This is why everything you read about half lives for these LAI drugs is bullshit.
This is from a study of a woman who had Invega in her system 2.5 years after her last injection.
“In the initial phase we estimate that the apparent plasma half-life is 16 days, while the half-life is substantially longer in the terminal phase after hospital discharge, namely 312 days (Figure
1). This is in line with the known pharmacokinetics of intramuscular paliperidone palmitate, where approximately 20% of the dose is absorbed during the first 13 days at a constant rate and the remaining dose is absorbed afterwards following a first-order process.<a href="
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.16036#bcp16036-bib-0018" data-tab="pane-pcw-references">18</a> Helland et al. followed a patient for 19 months after discontinuation of injectable paliperidone and found an apparent elimination half-life of 142 days”
Look at how much the half life changes due to invariable factors that are basically impossible to measure. A full recovery from this drug is due to so many factors. It’s the ultimate form of human rights abuse. I believe nothing is worse than this.
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