Opioids Oxycodone hydrochloride

[Demize]

Hey I'm on 35mg Methadone for a long time. Have been shooting 2mg Dilaudid with a wheel filter and dont get much out of it. Slight rush, if I do 4mg I will always get a serotonin toxicity event. Very severe, why I can't figure out. But severe chills and posturing for about an hour. I now have Oxycodone hydrochloride 10mg which I will take orally due to best route of absorption. Question is dosage. How much to get high? I don't want to eat 80mgs and get in trouble so I thought best to ask?

 

[Ballu]

I don't believe anyone can really answer the question on how much you should take, as we all have different bodies and different tolerances. I think the best way to gage this is by starting with a small amount, feeling it out and if that amount doesn't do it for you, then take more.

Always remember, you can always take more if you don't take enough the first time.. but once you've taken too much, it's not much you can really do to reverse the amount you've taken(apart from narcan).

 

[Dextro .45]

Methadone has a high affinity for the mu-opioid receptor and 30-40mg is sufficient to reduce or totally eliminate the euphoric feeling from other abused opioids, Oxy, Dilaudid, Heroin, etc

That’s why Methadone is so successful in weaning off opioids and prevention of illicit abuse….cause after you WASTE $100 on OxyContin 80’s crush em up and bang em IV injection, and you feel NOTHING …..you’re like,fuck that …..last time for that.

I’m on Methadone 100-125mg daily……started on 30mg about 20 years ago after Dilaudid, Oxy-IR, H, etc…….worked up to 100-125 currently

Methadone blocks the euphoric rush from other opioids

Stop taking ur Methadone for a week and then inject that shit….youll feel it

Methadone is also a VERY euphoric opioid in its own right …..a full opioid agonist

 

[Jnowhere]

Methadone has a high affinity for the mu-opioid receptor and 30-40mg is sufficient to reduce or totally eliminate the euphoric feeling from other abused opioids, Oxy, Dilaudid, Heroin, etc

That’s why Methadone is so successful in weaning off opioids and prevention of illicit abuse….cause after you WASTE $100 on OxyContin 80’s crush em up and bang em IV injection, and you feel NOTHING …..you’re like,fuck that …..last time for that.

I’m on Methadone 100-125mg daily……started on 30mg about 20 years ago after Dilaudid, Oxy-IR, H, etc…….worked up to 100-125 currently

Methadone blocks the euphoric rush from other opioids

Stop taking ur Methadone for a week and then inject that shit….youll feel it

Methadone is also a VERY euphoric opioid in its own right …..a full opioid agonist

Methadone is Very euphoric in it's own right?

First time I ever heard or read that.

Oxy, has ~85% bioavailability, why shoot it?

 

[notsmokeymcpot42088]

^ Facts - shooting oxy is not great for many reasons. Morphine I would empathize with ...

100 - 125 mg methadone a day as you know it would cost you a damn arm and a leg to get a good high on pharm pills (Perhaps literally if you insist on IV'ing *rimshot*)

NOW THE REAL ISSUE -- said serotonin toxicity. I just said in another thread somewhere nothing scares me like serotonin syndrome and I did not know it could be gained through poly opiate abuse --- and wonder a bit....

 

[Demize]

^ Facts - shooting oxy is not great for many reasons. Morphine I would empathize with ...

100 - 125 mg methadone a day as you know it would cost you a damn arm and a leg to get a good high on pharm pills (Perhaps literally if you insist on IV'ing *rimshot*)

NOW THE REAL ISSUE -- said serotonin toxicity. I just said in another thread somewhere nothing scares me like serotonin syndrome and I did not know it could be gained through poly opiate abuse --- and wonder a bit....

Just to clarify I am on Setraline for a long time and oddly would shoot the 4mg water soluble Dilaudid when I was getting them and don't remember having this effect. However I am on Chemo Therapy so God only knows what effect those substances are having on me. But I thank you all for your replies. Yes it's scary, it's alot like cotton fever in its intensity and short duration. Very weird.

 

[Dextro .45]

Methadone is Very euphoric in it's own right?

First time I ever heard or read that.

Oxy, has ~85% bioavailability, why shoot it?

Never shot Oxy mainly actually…..just H and Hydromorphone

Oral Oxycodone is hands down my favourite opioid and the most euphoric, a non sedating, slightly stimulating opioid synthesized from theBaine …..not like morphine or Diacetylmorphine (Heroin)

Eukadol (Oxycodone) original German patient actually states the drugs profound euphoric narcotic effects and potent analgesic properties

Oxycodone & Ritalin (Methylphenidate) are the only 2 drugs to give me significant euphoric bliss …..the best oral speedball with alcohol and cigarettes

 

[Them Witches]

If your not dissolving Oxycodone HCl under your tongue your wasting it. Every time I suggest this to someone, they say "Yeah I can feel that." and forever dissolve under the tongue.

