Kratom to 7OH potency not making sense to me.

[Mushoku_Sensei]

I'm on my 3rd day of withdrawal off approx 24mg/day, which is not a whole lot, of 7-oh and it is pretty unpleasant, fucking with my head hard. I took a week off work to do it, work would not be possible right now. I hope I'm good by next Monday, withdrawal is usually not this bad.

I noticed the head fuck as well. Worse than most other opis I tried

 

[thurston]

I noticed the head fuck as well. Worse than most other opis I tried

I'm doing good today, I'm at about 85% normal now which I can handle, I could even work today if I had too. Yesterday was pretty fucking rough until the evening, but I woke up really good today. I almost broke down twice over tye last few days but I didn't and I'm glad. The depression was fucking for real during those days. It was hard to keep the bad thoughts at bay.

 

[Mushoku_Sensei]

I'm doing good today, I'm at about 85% normal now which I can handle, I could even work today if I had too. Yesterday was pretty fucking rough until the evening, but I woke up really good today. I almost broke down twice over tye last few days but I didn't and I'm glad. The depression was fucking for real during those days. It was hard to keep the bad thoughts at bay.

That's good to hear.. For me it's been the first day though I'm "simply" back to Kratom powder... Gone is the balance I used to have ...

 

[plumsmooth]

Not familiar with 7oh, but Kratom contains a whole bunch of various alkaloids that are making it a way more complex drug than any single extract could ever be. Afaik even science is currently only speculating that mitragynin/7oh are responsible for the main effect, so it makes sense to me that the experience is not equal by any means... In addition to questionable content as said before.

Good Point makes me think some people may even associated their Subjective/objective effects with alkaloids other then the M and maybe the Seratonin agonisism?

 

[plumsmooth]

It makes me laugh when idiots describe cannabis as a gateway drug lol
The drug to open your eyes to all other drugs is alcohol
It lowers your inhibition to the point your up for anything
If your that way inclined that is

I genuinely believe the true and one and only original gateway drug is....




WHITE SUGAR

 

[SigmaDrugCollector]

Tolerance builds insanely fast with 7-oh in my experience. If you take that same dose for 2 days in a row , on the third day you will definitely need more to achieve the same effect. If you dose the same it will leave you hanging & not last like it did previously. Kratom is more consistent in dosing over long periods. Plus it's hard to know the true milligrams from batch to batch.

SigmaDrugCollector

 

[thurston]

How it is ?

I wasn't too bad that next day. I wouldn't have wanted to work but I could have. By the next Monday when I had to go back to work I was 90% good. I haven't taken any since. I Take kratom/7-oh for chronic pain so I've been through this many times. I usually quit a couple of times a year to reset tolerance. I try to go as long as possible but a flare up always gets me.

I get hyperhydrosis from opiates so I usually try to time my breaks with hot weather.

I also needed to quit to see if the simponi infusions were starting to work. They unfortunately don't seem to be.

 

[cnnka]

I wasn't too bad that next day. I wouldn't have wanted to work but I could have. By the next Monday when I had to go back to work I was 90% good. I haven't taken any since. I Take kratom/7-oh for chronic pain so I've been through this many times. I usually quit a couple of times a year to reset tolerance. I try to go as long as possible but a flare up always gets me.

I get hyperhydrosis from opiates so I usually try to time my breaks with hot weather.

I also needed to quit to see if the simponi infusions were starting to work. They unfortunately don't seem to be.

So it’s actually light for you also I take daily also at 12.5-15mg that’s the whole dosage I spread it over 3-4 small dosages each dose last around 2 hours. Of course tolerance has increased over time but it still works just not as intense as it was at first , first times with 5mg I was almost nodding. Nowdays I just get a little high little comfortable I take some days off like every week or every 2 weeks usually anywhere from 1-3 days off and honestly I haven’t noticed any WD’s.
I’ve been addicted to regular kratom before and with kratom I definitely did have the WD’s with 7OH I just don’t have them or are very light I can’t notice them clearly.

 

[Mushoku_Sensei]

So it’s actually light for you also I take daily also at 12.5-15mg that’s the whole dosage I spread it over 3-4 small dosages each dose last around 2 hours. Of course tolerance has increased over time but it still works just not as intense as it was at first , first times with 5mg I was almost nodding. Nowdays I just get a little high little comfortable I take some days off like every week or every 2 weeks usually anywhere from 1-3 days off and honestly I haven’t noticed any WD’s.
I’ve been addicted to regular kratom before and with kratom I definitely did have the WD’s with 7OH I just don’t have them or are very light I can’t notice them clearly.

Wow.. You're quite lucky then so far. I went up to 40 -60 mg per day and absolutely couldn't catch the WD with Kratom for a week almost. Given I've had my fair share of kindling before and am still stuck with Kratom by now...

 

[helpingout]

I wonder if 7oh has a similar process in the liver to heroin in that if heroin is consumed orally it converts to an eight chain morphine ring which is essentially just morphine that can cross the blood brain barrier more effectively than morphine can do so without being altered by the liver.

