Opioids The Ultimate Opiate Potentiation Thread v2.0

[Endochemdonutholefingerin]

I mean a couple of different things when it comes to the title I just used.

Firstly, when it comes to potentiating opiates/heroin, if you plan to potentiate the drug, is it best to do it before and is in your system? I imagine it is but then that leads me to another question. Can you potentiate the drug when it's already in your system? I imagine the answer is either "yes, to a degree", "sort of" or "no". For instance, grapefruit juice is said to potentiate H. Could I smoke some H then drink some juice to potentiate the high or would that have no effect at all? I know common sense would lead you to drink the juice first and if I had any juice I would, but it's just in theory for the sake of the question.

How long after a dose of smoking H would I need to wait to be able to take the necessary things to potentiate my next dose properly/to a noticeable degree?

I could make this much more long winded than it is but I couldn't be bothered with a long thread this time so I'll leave the question there.

The main reason I ask this is that I usually smoke H before taking any potentiators as I'm not thinking. I'm mainly wondering if you can potentiate whilst you're smoking the drug or how long you should wait after smoking it to potentiate the next dose.

If anybody knows anything about this then please let me know, thanks!

Corydalis root powder works great. Gives it a nice face lift

 

[The Holy Quadruplty]

Diphenhydramine Chlorpheniramine and Xanax to potentiate Buprenorphine also weed.

 

[hakced]

I really don't get the effects of 30 mg oxy unless I snort with Adderall I usually do 20 mg or 40 mg of ritilin tho not working like it used to. If you use your oxy for energy like I do be careful if you don't have a steady source of ADHD meds because prolonged use will ruin oxy effect without. At least for me I have a very hi tolerance to oxy and had to find a way to get the feeling without taking 3 30's at a time. My wife distributes me my oxy as prescribed after years of watching me finish my script in a week. She takes them also and even ends up giving me some of hers. She has tremendous will power. So when this started it was hell and adding the Adderall really boosts the oxy.

 

[dethkids]

I'm going to merge your thread in with the Ultimate Opiate Potentiation Mega Thread v2.0. It'll have the information you need.

oh i almost forgot soma is great for it thank you love2party

Dude everyone is just missing the true power of soma w/ opiates. Its best to get clean with, knock u the f out sleep through all the hell. Amazing. Seriously people need to spread the word.

 

[dethkids]

Methadone and TUM's a lovely combo

So I am on MMT and am always trying new ways to make my methadone more fun. Ya know double dose, benzos, herb, etc. So today a friend at the clinic hands me a handful of tums and tells me to chew them all up. He tells me they slow down metabolism of the methadone therefore leading to more being absorbed, etc. So an hour later and WHAM! I was nodding hard. Anyone else tried tums before?

Wtf would that work with other opiates? Or xanz?

 

[dethkids]

Lemon Juice inhibits CYP450 enzymes almost as well as Grapefruit -------------------------------------------------------------------------------
(Sorry, no intent to double-post, but methinks this belongs here. PM me to request I remove anything redundant with other posts.)

http://www.ncbi.nlm.nih.gov/pubmed/18968322

Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice.​

Baltes MR, Dubois JG, Hanocq M. Talanta. 2001 Jun 21;54(5):983-7.​

​

Abstract​

... Grapefruit juice is a well-known potent inhibitor of cytochrome P450 3A4 activity. With regard to the clinical relevance of grapefruit juice-drug interactions, an investigation of other common juices is undertaken with this in vitro model.... It is demonstrated for the first time that lemon juice significantly inhibits by 60+/-3% the CYP3A4-mediated oxidation. Grapefruit juice inhibits this activity by 82+/-4%. The mechanism of lemon juice inhibition is competitive, whereas it is mixed for grapefruit juice. ...​

Lemon juice -- better, lemonade -- works almost as well as grapefruit juice at potentiating almost any opioid. (This does not apply to codeine, which works by being metabolized into morphine. Others?)

Lemon juice, like Grapefruit Juice, Cimetidine, and other substances, potentiates by inhibiting one or more of the CYP450 liver enzymes responsible for metabolism of opioids.

Star Fruit, too, among others. Useful to check specific fruits, esp. citrus, since many have some degree of inhibition.