The bioavailability, BBB cross, and duratrion is better. It adds a sedation element. Technically it is "taken by mouth."

If you want to make it interesting, toss Clonidine under there at the same time.

No more Jedi secrets released for the day...

 

[Them Witches]

30-40mg is sufficient to reduce or totally eliminate the euphoric feeling from other abused opioids, Oxy, Dilaudid, Heroin, etc

I would say 60mg is the cut off point for me. This why I take Methadone 10mg every 6hrs between Oxycodone 30mg every 4hrs. It keeps the pain relief dropping below a certain level and physical dependence addressed.

 

[bkwixom]

Never shot Dilaudid or any pill...any advice on how? to turn pill into liquid

 

[4DQSAR]

Yeah. Oxycodone interacts not only with other medications (of many different classes) but also interacts with certain foods.

I was prescribed low dose amitriptyline to help with neuropathic pain (and it worked) but when, after just two decades of constant pain, a consultant finally prescribes Oxylan (generic Oxycontin) BUT told me to stop taking the amitriptyline as both modulate eatracellular monoamine levels i.e. have the potential to cause serotonin syndrome.

AS @Dextro .45 points out. 40% of Oxycontin is actually immediate release so I've even been told by a clinician that my 10mg 'rescue' Oxylans can be sucked on for 5 minutes and then swallowed. The only difference is that instead of peak-plasma levels taking 90-120 minutes, it's more like 20-30 minutes. I don't do that on a regular basis. But I freeze up i.e. the pain is so bad I can't take a single step.

I tell you, it's utterly humiliating to end up 200 yard from home and having to call for an ambulance. They were very nice about it but what if someone had a heart attack and my call ends up getting them killed due to the delay? That was twenty years ago and I still feel guilty about it.

 

[Dextro .45]

Yeah. Oxycodone interacts not only with other medications (of many different classes) but also interacts with certain foods.

I was prescribed low dose amitriptyline to help with neuropathic pain (and it worked) but when, after just two decades of constant pain, a consultant finally prescribes Oxylan (generic Oxycontin) BUT told me to stop taking the amitriptyline as both modulate eatracellular monoamine levels i.e. have the potential to cause serotonin syndrome.

AS @Dextro .45 points out. 40% of Oxycontin is actually immediate release so I've even been told by a clinician that my 10mg 'rescue' Oxylans can be sucked on for 5 minutes and then swallowed. The only difference is that instead of peak-plasma levels taking 90-120 minutes, it's more like 20-30 minutes. I don't do that on a regular basis. But I freeze up i.e. the pain is so bad I can't take a single step.

I tell you, it's utterly humiliating to end up 200 yard from home and having to call for an ambulance. They were very nice about it but what if someone had a heart attack and my call ends up getting them killed due to the delay? That was twenty years ago and I still feel guilty about it.

Well….just like any XR formulation…..you can pulverize the beads into fine powder, it’s now IR

BIPHENTIN 80mg XR beads (Methylphenidate) …..40% is IR remeaining 60% released 4-6 h later…..for bi phasic release, hence the name Biphentin

I pulverize my XR caspules so it’s IR Ritalin (Methylphenidate)…..essential in my oral cocktail

Methadone 100-125mg (160 tablets monthly)
Ritalin (Methylphenidate) 50-70mg IR
Avizafone (Pro-Diazepam) IM injection 80mg = Valium 40mg
Pregabalin 300mg
Ethanol & cigarettes

I’ve been on this daily for 20+ years so I’m extremely tolerant ……the dopaminergic stimulant is ABSOLUTELY essential. A staple. Period. Enhancing the analgesic properties of the opioid, reducing any sedation and improving cognitive functioning, increased vigilance, potent mood-boosting properties

Very euphoric & pleasurable…..but when ACTUALLY needed for chronic pain…..Fck, is like drinking water and eating……without it, I’d be barely alive . I’m 6’ male 240lbs tolerant to all substances so my doses are very manageable and low ish for ME ……a lethal dose for many others

Brompton Cocktail …..can’t be beaten even a proper Speedball


Pharmaceutical grade Diacetylmorphine (Heroin) and pure Cocaine HCL pharma grade……Amytal a proper barbiturate……..fuuuuuuuuuck, your melting into heavens warm blanket of security & comfort

1850 in Royal Brompton Hospital in England ….reserved for end of life suffering usually

An oral Brompton Cocktail is my daily drink…..seriously

 

[notsmokeymcpot42088]

Never shot Dilaudid or any pill...any advice on how? to turn pill into liqui

Well you do not want to inject dry powder. Somehow I feel like you are too far from actually achieving this for me telling you to be 'harm reduction' without a bit more context

You opiate dependant? What is your tolerance, how long you been using?

