Coming off Invega/Xeplion (paliperidone) injections v11

[Deleted member 592205]

Antipsychotic injections should be THE LAST resource to be used while treating someone because the impact on the brain is life changing forever, but they almost use that as a first option because this is their most powerful drug and they are on hype by using that, so they push the narrative into “yeah we had to use that because there was no other way to treat the patien”

It’s like a cop: using his gun should be his last option but sometimes they use the gun as a first option. Same on psychiatry, out there are lots of psychiatry with “injections easy trigger”, because this will bring lot of money to the big pharma and they are satisfied because they “pull the trigger” giving the powerful-life changing drug. I’m sure some of them masturbate thinking the people they ruined by doing that. They are psycho.

 

[Matthew01]

It’s like a cop: using his gun should be his last option but sometimes they use the gun as a first option. Same on psychiatry, out there are lots of psychiatry with “injections easy trigger”, because this will bring lot of money to the big pharma and they are satisfied because they “pull the trigger” giving the powerful-life changing drug. I’m sure some of them masturbate thinking the people they ruined by doing that. They are psycho.

That's horrible. I want to go back to the way I was. Also please take the pictures,I really need to convince my doctor

 

[Deleted member 592205]

That's horrible. I want to go back to the way I was. Also please take the pictures,I really need to convince my doctor

It’s impossible to go back how we were before, because we don’t know the exact number of our receptors and how much They were sensible.

This drug change number and sensivity of all the receptors who are impacted, and since we don’t know our baseline exact expression we cannot go back to how things were before.

We have to say goodbye to our old self, our old lifes, and we have to assume that this door is closed forever, the best thing we can do is normalize our new expression. This is our new life, we have to take it as it is.

Even if someone will try to change our receptors expression we cannot go back to how we were before because we don’t know how thing were before, we don’t have a data about our pre-treatment expression.

Sorry for that.

 

[Deleted member 592205]

It’s impossible to go back how we were before, because we don’t know the exact number of our receptors and how much They were sensible.

This drug change number and sensivity of all the receptors who are impacted, and since we don’t know our baseline exact expression we cannot go back to how things were before.

We have to say goodbye to our old self, our old lifes, and we have to assume that this door is closed forever, the best thing we can do is normalize our new expression. This is our new life, we have to take it as it is.

Even if someone will try to change our receptors expression we cannot go back to how we were before because we don’t know how thing were before, we don’t have a data about our pre-treatment expression.

Sorry for that.

Anyways I Will try to at least try something that change my receptors expression with the university tomorrow or in the next appointoments, this is my goal, but i’m
Not an idiot and since we don’t have my pre-injections receptors expression pattern, we don’t know what my baseline is, so there is no way to go exactly how things were before.

 

[Deleted member 592205]

Anyways I Will try to at least try something that change my receptors expression with the university tomorrow or in the next appointoments, this is my goal, but i’m
Not an idiot and since we don’t have my pre-injections receptors expression pattern, we don’t know what my baseline is, so there is no way to go exactly how things were before.

Espressione is like this:

Before D2: 1’234’567 - Sensivity: 91/100
Now D2: 1’112’233 - Sensivity: 9/100

But since we cannot know the exact numbers and sensivity that was before the injection, is impossible to go back how things were before.

And this is the case of all receptors targeted by these injections, not only D2 dopamine, so I don’t know if you can understeand what the hell I’m talking about but this is something far away than even noble prize of medicine or science.

 

[InvegaInferno]

@akaz
According to the label for Invega sustenna, enzyme CYP3A4 might be important for eliminating paliperidone. It says that if you take an inducer of CYP3A4 you may need a higher dose for paliperidone to be effective. It later claims that this result is contradicted by other studies, so its unclear. You could try to induce that enzyme. Capsaicin is the only food I found online to induce that enzyme. I never tried it, and I certainly didn't want to take another drug for this purpose, but I wouldnt mind spicy food. Kind of an aside I guess, but it might be worth trying. St. John's wort is a major inducer as well, but its a drug

Paliperidone is not a substrate of CYP1A2, CYP2A6, CYP2C9, and CYP2C19, so that an interaction

with inhibitors or inducers of these isozymes is unlikely. While in vitro studies indicate that CYP2D6

and CYP3A4 may be minimally involved in paliperidone metabolism, in vivo studies do not show

decreased elimination by these isozymes and they contribute to only a small fraction of total body

clearance. In vitro studies have shown that paliperidone is a P-gp substrate.