Here is a table showing selected CYP450 substrates, inhibitors (i.e., potentiators), and inducers. Broken down by specific enzyme (e.g., 3A4 & 2D6, those most responsible for opioid metabolism; inhibiting them is good for opis):

http://www.psychresidentonline.com/CYP450 drug interactions.htm​

See also:

http://www.edhayes.com/CYP450-3.html​

http://www.aafp.org/afp/2007/0801/p391.html [TABLE 1, TABLE 2]​

What works for fetty

 

[discodolly33]

I have found black cumin seed oil to be a great potentiator, I'm not sure exactly the science behind it but i first read about it in a BL thread and have used it in combination, with H, Fent, 7Oh, hydrocodone, and codeine. I usually take about 1-2 tablespoons about 20 minutes after i've dosed. a few minutes later I feel more analgesia, my pupils will shrink up more, and a lightness in my head and any tense muscles.

 

[whereismylife]

A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal - Neuropsychopharmacology

It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce antinociception with less respiratory suppression. However, most of the adverse effects associated with opioid therapeutics are realized...

www.nature.com

Just wanted to share this interesting study. SR-17018 was extremely effective for me when using it to get clean. Just don't be a dumbass like I did at first, start taking it, keep telling yourself you'll taper off the next day, until eventually you have been taking both SR-17018 alongside Oxy and Dilaudid for weeks and are running out of all of it and running right into nasty withdrawals.... But once I got some more I wS able to use it properly I was able to completely detox without any acute withdrawals.

Researchers took morphine dependent mice and switched them to taking SR-17018. It prevented withdrawals from starting, and within a few days it completely reversed their tolerance to morphine.

Incredible RC with huge potential for tolerance reduction and for detox.

 

[andrey]

I heard that the other alkaloids present in opium have a synergistic effect with the opioids. A lot of people I talked with, said that opium is much better than morphine/codeine itself. I can imagine that some specific opioid alkaloids are better suited for it than others(like thebaine).

 

[BadBoy377]

I heard that the other alkaloids present in opium have a synergistic effect with the opioids. A lot of people I talked with, said that opium is much better than morphine/codeine itself. I can imagine that some specific opioid alkaloids are better suited for it than others(like thebaine).

Sounds about right.

Yeah, good opium will get you proper fucked up. In a really slow, heavy n pleasant way.

 

[O.B.]

Trying new opiate potentiation method
The formulation is as follows:
* T-45) 600mg Tagamet HB(Cimetidine HCl), a large glass of tonic water (or another source of quinine), and a large glass of (white) Grapefruit juice, preferably from concentrate.
* T-35) 30mg DXM HBr, 4mg CPM, 25mg Benadryl(Diphenhydramine HCl), 330mg Naproxen(Aleve).
* T-20) 2 Tums OR 1.5 Tbsp. of Baking SODA. (Obviously this step only applies if you are eating your opes)
* T-0) Parachute\chew\rail\bang your opiate\opioid.

I could have sword I saw another post in the same format, but after 3 days of searching the Megathread a few times and random searches, I can't find the one with Phenibut. I need to stretch my next script because I'll be out of state and my Dr. won't account for the extra week. So my questionion is this since I can't find the other post with a dose timer: Does this sound about right for timing and is it pushing it with the Phen? I've also got several different terpene Indica's/Indi heavy hybrid and some quality Kanna, but I don't want to nod. I fractured 3 vertabrae a while back and was on 60mg oxy IR and have managed to get myself down to 30. Idealy, I'll be able to just smoke herb, but that shows up in tests and my Dr. keeps warning me (even though it's legal for recreational use).

*T-120) 1.5g Phen HCI (Pure Raws brand)
*T-30) 800mg Tagamet and begin WGJ drinking
*T-20) 3 Tums smoothies
*T-0) crushed perc with coffee

 

[BadBoy377]

If that's your optimum dose phenibut and you're used to it then that will definitely potentiate.

I'm not sure about the WGJ. Might help might not. I've always been a little sceptical.

If it was me I'd aim for phen dose 3 hours before you drop your opiates.

 

[O.B.]

If that's your optimum dose phenibut and you're used to it then that will definitely potentiate.

I'm not sure about the WGJ. Might help might not. I've always been a little sceptical.

If it was me I'd aim for phen dose 3 hours before you drop your opiates.

