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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 10

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My job is waiting on me but I can’t return back to it until I’m fully healed. Had to get a different job… I’m waiting.
 
Trueart2 said:
It’s mostly the cognition, I need my intellectual prowess back ASAP. It’s slowly picking up to some degree as I create this message right now I can feel some level of adequacy flowing into me when it comes to selection of verbiage/language.

I need stories that will showcase people coming back from Blank mind/ lowered cognition. I do not wish to have a blank mind for the rest of my life along with lowered intellectual prowess/ cognition.


It’s a tough day for me.
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It’s really heartbreaking. I have gone through the same thing and my ability to recall has improved slightly but it’s not how it was before.
 
InvegaAnon said:
I think it's dangerous to take an SSRI after or with invega. I know someone else who experienced the same symptoms after tapering off his medication. He got better. There's one other person as well but I don't know how she's doing. I'm mostly recovered now, just not as sensitive as I used to be in every sense of the word. Persistent memory issues too, but I've been smoking weed every day so I don't know if it's just weed at this point.
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Ok, thanks for that. I actually just finished convincing myself to just take it for the week before my period because it’s been making everything so much more tougher but having seconds thoughts again now. My doctor pretty much said to take it everyday but after looking into it I seen other people just take it for a week or 2 leading up to the date of their period and that works for them. What side effects did you experience from zoloft?
 
demileigh said:
Ok, thanks for that. I actually just finished convincing myself to just take it for the week before my period because it’s been making everything so much more tougher but having seconds thoughts again now. My doctor pretty much said to take it everyday but after looking into it I seen other people just take it for a week or 2 leading up to the date of their period and that works for them. What side effects did you experience from zoloft?
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Do you still have access to your thoughts?
 
demileigh said:
Yeah my thoughts have been coming back and my mind is blank but not as blank as it was on the injections.
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GOOD THATS THE RECOVERY. Zoloft is gonna streamline all the thoughts into one River of thought. Will intensify all existing/ co-existing thoughts.

That’s what happened to me personally.
 
There are no drugs that exist that fix receptor damage. Since drug interactions have to do with Dopamine and Serotonin and Invega causes dysfunction to those receptors.
Most people that say they recovered in less than a year are most likely lying cause biologically it takes years for a theoretical recycling to occur. As @TonyTonyChopper
has mentioned you do just get used to how things are now, I'm not sure if time is on anyone's side since any drug interaction changes your brain, nothing returns to it's previous
state it just adapts to and that adaption is how we are all living now.
If your dopamine and serotonin receptors fully recycled and resensitized, then yes — in theory your signaling could return to baseline.


The key is that “receptor recycling” here means two things happening together:


  1. Density restoration – The brain would need to upregulate D₂ and 5-HT₂A receptor numbers back to their pre-blockade levels.
  2. Sensitivity normalization – Those receptors would also need to regain normal responsiveness to neurotransmitters (not remain “numb” from chronic blockade).

If both of those happen completely, then your brain’s signaling capacity can essentially return to what it was before Invega Sustenna.
However, there are some caveats:


  • Neuroplasticity changes – Prolonged receptor blockade doesn’t just change the receptors — it can alter downstream circuits, gene expression, and even dendritic structure. These deeper changes can recover, but sometimes not 100% in everyone.
  • Incomplete upregulation – In some individuals, the receptors never fully return to their previous density or sensitivity, even after the drug is gone.
  • Functional compensation – The brain sometimes adapts in other ways (different receptor subtypes, altered synaptic strength), so even if the original receptors are back, the “feel” of brain function might not be identical to pre-drug.

In short:


  • If the receptors fully recycle → baseline is possible.
  • If they only partially recycle → you can improve a lot, but maybe not fully to the pre-Invega state.
 
Trueart2 said:
GOOD THATS THE RECOVERY. Zoloft is gonna streamline all the thoughts into one River of thought. Will intensify all existing/ co-existing thoughts.

That’s what happened to me personally.
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Yeah I’m pretty confident in my recovery as I’ve cried, can laugh and crack little jokes, saying things to make people laugh was who I was before invega and I really lost that part of myself on invega… I have expression back in my face now where before it was mask-like. Even though it’s not the same as before, I can connect to some music and even got goosebumps when chemical heart played on the radio the other week, every now and then I have songs pop into my head which is something I missed dearly about myself. Heaps of little improvements for me thankfully! Never had anxiety like I have now though and cognitive abilities aren’t as proper as they used to be, have such little motivation to do basic things too but I’m sure this will improve with time
 
brokenself said:
  • If the receptors fully recycle → baseline is possible.
  • If they only partially recycle → you can improve a lot, but maybe not fully to the pre-Invega state.
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Bro I blocked my dopamine serotonin and many other receptors from approximatly, june 2023- feb 2024. 8 full months of back to back jinvega blockade so its safe to say this rapdily upregulated my receptors. It has been 18 months since last injection and I still feel the same with some improvements recently after taking abilify 2 mg. My question is what do you think of stimulating the dopamine receptors with a partial agonist like abilify just to get them "restarted" after no activity or improvements in 18 months.
 
Invegatorture said:
Same. I just wanna escape this hell. Waking up is the worst when you know you got a whole day of suffering ahead and no joy
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bro i felt like that and worse when i was activly on the injections. the sedation , anxiety and negative feeling/thoughts will all go away after u stop the injection within few months. But real recovery takes more time but you will be there 🙏. Remember u recovered before, u will 100% recover again .
 
TonyTonyChopper said:
bro i felt like that and worse when i was activly on the injections. the sedation , anxiety and negative feeling/thoughts will all go away after u stop the injection within few months. But real recovery takes more time but you will be there 🙏. Remember u recovered before, u will 100% recover again .
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Thankyou for the support bro. It’s appreciated 🙏
 
The worst effects for me are anheondia, restlesness and fatigue. I literally spend hours every day pacing in the garden. It’s brutal. But not forever.
 
How could this happen to me? I've never done drugs in my life,I'm not psychotic or delusional. Why is this happening to me? My entire situation is beyond stupid and insane. How on earth could this happen? This is 1 in a million chance of happening. There so many things I'm supposed to be doing right now. Those horrible doctors gave me so many problems. Just why? Thinking about this situation is borderline insane. I can't even properly think because of the drugs.I don't deserve this. Those doctors should be imprisoned for life and burn in the deepest parts of hell.
 
Matthew01 said:
How could this happen to me? I've never done drugs in my life,I'm not psychotic or delusional. Why is this happening to me? My entire situation is beyond stupid and insane. How on earth could this happen? This is 1 in a million chance of happening. There so many things I'm supposed to be doing right now. Those horrible doctors gave me so many problems. Just why? Thinking about this situation is borderline insane. I can't even properly think because of the drugs.I don't deserve this. Those doctors should be imprisoned for life and burn in the deepest parts of hell.
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Yeah I didn’t even know this was possible before it happened to me. Thought a human rights violation like this was out of the question. I hope everyone involved in this practice goes straight to hell or worse
 
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