I ask as the first time I IV'd I had a bunch of dilaudid pills and literally walked about a block to the pharm and bought 100 rigs --- luckily I had bluelight or I woulda fucked up much more than I did. (Which does imply it did not go perfectly the first time)

You know how to register a vein right?

 

[notsmokeymcpot42088]

Methadone 100-125mg (160 tablets monthly)
Ritalin (Methylphenidate) 50-70mg IR
Avizafone (Pro-Diazepam) IM injection 80mg = Valium 40mg
Pregabalin 300mg
Ethanol & cigarettes

I’ve been on this daily for 20+ years so I’m extremely tolerant ……the dopaminergic stimulant is ABSOLUTELY essential. A staple. Period. Enhancing the analgesic properties of the opioid, reducing any sedation and improving cognitive functioning, increased vigilance, potent mood-boosting properties

I gotta call bullshit just because avizafone hasn't been around for 20 years --- 40mg valium and the rest check out.

 

[Dextro .45]

I gotta call bullshit just because avizafone hasn't been around for 20 years --- 40mg valium and the rest check out.

Yes…..Avizafone has been added to the lineup last year ….I’ve made maybe 15 orders over 1-2 years …..each 3 gram, a few were 3G X 3 - 9,000mg in a single order, made three of those

20 years ago it was

Methadone 100mg
Ritalin (Methylphenidate) 50-70 IR
Diazepam 10mg X 3-4
Alprazolam 1mg
Pregabalin 300mg
Ethanol

After an hour or two of drinks full C-Max achieved, maybe a few small thin lines of Yayo & Ketamine 50/50 splite before heading out with a fresh drink for a smoke.

I don’t bullshit brother…..”impressing” randoms online is not how I get my confidence. Even at the range, bragging to people my groupings are tighter blah blah……there’s only ONE person I continue to desire to impress brother….only person that counts.

Me

 

[notsmokeymcpot42088]

I didn't think so man -- I been reading your posts along time. I dont think anyone is ever impressed on this site anyways -- which is a good thing I suppose haha

I was wondering if pregabalin went 20 years back --- than I remembered I am old and yea it did.

That is a good lineup, personally the ritalin/pregabalin would mess it all up for me --- but those are both 'individual reactions' afaik/I am concerned

Congrats on having the income plugs and discipline to keep that up that long

(That brompton cocktail is pretty bomb! I just smoked the hash/pot, drank the ethanol as ya know....effort and not wanting to lose the solution or IV'ability)

 

[4DQSAR]

I gotta call bullshit just because avizafone hasn't been around for 20 years --- 40mg valium and the rest check out.

Well, technically it was granted a GB patent in 1978 BUT it's ONLY use was to treat people poisoned by a nerve agent. I'm almost certain it was only sold to the military well into the 21st century.

Came in solution in autoinjectors. Commonly known to medics as 'yellow tops'. After that came a series of pre-treatment medications and those turned out to be quite hazardous.

In fact, injectable benzodiazepines were limited to the military and in-patient settings until just a few years ago. I think the logic was that if injected, paradoxical agitation can be an issue.

 

[notsmokeymcpot42088]

I figured it was "A thing" for longer and was hoping for some kind of oddball story of such and how dude had access way before us......figured it wasn't bullshit based on poster history...

But calling bullshit gets a good story (Occasionally a true and good story) sometimes lol

 

[4DQSAR]

I've SEEN yellow tops but thankfully never had to use one. They were only issued if there was a real chance that there could be nerve agents as, well, squaddies get bored and sometimes can't sleep so before a patrol they were counted out, after they were counted back in. Military medicine is a bit rough and ready but that's the thing - your role is just do do the MARCH PAWS and get them to a proper clinician.

FYI morphine autoinjectors were called 'red tops'.

Keep it simple.

Lovely people but as we say about squaddies 'THE ARMY - all the crayons you can eat'.

 

[notsmokeymcpot42088]

red tops good to know -- if you dont mind me inquiring how many mg's a guy who gets shot and likely is dying get in one of them red tops?

Ive always kinda wondered that -- we goin 10mg (traditional) or like 100 in that situation