Co-administration of oral paliperidone modified release once daily with carbamazepine 200 mg twice

daily caused a decrease of approximately 37% in the mean steady-state Cmax and AUC of

paliperidone. This decrease is caused, to a substantial degree, by a 35% increase in renal clearance

of paliperidone. A minor decrease in the amount of drug excreted unchanged in the urine suggests

that there was little effect on the CYP metabolism or bioavailability of paliperidone during

carbamazepine co-administration. On initiation of carbamazepine, the dose of INVEGA SUSTENNA

should be re-evaluated and increased if necessary. Conversely, on discontinuation of

carbamazepine, the dose of INVEGA SUSTENNA should be re-evaluated and decreased if

necessary.
Source: https://www.medsafe.govt.nz/profs/datasheet/i/invegasustennainj.pdf

 

[Matthew01]

It’s impossible to go back how we were before, because we don’t know the exact number of our receptors and how much They were sensible.

This drug change number and sensivity of all the receptors who are impacted, and since we don’t know our baseline exact expression we cannot go back to how things were before.

We have to say goodbye to our old self, our old lifes, and we have to assume that this door is closed forever, the best thing we can do is normalize our new expression. This is our new life, we have to take it as it is.

Even if someone will try to change our receptors expression we cannot go back to how we were before because we don’t know how thing were before, we don’t have a data about our pre-treatment expression.

Sorry for that.

Wait let's get information from the researcher, first. Maybe there's someone that can help.

 

[Deleted member 592205]

Wait let's get information from the researcher, first. Maybe there's someone that can help.

I’m at his level or even more of knowledge, The fact is he know what drug can change expression, i don’t, but i can also know by doing some research, The fact is we don’t have my pre-injections pattern, so is more a “blind run”, where at some point i will tell “yeah i feel like before” but even this won’t be accurate. It will only be a feeling.

 

[Deleted member 592205]

I’m at his level or even more of knowledge, The fact is he know what drug can change expression, i don’t, but i can also know by doing some research, The fact is we don’t have my pre-injections pattern, so is more a “blind run”, where at some point i will tell “yeah i feel like before” but even this won’t be accurate. It will only be a feeling.

The question is what receptors are changed in expression? D1? D2? GABA? 5HT2A? Alfa 1? Alfa 2? Norandrenaline? All of
Them? Or only some of them? Wich went downregulated and wich instead got upregulated? Can you understeand what I mean? This is some fucking noble prize thing dude, if this researcher from university can heal me and all of us, i will propose him for noble prize.

 

[Matthew01]

The question is what receptors are changed in expression? D1? D2? GABA? 5HT2A? Alfa 1? Alfa 2? Norandrenaline? All of
Them? Or only some of them? Wich went downregulated and wich instead got upregulated? Can you understeand what I mean? This is some fucking noble prize thing dude, if this researcher from university can heal me and all of us, i will propose him for noble prize.

Dopamine and serotonin are mostly responsible for emotions. There also drugs that exist that can help with this issue. Like vyvanse helped out a person in this thread and dopamine agonists

 

[Deleted member 592205]

Dopamine and serotonin are mostly responsible for emotions. There also drugs that exist that can help with this issue. Like vyvanse helped out a person in this thread and dopamine agonists

Well not feeling emotions is my last issue at the moment, i have plenty of sympthoms that emotions are not even a matter for me at this moment, my sympthoms are these:


Sleep
• Superficial, non-restorative sleep, with continuous awakenings.
• Impossible to sleep past 6AM.
• Unable to fall asleep during the day.
• Unable to feel tiredness.

⸻

Cognition
• Memory problems.
• Problem-solving difficulties.
• Concentration problems.
• Trouble completing one or more tasks without forgetting.

⸻

Perception
• Altered integration/perception of time (biological clock)
• Normal state of consciousness altered (sensation of being “high”/“feverish and dazed”).
• Absence of emotions.
• Blunted perception compared to normal.

(Diagram: before risperdal → balanced perception of past, present, future; after risperdal → narrowed perception, reduced presence in the present.)

⸻

Sexuality
• Loss of sexual desire, drastic drop in libido.
• Almost complete absence of erections (flaccid, nearly nonexistent).
• Almost complete absence of orgasms (very rare, incomplete).

⸻

Physical sensations
• Very frequent headaches.
• Strange sensations in the head.
• Muscular tension/rigidity.
• Total loss of appetite, partial hunger.
• No response to stimuli such as nicotine/caffeine.
•Tinnitus came out after 13 months

 

[InvegaInferno]

@Fake Cousin Healed ?
Recovery /ing Story

Hey guys, just wanted to drop by and give some words of encouragement to everyone on this journey.

