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Tryptamines Why is dmt considered the strongest psychedelic?

M

Mike Lamson

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Dec 7, 2025
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I have done it and have experienced some profound trips but I still would argue lsd is a lot more potent then dmt. 1mg of dmt is a very light mild trip, where as 1mg of lsd would have you travelling the Silk Road in its prime and for a lot longer then dmt would. Is dmt maybe considered the strongest because of its higher possibility of transformative experiences through its use? Or just the profoundness of a higher dose experience?
 
At a guess its just cos it's got a lot more publicity in the last 30 years. All the Terence Mckenna shite. I saw some right-winger just the other day on a podcast talking about "taking" DMT - obviously he'd never had DMT in his entire life - but he's droning on about "And then I saw the elves..."

Dunno - maybe they think it makes them macho and tough cos they've taken the "strongest" psychedelic and lived to tell the tale? Yeah - acid is a whole other depth of experience than smoking DMT.
 
If you’re talking intensity the clear winner is 5-MeO-DMT it’s almost indescribable. It’s so vivid for me it was being catapulted into a rendition of Disney on Ice lifting Minni-Mouse above my head while doing a pirouette, color, taste, smell, everything.

LSD is strong but that's more to do with dose managment.
 
Yeah but anything smoked is over in a flash - so its intense for a few seconds.
 
DMT comes in many forms, you have NN’DMT from plants, 5-MEO-DMT from the toad, 5-Bromo-DMT that even comes from sea sponges and even 4-ACO-DMT which is a synthetic derivative of Psilocin which is the psychedelic chemical converted by the body from psilocybin which is found in magic mushrooms and truffles. There is a lot of types of DMT out there and a lot of psychedelics for which one is the strongest I think that’s all individualistic due to drugs work for different people in different ways. Not sure if you’ve heard of the quote from Terence McKenna about taking 5 dried grams of psylocybe cubensis in the dark.
 
probably because of how famous, actually strong it is, and easily available it is compared to others, but it's definitely not the absolute strongest, and it all depends on dose anyway. Freebase is deffo kinda brutal but at the same time somewhat gentle? salvia is more unhinged and scary. 5-meo stories are fucked up as well.

I kind of miss DMT actually, i always came back from those small but intense trips with no background anxiety for a day or so but a part of me is still scared/reverent of it, and maybe that's for the best. At least for now. I'm enjoying my other smoother stuff more anyway.
 
Docta said:
If you’re talking intensity the clear winner is 5-MeO-DMT it’s almost indescribable. It’s so vivid for me it was being catapulted into a rendition of Disney on Ice lifting Minni-Mouse above my head while doing a pirouette, color, taste, smell, everything.

LSD is strong but that's more to do with dose managment.
Click to expand...

Really? For me 5-MeO-DMT felt as Shulgin described it i.e. 'like being sat on by an elephant'. I did have a gram of the stuff that I had instrumental data for so I knew what I had.

It's another case of YMMV.

Some find LSD stronger, some find DMT stronger, some find 5-MeO-DMT stronger and I'm sure some people will feel mescaline, psilocin or indeed something synthetic out of the Shulgin canon to be stronger.

I freely admit my response to 5-MeO-DMT made me pass on an offer to try 5-MeO-AMT. Even twenty five years ago it was known to have killed people and given my response to the parent, I decided I did not wish to take that risk.
 
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Sixx_Psychonaut said:
DMT comes in many forms, you have NN’DMT from plants, 5-MEO-DMT from the toad, 5-Bromo-DMT that even comes from sea sponges and even 4-ACO-DMT which is a synthetic derivative of Psilocin which is the psychedelic chemical converted by the body from psilocybin which is found in magic mushrooms and truffles. There is a lot of types of DMT out there and a lot of psychedelics for which one is the strongest I think that’s all individualistic due to drugs work for different people in different ways. Not sure if you’ve heard of the quote from Terence McKenna about taking 5 dried grams of psylocybe cubensis in the dark.
Click to expand...
That's not correct, common mistake but DMT only means N,N-DMT - all of those other compounds are distinct, and not forms of DMT.

The most common one that people mix up is 5-MeO-DMT - however 5-MeO-DMT is no more a kind of DMT than it is a kind of melatonin. Neither do we say 5-MeO-DMT is a form of melatonin.
 
Yeah strongest can go to a few different molecules. Salvia can be heavy. I think think they are described as strong because a person can lose his environment and can forget they took a drug. Where as other psychedelics you can go out and play in the world if you want. With the strong ones you stay put and go very inward.

Completely off topic but wasn't there mention of someone smoking melatonin with an effect? I am looking around here for that.
 
Docta said:
"gram" is that a typo?
Click to expand...

Sorry, I meant to say I had a gram in hand - of pure material which was quite tricky as you have to find the right solvent to remove imputies and I didn't know what solvent that would be (n-hexane as it turned out).

Yeah, deprotect melatonin and methylate. Salted, removed crud with n-hexane, based it out.

Interesting little bit of the practical, hated the product.
 
