Most unique drug combo you ever did?

[SuperPsych]

Lmao ill tell you anyways if you wanna hear it, one of my delusions was that I could see a few seconds into the future. Like anytime someone would do or say something id say to myself in my head ”I KNEW they would do/say that!”, in reality it was probably just some sort of intense drug induced deja vu causing me to think I was predicting these things.

Another of my delusions was that flashing lights on buildings were communicating with me, I remember filming this one building in the distance that kept blinking all night and uploaded it to all my socials thinking I was on to something deep

Other delusions/psychosis that only lasted a short while/during the most intense parts of the binge included thinking I could see through walls, communicate telepathically with souls in another world, and for the first 3 days of the bender I was also at work taking small oral dosages of 4F-MPH every morning to stay focused during the intense afterglow of the 3-MeO, I remember I got home from work my last day before vacation and staying up all night on stims and 3-MeO only to realize the music that was playing at work never stopped playing. It was all in my head and I had gotten off work 18 hours ago…

That was my last crazy bender before I got sober for good, I thought I was going to die during some points of it laying in bed at 6am tripping balls on 3-MeO while also on a-php and speed measuring my resting heartrate between 160 - 170bpm

I'm happy to hear that you've gotten sober. Sounds like you were going pretty damn hard. Though those sorts of delusions sound like par for the course with A-PHP + 3-MeO-PCP. I remember getting some delusions like what you had with the lights blinking but I can't even remember what they were anymore

 

[1998]

Harmine plus ¼ of a Zoloft…part of my interest in testing the boundries of MAOIs given the absolute filth that almost everyone regurgitates about them. I also recently drank a GT Dave's kombucha a day after consuming a high dose of Parnate.

Others have been doing similar experiments on themselves, for example, this is a comment from someone who combined MDMA with moclobemide, a combination that has killed people:^1,2

"I was a reckless little shit who wanted the potentiation and because the city's biggest ER was literally across the street from these events."³

This comment was made in a post about someone who stated he was curious about the combo and was considering doing it (MDMA & Parnate). He stated that "almost all resources on MAOIs are terribly inaccurate and over the top in their list of foods and drugs that supposedly cannot be consumed".⁴ He also stated:

"The only useful resource I’ve found is Ken Gillman’s website, the expert psychiatrist on MAOIs. He recommends many drugs that are supposedly too dangerous to combine with MAOIs, yet in practice are safe. For example, I’ve read many warnings about Ritalin, but Dr Gillman shows that it is quite safe and useful on MAOIs, which I can confirm as I have tried the combination with zero impact on blood pressure. He also says that amphetamines (which have some similarities to MDMA) can also be added, but that you must be cautious while doing so, by wearing a blood pressure monitor and using small doses at first, gradually increasing the dose until you get a result or your blood pressure gets too high."

[…]

"My plan is to wear a blood pressure monitor, and take tiny doses of MDMA (1/10, say), and gradually increase over several hours, while having crisis meds available just in case such as alpha and beta blockers and Xanax."

This was the outcome of his experiment:

"The first time the effects were stronger than normal but the second time I got serotonin syndrome, blacked out and almost died, ended up in hospital."⁵

I see that as a positive outcome…only because the level of misinformation about this topic is so bad it can only be compared to a children's game of telephone. Do I really want people to hurt themselves for this cause? No, but such reports add to the small arsenal that can be used against the repetitive warnings from researchers, drug users, and people involved in ayahuasca retreats. My attitude is let's look at the issue scientifically and understand what the boundries are.

Here is a quote from Ken Gillman and a supporting quote from another researcher:

"It is, unfortunately, necessary to state clearly from the beginning that much of what is published by doctors in books and journals about MAOIs is either poorly informed, or just plain wrong. As an example, much of the information that comes with MAOIs (the PI, or product information sheet) contains inaccurate material concerning, among other things: serotonin toxicity, drug interactions generally, and dietary tyramine."⁶

"there is a great deal of misinformation and mythology about their dietary and drug interactions."⁷


For anyone else who wants to join this cause, my thread in the neuroscience forum is a great introduction, filled with more taboo anecdotes and some research; I also recently created a thread on DMT-Nexus that serves as a good intro to that thread that focuses on relevant ayahuasca anecdotes.


1. Death following ingestion of MDMA (ecstasy) and moclobemide. Vuori, E., Henry, J. A., Ojanperä, I., Nieminen, R., Savolainen, T., Wahlsten, P., & Jäntti, M. (2003). Addiction (Abingdon, England), 98(3), 365–368. doi:10.1046/j.1360-0443.2003.00292.x

2. Serotonin toxicity involving MDMA (ecstasy) and moclobemide. Pilgrim, J. L., Gerostamoulos, D., Woodford, N., & Drummer, O. H. (2012). Forensic science international, 215(1-3), 184–188. doi:10.1016/j.forsciint.2011.04.008

3. [deleted account], 2019-10-19, re: Low dose MDMA while on an MAOI

4. fluffelicious, 2019-10-19, Low dose MDMA while on an MAOI

5. fluffelicious, 2022-05-27, re: Low dose MDMA while on an MAOI

6. MAOIs (Parnate, Nardil): Misconceptions and Questions No. 1. Ken Gillman, MD. PsychoTropical Research. 2012-11-14

7. Practical guide for prescribing MAOIs: debunking myths and removing barriers. 2012. Grady MM, Stahl SM. CNS Spectrums. 17(1):2-10. doi:10.1017/S109285291200003X

Not as crazy as some of the other answers, but meth and ativan.

What is the most unique/rare combination of different drugs you did?

Either a combination of drugs you think are very uncommonly mixed or that produced the most unique effects for you.

Ill start:
Hexen + Kratom + Weed + Salvia (chewed and smoked)
The stimulant + opioid went surprisingly well with the salvia and honestly made it incredibly euphoric compared to how it normally felt, made it more ”lucid and warm” and the salvia seemed to tint the rest of the high with a dissociating ”playful funhouse” feeling I cant even explain in words.

Honorable mention:
Zolpidem + Alcohol + Codeine + Ethylmorphine + weed + mdma + ritalin + amphetamine + benzos + antihistamines + more random pills
Just a clusterfuck of a day when I was 17 and desperately mixed everything I could find at once attempting to escape my mind, got stuck in the bathroom nodding out and talking to a wall made of melting animals in an alien language

Not as crazy as some of the other answers, but meth and Ativan.. I was doing anything to cope and not think about recent trauma

 

[GooberDoober]

They aren't rare drugs at all, but if you want unique effects look no further than LSDXM or really DXM in combo with any lysergimide. Super weird floaty, futuristic fluid like weirdness, feels like floating in an ocean that keeps flickering between two separate but similar states, very weird. Add salvia and some kappa shenanigans or nitrous, or maybe ;-) "both" and you are in for a treat. As long as you like turning into a cartoon character in an ocean of jelly and godplasma.