So does kratom’s mitragynine undergo some kind of alteration in the liver that makes it very pleasant because opioid naive kratom is a pretty amazing drug. It feels clean and good like soaring euphoria with very little sedation at all. Even reds.

Whereas 7oh seems to be somewhat sedating. I could catch like four or five solid nods off some 7oh doses. Never the hours of nodding like morphine or other full agonists but definitely like four or five solid nods. Where kratom was never very sedating to me no matter how much I took.

Seems to be something there but I don’t have the data to draw any conclusions.

 

[cnnka]

I wonder if 7oh has a similar process in the liver to heroin in that if heroin is consumed orally it converts to an eight chain morphine ring which is essentially just morphine that can cross the blood brain barrier more effectively than morphine can do so without being altered by the liver.

So does kratom’s mitragynine undergo some kind of alteration in the liver that makes it very pleasant because opioid naive kratom is a pretty amazing drug. It feels clean and good like soaring euphoria with very little sedation at all. Even reds.

Whereas 7oh seems to be somewhat sedating. I could catch like four or five solid nods off some 7oh doses. Never the hours of nodding like morphine or other full agonists but definitely like four or five solid nods. Where kratom was never very sedating to me no matter how much I took.

Seems to be something there but I don’t have the data to draw any conclusions.

They both feel pretty neutral to me. However, like you said, 7OH definitely has an edge when it comes to sedative effects. I’ve actually caught nods on 7OH before. I can still take it and do chores or other stuff, but after a while I definitely just want to sit down and relax.

Kratom felt more stimulating overall, even the reds like you mentioned. I’ve never nodded on kratom, but I did have one of my most pleasurable highs ever from red kratom combined with some hash. Honestly one of the best nights for me. The weird part is I could never recreate that experience, it only happened once.

You might be onto something though, because kratom and its alkaloids seem really complicated. It makes sense that kratom itself feels more stimulating while pure 7OH feels more sedative. The experience also changes depending on the “colors,” probably because of the different alkaloid profiles.

What makes me skeptical about your theory though is that I’ve tried MIT isolate and it barely felt like anything at all. If I felt anything, it was slightly stimulating. When I added MIT to kratom, it actually seemed to make the experience more stimulating. Meanwhile pure 7OH feels much more sedative and opioid like.

Have you tried any of the other alkaloids like pseudonxyl or MGM-15?
Also, how would you compare 7OH to classical opiates? I’d really like to hear your thoughts on it overall, like its benefits and drawbacks. A full review would be really interesting to hear from you.

 

[Mushoku_Sensei]

I wonder if 7oh has a similar process in the liver to heroin in that if heroin is consumed orally it converts to an eight chain morphine ring which is essentially just morphine that can cross the blood brain barrier more effectively than morphine can do so without being altered by the liver.

So does kratom’s mitragynine undergo some kind of alteration in the liver that makes it very pleasant because opioid naive kratom is a pretty amazing drug. It feels clean and good like soaring euphoria with very little sedation at all. Even reds.

Whereas 7oh seems to be somewhat sedating. I could catch like four or five solid nods off some 7oh doses. Never the hours of nodding like morphine or other full agonists but definitely like four or five solid nods. Where kratom was never very sedating to me no matter how much I took.

Seems to be something there but I don’t have the data to draw any conclusions.

Good points really

 

[Mushoku_Sensei]

They both feel pretty neutral to me. However, like you said, 7OH definitely has an edge when it comes to sedative effects. I’ve actually caught nods on 7OH before. I can still take it and do chores or other stuff, but after a while I definitely just want to sit down and relax.

Kratom felt more stimulating overall, even the reds like you mentioned. I’ve never nodded on kratom, but I did have one of my most pleasurable highs ever from red kratom combined with some hash. Honestly one of the best nights for me. The weird part is I could never recreate that experience, it only happened once.

You might be onto something though, because kratom and its alkaloids seem really complicated. It makes sense that kratom itself feels more stimulating while pure 7OH feels more sedative. The experience also changes depending on the “colors,” probably because of the different alkaloid profiles.

What makes me skeptical about your theory though is that I’ve tried MIT isolate and it barely felt like anything at all. If I felt anything, it was slightly stimulating. When I added MIT to kratom, it actually seemed to make the experience more stimulating. Meanwhile pure 7OH feels much more sedative and opioid like.

Have you tried any of the other alkaloids like pseudonxyl or MGM-15?
Also, how would you compare 7OH to classical opiates? I’d really like to hear your thoughts on it overall, like its benefits and drawbacks. A full review would be really interesting to hear from you.

MIT alone had me nod exactly once in a combo with 300 mg Pregabalin - and I couldn't repeat it no matter how much I tried. There's a one time only effect to quite a few drugs for me including 7oh (where the first 5 mg felt better than anything I could get out of it later) and Pregabalin where it worked 2-3 times maybe just to never return. There must be some pretty long lasting changes induced in the brain that effectively stop that from happening again - at least euphoria-wise, while sedation can still be achieved.