline.

LSI interview going up on April 20, 2026: https://mckenna.academy/mka-podcast/

 

[Skorpio]

You have not tried my Sacred Brew, whereas I have tried 11 times now, once a month for the past 11 months, works beautifully, incredibly powerful, taking again today as a matter of fact. Please start your own thread, and stop trying to crash mine for the past 5 pages, you did the same thing at the shroomery, you would not know as you have never tried it. Please just stop trolling me, get your own thread. I know who you are and I will call you out if you keep trolling me.

Tripped on 44 HBWR seeds converted to LSI last night, absolutely incredible!!! Had the time of my life: zero side effects, zero vasoconstriction, zero nausea. Felt just like 180ug of LSD but much more euphoric, colorful, and musical. Hours and hours of colored open eyed magical visuals and way beyond 4k closed eye colored visions. Euphoria, music enhancement, and visuals just like that of 550mg high dose mescaline.

Felt identical to 550mg of the Heavenly mescaline. Scraped up 200mg of LSA extract from the pyrex dish with 2 razor blades, then stirred it for 10 minutes with 10mg tartaric acid powder ($8 on line) and 3g or 1 pack of the nitrogen sealed Aojiru barley grass. My absolute favortie psychedelic, have taken 11 times now, averaging once a month for the past 10 months now. Took only 45 minutes, the 3 easy steps are illustrated in the book. Most of the time is spent waiting between the two 10-minute stirring steps and the 30 minute evaporation step. Super easy.

How this works:
Ask google in AI, response is:

Chemical formula for tartaric acid is C4 H6 06, and according to AI it can indeed bond to the NH amide of LSA in acidic environments with stirring. Notice acetaldehyde has the formula of C2 H5 O which binds to the NH amide of LSA to form the psychedelic LSH or Lysergic Acid Hydroxyethylamide (see the molecular picture of LSH I posted in green color here):

TARTARIC ACID has many more carbons and hydrogens and oxygen molecules than acetaldehyde, perhaps explaining the incredible potency of my Kykeon and Vedic SOMA 2oz brew, this raises many questions and is actively being investigated.

Beautifully illustrated 12 page paper on ancient LSI (Lysergic Acid Isovaleraldamide) being published on Graham Hancock's official website in a few days from 4.3.26: https://grahamhancock.com/stahlm1/

3 super easy steps from HBWR seeds to LSI: takes only 50 minutes, most of time spent waiting between the 10 minute stirring step, the 30 minute evaporation step, and the last 10 minute stirring step.

44 seeds converted just as powerful as 180ug LSD but even beyond LSD, much more euphoric, colorful, and music enhancing than LSD, effects identical to 550mg of high dose Heavenly mescaline.

LSI interview going up on April 20, 2026: https://mckenna.academy/mka-podcast/

Hydrogen bonding is the association of two molecules by means of an h-bond donor and acceptor. These are not covalent bonds and are generally more important for the behavior of water and proteins than chemical bonding.

You aren’t going to have two molecules stay together in your body due to hydrogen bonding because your body is chock full of water and proteins which all want to hydrogen bond with the LSA as much as the tartaric acid does.

Hydrogen bonding is pulling at straws far beyond adduct formation.

 

[tregar]

I've tried this x 12 times now, once a month now for a year, last night was absolutely incredible, converted 45 HBWR seeds to the Sacred brew, experienced zero side effects, zero anxiety, just as powerful as 180ug LSD or 550mg mescaline.

For 8 strong hours, she felt identical to 550mg high dose mescaline, bold out of this world neon colors all night, infinite music enhancement, infinite euphoria, hours and hours of magical colored open eye visuals and colored closed eye visions.

Swimming in euphoria and visions all night long, She is an ultimate psychedelic, my absolute favorite, made in 50 minutes, 3 very easy steps.

Learn more: Illustrated 12 page paper on ancient LSI on Graham Hancock's official website: https://grahamhancock.com/stahlm1/

LSI interview going up on April 20, 2026: https://mckenna.academy/mka-podcast/

 

[tregar]

Brand new April 18, 2026 You tube:

Pic of genuine HBWR seeds & tartaric acid used: https://mycotopia.net/topic/112442-lsi-ancient-lsd-secret-of-the-eleusis-kykeon/page-3

 

[tregar]

#58, LSI interview with Dr. Mckenna now up: https://mckenna.academy/mka-podcast/

LSI illustrated paper: www.grahamhancock.com scroll down to 1st article

 

[red22]

Cracking the 2,000-Year-Old Kykeon Mystery | Dennis McKenna on LSA & Soma  @mckenna.academy  2026.04.20  h‍ttps://m.youtube.com/watch?v=NqrvJdsKzYM



37:10 "I never realized that THH was a psychedelic in its own right."

