I'm specifically referring to Kratom alkaloids like:
7OH (hydroxymitragynine)
and pseudoindoxyl aka pseudo.
They are extremely concentrated alkaloids of kratom that are very powerful. I've seen the range of per tablet quantity of 7OH as high as 114mg per tablet and 7mg of pseudo in the same tablet. Typical commercial tabs run from 15mg per tab to 30mg per tab of 7OH or 10mg 7OH + 10mg of pseudo in a 20mg tab, but 50mg tabs are becoming more widespread.
For me, regular kratom powder capsules never did anything for opioid replacement, up to 45 capsules in 24 hours, but 7OH or 7OH + Pseudo tabs were a direct 100% replacement for oxy and morphine pills. The problem for me in pain management is over the course of 1 year of going from using up a 30 day supply of pain management Rx opioids in 15 to 20 days then completely switching to 7OH and 7OH + Pseudo until my Rx is refilled, in the last 6 weeks in the process of doing a lot more physical labor thus taking even more Rx meds until they are out then taking more 7OH and pseudo to fight WD and manage the pain associated with the physical stresses on my body, I reached a point where the stamina or "legs" or effective time span of the kratom alkaloids was 2-3 hours max at 100+mg per dose.
I started waking up every 2-3 hours overnight and had to dose or I couldn't sleep because of WD symptoms and pain. THAT was a major red flag!
That math translates to about 1,200mg per 24 hours of kratom alkaloids and that's too much.
Fortunately I read about others on this forum taking 400-800mg of 7OH and pseudo per day and the problems that caused, as well as recognizing what used to be for me a more economical way to replace my Rx meds (buying 7OH tabs) vs paying $1 per mg for Rx opioids wasn't so money saving anymore because of the short term of effectiveness and high tolerance that had developed.
I also read about people who only have taken kratom leaf powder, which has never been strong enough for me to use, going into WD and having trouble tapering down or off just that, much less the exponentially stronger kratom alkaloids.