Harmine plus ¼ of a Zoloft…part of my interest in testing the boundries of MAOIs given the absolute filth that almost everyone regurgitates about them. I also recently drank a GT Dave's kombucha a day after consuming a high dose of Parnate.
Others have been doing similar experiments on themselves, for example, this is a comment from someone who combined MDMA with moclobemide, a combination that has killed people:
1,2
"I was a reckless little shit who wanted the potentiation and because the city's biggest ER was literally across the street from these events."
3
This comment was made in a post about someone who stated he was curious about the combo and was considering doing it (MDMA & Parnate). He stated that "almost all resources on MAOIs are terribly inaccurate and over the top in their list of foods and drugs that supposedly cannot be consumed".
4 He also stated:
"The only useful resource I’ve found is Ken Gillman’s website, the expert psychiatrist on MAOIs. He recommends many drugs that are supposedly too dangerous to combine with MAOIs, yet in practice are safe. For example, I’ve read many warnings about Ritalin, but Dr Gillman shows that it is quite safe and useful on MAOIs, which I can confirm as I have tried the combination with zero impact on blood pressure. He also says that amphetamines (which have some similarities to MDMA) can also be added, but that you must be cautious while doing so, by wearing a blood pressure monitor and using small doses at first, gradually increasing the dose until you get a result or your blood pressure gets too high."
[…]
"My plan is to wear a blood pressure monitor, and take tiny doses of MDMA (1/10, say), and gradually increase over several hours, while having crisis meds available just in case such as alpha and beta blockers and Xanax."
This was the outcome of his experiment:
"The first time the effects were stronger than normal but the second time I got serotonin syndrome, blacked out and almost died, ended up in hospital."
5
I see that as a positive outcome…only because the level of misinformation about this topic is so bad it can only be compared to a children's game of telephone. Do I really want people to hurt themselves for this cause? No, but such reports add to the small arsenal that can be used against the repetitive warnings from researchers, drug users, and people involved in ayahuasca retreats. My attitude is let's look at the issue scientifically and understand what the boundries are.
Here is a quote from Ken Gillman and a supporting quote from another researcher:
"It is, unfortunately, necessary to state clearly from the beginning that much of what is published by doctors in books and journals about MAOIs is either poorly informed, or just plain wrong. As an example, much of the information that comes with MAOIs (the PI, or product information sheet) contains inaccurate material concerning, among other things: serotonin toxicity, drug interactions generally, and dietary tyramine."
6
"there is a great deal of misinformation and mythology about their dietary and drug interactions."
7
For anyone else who wants to join this cause,
my thread in the neuroscience forum is a great introduction, filled with more taboo anecdotes and some research; I also recently created
a thread on DMT-Nexus that serves as a good intro to that thread that focuses on relevant ayahuasca anecdotes.
1. Death following ingestion of MDMA (ecstasy) and moclobemide. Vuori, E., Henry, J. A., Ojanperä, I., Nieminen, R., Savolainen, T., Wahlsten, P., & Jäntti, M. (2003). Addiction (Abingdon, England), 98(3), 365–368. doi:10.1046/j.1360-0443.2003.00292.x
2. Serotonin toxicity involving MDMA (ecstasy) and moclobemide. Pilgrim, J. L., Gerostamoulos, D., Woodford, N., & Drummer, O. H. (2012). Forensic science international, 215(1-3), 184–188. doi:10.1016/j.forsciint.2011.04.008
3. [deleted account], 2019-10-19, re: Low dose MDMA while on an MAOI
4. fluffelicious, 2019-10-19, Low dose MDMA while on an MAOI
5. fluffelicious, 2022-05-27, re: Low dose MDMA while on an MAOI
6. MAOIs (Parnate, Nardil): Misconceptions and Questions No. 1. Ken Gillman, MD. PsychoTropical Research. 2012-11-14
7. Practical guide for prescribing MAOIs: debunking myths and removing barriers. 2012. Grady MM, Stahl SM. CNS Spectrums. 17(1):2-10. doi:10.1017/S109285291200003X