"In one person tetrahydroharmine was similarly hallucinogenic when given in three times the dose of harmaline."  β-carbolines, psychoactive compounds in the mammalian body. Airaksinen MM, Kari I. 1981. Part II: Effects. Med Biol, 59(4):190-21  Studies on the hallucinogenic and other CNS effects

The Big & Dandy Syrian Rue & Harmala MAOI Alkaloids Thread

 

[donotdothis]

"To determine if an ethanol extract of 40 Argyreia nervosa (HBWR) seeds contains a "high dose" of ergometrine, we have to look at the cumulative alkaloid weight compared to standard medical applications.

Based on the average concentration of 10 μg to 50 μg of ergometrine per seed, an extract of 40 seeds would contain:
Low estimate: 400 μg (0.4 mg)
High estimate: 2,000 μg (2.0 mg)

Comparison to Medical Standards​

In a clinical setting, ergometrine (ergonovine) is a potent pharmaceutical used primarily to control postpartum hemorrhage due to its ability to cause powerful uterine contractions and systemic vasoconstriction.
Standard Medical Dose: A typical single dose is 0.2 mg (200 μg).
The 40-Seed Extract: At the high end (2.0 mg), this extract would contain 10 times the standard medical dose of ergometrine.

By pharmaceutical standards, this is considered an extremely high—and potentially toxic—dose of this specific alkaloid.

Could repeated high doses of ergometrine cause vasoconstriction and lead to brain damage?

Repeated high doses of ergometrine (also known as ergonovine) can cause severe vasoconstriction that may lead to permanent brain damage. This occurs primarily through a mechanism of prolonged or intense cerebral vasospasm.

Mechanism of Vasoconstriction​

Ergometrine is an ergot alkaloid that acts as a potent agonist at alpha-adrenergic, dopaminergic, and serotonergic (5−HT2) receptors. Its primary medical use is to induce uterine contractions to prevent postpartum hemorrhage, but its effects are not localized. When levels in the bloodstream are high or sustained, it triggers the smooth muscles in blood vessel walls to contract throughout the body, including the cerebral arteries.

Progression to Brain Damage​

The risk of brain damage from ergometrine typically follows a specific pathological progression:

• Reversible Cerebral Vasoconstriction Syndrome (RCVS): High doses of ergot derivatives are a known trigger for RCVS. This condition is characterized by the sudden constriction of cerebral arteries, often presenting as "thunderclap" headaches.
• Cerebral Ischemia: If the vasoconstriction is severe enough, it restricts blood flow to specific regions of the brain. This lack of oxygen (ischemia) can lead to localized tissue death.
• Stroke: Prolonged vasospasm can result in an ischemic stroke. Conversely, the rapid fluctuation in vascular tone and pressure can also lead to hemorrhagic stroke (bleeding in the brain) or Posterior Reversible Encephalopathy Syndrome (PRES).
• Convulsive Ergotism: Historically, chronic or acute poisoning with ergot alkaloids led to "convulsive ergotism," where neurological symptoms like seizures, mania, and cognitive impairment occurred due to the drug's effects on the central nervous system and its impact on cerebral vasculature.

Risk Factors​

The likelihood of neurological damage increases significantly under the following conditions:
Dosage: Repeated high doses overwhelm the body's ability to metabolize the drug, leading to sustained vascular tension.
Hypersensitivity: Some individuals have a higher vascular sensitivity to ergot alkaloids.
Drug Interactions: Taking ergometrine alongside CYP3A4 inhibitors (like certain antibiotics or antivirals) can prevent its breakdown, leading to toxic levels in the blood even at standard doses.

While the "reversible" in RCVS suggests the constriction eventually eases, the infarctions (cell death) that occur while the vessels are constricted are permanent, resulting in lasting neurological deficits or brain damage."

 

[red22]

───────────────────────
1 April 1976

12.20 h: 2.0 mg ergonovine hydrogenmaleinate, containing 1.5 mg ergonovine base, ingested in a glass of water.

13.00 h: slight nausea, same effect as I have experienced always in my LSD or psilocybin experiments. Tired, need to lie down. With eyes closed colored figures.

13.30 h: the trees in the nearby forest seem to live, their branches moving in a threatening way.

14.30 h: strong desire to dream, unable to do systematic work, with eyes closed or open afflicted by mollusk-like forms and feelings.

16.00 h: motives and colors have become clearer, but bearing still some hidden dangers.

17.00 h: after a short sleep I awoke by a kind of inner explosion of all the senses.

18.00 h: an unexpected visit forced me to become active, but during the whole evening I lived more in an inner than in the outer world.

22.00 h: all effects worn off, normal feeling.