I've done a couple test runs with just 1.5g Phen and 20mg perc. over the last month and while it didn't give me the euphoria we all love, it did help with taking the edge off the pain. I use to do tagamet and tums alone, but I barely noticed a difference. So my hopes are the stack I'm going to try works out. I'll push the phen out to 3 hours, I'll be able to try it once before my trip. Not a fan of WGJ, so I'm happy to drop that!

 

[BadBoy377]

Phenibut tolerance increases quickly. You might want to consider upping your dose a bit. Over time I figured out my optimum dosage was 3-4g. I increased slowly dosing once a week and upped it by 0.5g over time. I've never taken more than 4g. Ever.

Are you taking your phenibut on an empty stomach when you wake up in the morning? I found to get the best out of it that's what I had to do. Like literally before anything else, phenibut washed down with water. Then 3-4 hours later dose your analgesics and you should notice increased effects.

You could give that a go. I don't think the other would really be necessary.

 

[krodhc314]

Phenibut tolerance increases quickly. You might want to consider upping your dose a bit. Over time I figured out my optimum dosage was 3-4g. I increased slowly dosing once a week and upped it by 0.5g over time. I've never taken more than 4g. Ever.

Are you taking your phenibut on an empty stomach when you wake up in the morning? I found to get the best out of it that's what I had to do. Like literally before anything else, phenibut washed down with water. Then 3-4 hours later dose your analgesics and you should notice increased effects.

You could give that a go. I don't think the other would really be necessary.

Hello, I just found this site. I posted this on another thread. I hope I didn't break any rules. Looks like some good information and level heads for the most part. Background: I've been prescribed benzodiazepines since the 1980's. For the last 10 years my drug and dose has been Diazepam 10mg qid. Along with Gabapentin 600mg tid. I recently crossed over to Clonazepam 1mg qid and Gabapentin 800mg tid. I have been getting as many Gabapentin as I need so my unofficial dose is 2500mg to 5000mg qd. I saw an advertisement for a bottle of Phenibut 250mg and I received the bottle in post today. My question, I also take Escitalopram 20mg, Buproprion 300 xl, Dextroamphetamine 15mg bid, Clonazepam 1mg qid, Hydrocodone 7.5/325 and the Gabapentin. It has been suggested to me that taking as much Gabapentin for so long that Phenibut 250mg won't give a desired effect if any at all. What would be a safe good dosage of Phenibut to start? Will it interact with any of the meds that I have listed? If I could get some input it would be greatly appreciated. I forgot to mention I take Phenobarbital anywhere from 30mg/day to 120mg/day. My physician prescribes me Donnatal and it has 16.2mg Phenobarbital along with Hyoscyamine Sulfate 0.1037mg, Atropine Sulfate 0.0194mg and Scopolamine Hydrobromide 0.0065mg for IBS. Thank you and regards

 

[BadBoy377]

I'm not sure I'd be taking phenibut on top of all your other meds.

If I was going to I'd start low like half a gram and gradually increase by 0.5g. 1.5-2g probably be a sweet spot for you, maybe higher. Take care though. That's a lot of chemicals you're mixing.

 

[krodhc314]

I'm not sure I'd be taking phenibut on top of all your other meds.

If I was going to I'd start low like half a gram and gradually increase by 0.5g. 1.5-2g probably be a sweet spot for you, maybe higher. Take care though. That's a lot of chemicals you're mixing.

Yeah, exactly why I found this website. I like to experiment but I wanna be safe. My wife is on Buproprion 300xl and Escitalopram 20mg. She wants to try them. I may just let her see if she likes them. If she does then......I understand they are highly addictive and withdrawals are crazy horrible. Maybe, once or twice a week for her? I came off of 10mg/day of Alprazolam using only 60 diazepam 10mg. That was hell enough. Thanks for your reply.

 

[BadBoy377]

Yeah absolutely, educating yourself is the sensible thing to do for sure.

I can't really comment on the buproprion.

Phenibut withdrawal sounds horrendous and that's why I never dosed more than once a week.

 

[Syntherize]

^this. Thank you



When you potentiate via enzyme inhibition/induction, ROA is irrelevant. The potentiation occurs by 'busying' the liver enzymes that break down the drug of choice so to speak, so as long as the two chemicals get into your blood stream, it'll work... now whether or not it will potentiate it substantially is another question.

You need those enzymes in order to convert the oxycodone into oxymorphone regardless; otherwise, all you’re doing is slowing down the metabolic effects which may or may not result in a reduced opioid experience depending on your initial dose.