4DQSAR said:
Sorry, I meant to say I had a gram in hand - of pure material which was quite tricky as you have to find the right solvent to remove imputies and I didn't know what solvent that would be (n-hexane as it turned out).

Yeah, deprotect melatonin and methylate. Salted, removed crud with n-hexane, based it out.

Interesting little bit of the practical, hated the product.
Click to expand...
What was the product?
 
JackARoe said:
Yeah strongest can go to a few different molecules. Salvia can be heavy. I think think they are described as strong because a person can lose his environment and can forget they took a drug. Where as other psychedelics you can go out and play in the world if you want. With the strong ones you stay put and go very inward.

Completely off topic but wasn't there mention of someone smoking melatonin with an effect? I am looking around here for that.
Click to expand...
Any links on the smoking melatonin? I'm interested. Not in doing it. Just hearing more...
 
BadBoy377 said:
Any links on the smoking melatonin? I'm interested. Not in doing it. Just hearing more...
Click to expand...
I am on a deep search for it here. I’ll find something, the conversation was spoken about, but not to any great degree. I do like the notion though.
 
It was time to get more DMT but I goofed on the website (which had been changed radically)

I clicked DMT in the drop down for psychedelics and a page displayed for various carts, and I picked the one I thought I usually do and went through the motions of payment and obtained what I ordered 3 or 4 days later.

I put the cart on my battery and sucked for 5 seconds and BAM that was not expected. - complete time flange - followed by crushingly heavy trails and body sense frame stacks.

I had a few more one second pulls and they were very strong as well but not nearly as visual as I expected. Mostly I got sensory FRAME STACKING trails and compounding feelings.

The next day I thought I should figure out what happened.
I look at the cart and it says 5MeO-DMT not NN-DMT which I thought I ordered.
I checked the invoice and I actually had ordered 5MeO not NN
I then went to the website and saw that they do not even display any NN-DMT anymore unless you click SHOW ALL which is a hidden button.

so not only is it a different drug with half the same name, it is masquerading its way into the market, and every mention of DMT really should clarify by having the prefix to tell you what drug it is.

NN-DMT is a very pretty thing, it may be useful but I consider it just a fun or pleasure thing. groovy strong but very likeable.
5MeO-DMT is weird as fuck (I want to say it's like salvia divinorum but it is not exactly as nice - nor is it safe at all dosages - which salvia actually seems to be)

both xx-DMT drugs do raise blood pressure and are active at smaller amounts that people are usually advised - 5MeO-DMT is not that visual while NN-DMT is usually very visual in most cases. Salvia is more Visual in all cases but 5MeO remains a bit intriguing because of trails and time stacks, though I will purposefully try to never buy it again.
 
pupnik said:
It was time to get more DMT but I goofed on the website (which had been changed radically)

I clicked DMT in the drop down for psychedelics and a page displayed for various carts, and I picked the one I thought I usually do and went through the motions of payment and obtained what I ordered 3 or 4 days later.

I put the cart on my battery and sucked for 5 seconds and BAM that was not expected. - complete time flange - followed by crushingly heavy trails and body sense frame stacks.

I had a few more one second pulls and they were very strong as well but not nearly as visual as I expected. Mostly I got sensory FRAME STACKING trails and compounding feelings.

The next day I thought I should figure out what happened.
I look at the cart and it says 5MeO-DMT not NN-DMT which I thought I ordered.
I checked the invoice and I actually had ordered 5MeO not NN
I then went to the website and saw that they do not even display any NN-DMT anymore unless you click SHOW ALL which is a hidden button.

so not only is it a different drug with half the same name, it is masquerading its way into the market, and every mention of DMT really should clarify by having the prefix to tell you what drug it is.

NN-DMT is a very pretty thing, it may be useful but I consider it just a fun or pleasure thing. groovy strong but very likeable.
5MeO-DMT is weird as fuck (I want to say it's like salvia divinorum but it is not exactly as nice - nor is it safe at all dosages - which salvia actually seems to be)

both xx-DMT drugs do raise blood pressure and are active at smaller amounts that people are usually advised - 5MeO-DMT is not that visual while NN-DMT is usually very visual in most cases. Salvia is more Visual in all cases but 5MeO remains a bit intriguing because of trails and time stacks, though I will purposefully try to never buy it again.
Click to expand...
What is frame stacking?
 
BadBoy377 said:
Any links on the smoking melatonin? I'm interested. Not in doing it. Just hearing more...
Click to expand...

5-MeO-DMT.

I didn't like it one bit. I suspect I never consumed enough to 'break through' because the physical side-effects were so unpleasent. I felt poisoned, specifically the 'sat on by an elephant' feeling Shulgun described.

I knew what I had (instrumental analysis) and others liked it, just not me.
 
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Aye, fair enough cheers.

I suppose if I was in the middle of the jungle with a bunch of folk who it was their normal Saturday night gig before they go armadillo hunting then well... It would rude not to.

Otherwise I'll pass.
 
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