This was an experiment performed without attention to “set and setting” but it proves that ergonovine possesses a psychotropic, mood-changing, slightly hallucinogenic activity when taken in the same amount as [an] effective dose of lysergic acid amide, the main constituent of ololiuhqui. Its potency is about one twentieth of the potency of LSD and about five times that of psilocybin.
───────────────────────
Albert Hofmann. The Road to Eleusis: Unveiling the Secret of the Mysteries. 1978, 2008. R. G. Wasson, Albert Hofmann, Carl A. P. Ruck, Peter Webster. North Atlantic Books: Berkeley, CA. 9781556437526. Chapter 2. A Challenging Question and My Answer, page 41

 

[donotdothis]

why would anyone add a potent vasoconstrictor to Ololiuqui?

 

[tregar]

I've taken this to 45 HBWR seeds converted to LSI, absolutely no side effects, no vasoconstriction experienced whatsoever. Felt identical in effects to 550mg Heavenly mescaline, absolutely no side effects, it's worked 100% each of the 12 times I've drank the Sacred brew over a 1 year period (taken once a month).

 

[donotdothis]

That's great and I hope it is being synthesized. Please keep us updated.

 

[donotdothis]

"This extraction method (pH 4, tartaric acid, ethanol) is a classic example of optimizing for alkaloid recovery rather than chemical transformation or purification. While often cited in amateur literature as a way to "clean" the experience, the underlying chemistry and pharmacology do not support the elimination of vasoconstriction.

Using tartaric acid to reach a pH 4 environment ensures that the alkaloids, including the potent vasoconstrictor ergometrine, are almost entirely protonated into their salt form (e.g., ergometrine tartrate). In this ionized state, ergometrine is highly soluble in polar solvents like ethanol. Instead of removing the vasoconstrictor, this specific pH level ensures that nearly the entire payload of ergometrine is successfully pulled from the seed pulp and concentrated into the final liquid.

A common theory suggests that aldehydes (like those in peppermint oil) react with the alkaloids to form a "cleaner" adduct called LSI. However, ergometrine is a secondary amide. Chemically, it is sterically hindered and much more stable than the primary amide LSA. Even if a reaction occurred with other alkaloids, the ergometrine remains largely unchanged and active in the acidic ethanol solution.

The idea that adding peppermint oil provides enough vasodilators to "counter" the vasoconstriction fails the test of quantitative pharmacology. Ergometrine is effective at the microgram (μg) scale. 10 seeds provide roughly 400–500 μg, which is double a standard medical dose. Compounds in peppermint oil (like menthol or isovaleraldehyde) are relatively weak and act on different pathways.

To physiologically "cancel out" 0.5 mg of a high-affinity alkaloid, you would need tens or hundreds of milligrams of these terpenes. The few drops of oil used in standard extractions provide a negligible amount of vasodilatory force compared to the powerful, receptor-saturated squeeze of the ergoline alkaloids."

 

[Allylbenzene]

"This extraction method (pH 4, tartaric acid, ethanol) is a classic example of optimizing for alkaloid recovery rather than chemical transformation

Btw - whatever you used to write your last post is confused as it has made several errors, and misinterpretations.

 

[peaches88]

I really enjoyed the podcast with Dennis McKenna @tregar, congratulations! I got a chance to listen to it in full today. I liked that Dennis took time to get into the THH topic too - that part really reignited my interest in THH.

Has the publication of the podcast stirred up any exciting conversations or developments on your end?

 

[tregar]

Thanks Peaches for viewing and for the kind words. I sent Dr. Dennis Mckenna and Graham Hancock a thank you message, as the podcasts have helped dramatically to get the message out. I tried to contact the producers of the Joe Rogan show (as this is right down his alley) but he and his producers only answer emails from famous people, so no luck there. All my life I've dreamed of having a field of bridgesii cactus, and now with this discovery, the dream has come true as each time I've prepared a brew from 45 seeds, she has felt exactly or identical to 550mg of mescaline, so goal achieved. As stated at the end of the podcast, the chemist at the Shulgin Farm labs in California and Dr. Nichols will be taking this further, as I've had emails from these scientists.

 

[red22]

I sent Dr. Dennis Mckenna and Graham Hancock a thank you message, as the podcasts have helped dramatically to get the message out. I tried to contact the producers of the Joe Rogan show (as this is right down his alley) but he and his producers only answer emails from famous people, so no luck there.

So ask Dennis or Graham H. to contact Joe Rogan for you. Obviously.

 

[donotdothis]

"Even when divided twelve times, the concentration of alkaloids remains high. Ergine and ergometrine are potent in very small quantities. At this fractional level, you are still left with approximately 0.18 mg of ergometrine, which is nearly identical to a standard 0.2 mg clinical dose used specifically to cause intense vascular constriction. This primary vasoconstrictor is then reinforced by the remaining ergine, which continue to tighten blood vessels and increase muscle tension. The physical load does not disappear with the dilution."