First, some background. I was diagnosed with bipolar disorder and administered Invega Sustenna Nov October 2017. The doctors decided to increase the subsequent doses to the loading dose amount of 234mg. I received about 9 234mg shots from Nov 2016 to May 2017. Last year was complete hell. Depression, weight gain, cognitive blunting, memory impairment, social anxiety, suicidal thoughts, the whole gamut. In the summer I found this board and tried many of the remedies suggested, including st.johns wort, adderall, and the like. Nothing stopped the pain for any meaningful amount of time. I thought I was going to be in the pit for at least another year, or worse, forever.

But at 8 months since my last injection, major strides are starting to be made. The depression has lifted, as well as the social anxiety. My cognitive abilities,from general information processing to reasoning, are roaring back--maybe better than before. Physical strength still isn't where it used to be but definitely trending upward.

What was the difference, aside from time? A friend introduced me to a technique called continuous concentration. Essentially it is running a train of thought on a given object all day, from the moment one wakes up to the time one goes to bed. It's a challenge, especially with the mental blunting the Invega has caused. But after sticking with it for a few days things really started to open up. I know it may be difficult to believe, that simply "thinking your way through" can change things, but this has been my personal experience. I really feel like the worst days are behind me.

With that said, I plan to finally move on from this thread.. While I never posted much, I checked here almost everyday for solace and encouragement. I promise that one can emerge from this victorious and better from it. If anyone wants to talk more about the technique I'd be happy to go in detail. Heal quickly everyone.

 

[Matthew01]

Well not feeling emotions is my last issue at the moment, i have plenty of sympthoms that emotions are not even a matter for me at this moment, my sympthoms are these:


Sleep
• Superficial, non-restorative sleep, with continuous awakenings.
• Impossible to sleep past 6AM.
• Unable to fall asleep during the day.
• Unable to feel tiredness.

⸻

Cognition
• Memory problems.
• Problem-solving difficulties.
• Concentration problems.
• Trouble completing one or more tasks without forgetting.

⸻

Perception
• Altered integration/perception of time (biological clock)
• Normal state of consciousness altered (sensation of being “high”/“feverish and dazed”).
• Absence of emotions.
• Blunted perception compared to normal.

(Diagram: before risperdal → balanced perception of past, present, future; after risperdal → narrowed perception, reduced presence in the present.)

⸻

Sexuality
• Loss of sexual desire, drastic drop in libido.
• Almost complete absence of erections (flaccid, nearly nonexistent).
• Almost complete absence of orgasms (very rare, incomplete).

⸻

Physical sensations
• Very frequent headaches.
• Strange sensations in the head.
• Muscular tension/rigidity.
• Total loss of appetite, partial hunger.
• No response to stimuli such as nicotine/caffeine.
•Tinnitus came out after 13 months

Your loss of libido could be caused by high prolactin and low testosterone. These drugs reduce libido

 

[Deleted member 592205]

Your loss of libido could be caused by high prolactin and low testosterone. These drugs reduce libido

I have high testosterone and normal ranged prolactine, my sexual disfunction is linked to receptor expression, like my sleep and my cognition and perception of stimuli like coffe and nicotine, weed etc..

Anyways tomorrow i will talk with this researcher and push him into considering to give me drug even if its experimental trial, i don’t care. But I already know 100% that won’t prescribe nothing tomorrow, he want to talk more and maybe he will bring the senior doctor researcher to talk with me, but i will tell them that I want to start a experimental trial and i can stay in their university hospital
For experimentation.

Feel fre to PM me and explain me exactly what picture you need.

 

[Matthew01]

I have high testosterone and normal ranged prolactine, my sexual disfunction is linked to receptor expression, like my sleep and my cognition and perception of stimuli like coffe and nicotine, weed etc..

Anyways tomorrow i will talk with this researcher and push him into considering to give me drug even if its experimental trial, i don’t care. But I already know 100% that won’t prescribe nothing tomorrow, he want to talk more and maybe he will bring the senior doctor researcher to talk with me, but i will tell them that I want to start a experimental trial and i can stay in their university hospital
For experimentation.

Feel fre to PM me and explain me exactly what picture you need.

OK, I hope the drug they give you is something that is publicly available.

 

[Matthew01]

I can't live like this for the rest of my life. It's suffering

 

[rawbanana]

I can't live like this for the rest of my life. It's suffering

I feel the same way.
Feels like I’m suffering for nothing.

 

[Matthew01]

Hey risperdalconsta are they going to do that dopamine brain scan for you?

 

[Matthew01]

I feel this weird discomfort and pain in my head

 

[rawbanana]

I just can’t even imagine recovering from this