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🌟🌟 Social 🌟🌟 PD Social Thread 2022-2025 v. Year of the Phenethylamine

swilow said:
Hiw are you? I recall you working as a correctional officer- still doing that?
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I am doing mostly well. My home life is mostly stable and the only real issue I'm struggling with currently is alcoholism.
 
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swilow said:
What's news on Bl? I don't see xorkoth around, have heard he's moved on. Anyone speak to him?
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Oh yeah, Xork is fine as far as I know. I don't know how to get in touch with him, he was always here. His IRL friends have said he is well and sober and just doesn't want to deal with BL any longer. Sometimes I wonder why I stick around honestly. Things here have changed greatly but that's life I guess.
 
Cream Gravy? said:
I am doing mostly well. My home life is mostly stable and the only real issue I'm struggling with currently is alcoholism.
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Hey man, I read the text in the spoiler and recognize the feeling, I've been in situations I couldn't help before in life where I'm literally staring evil in the eye like that, but being a C.O in that context sounds absolutely traumatic. Would something like Phenibut or Pregabalin be able to substitute for ethanol, even just to some partial degree perhaps?
 
perpetualdawn said:
it's well past the placebo threshold,
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Not to split hairs, but come on. You're saying 50 µg is "well past placebo"? If anything, threshold is probably more of a range given how different people respond differently to LSD. I would say this range is 25 µg - 50 µg at its lowest. The range from 1 µg to 24 µg is not reliable discernible from placebo in my opinion, but I'm also willing to admit this is just my best conjecture versus your best conjecture until someone reliable puts out a real study and it's repeated a few times, with human volunteers at that. Think we'll see it in our lifetime though?

Haha, I just need 4 picograms and I'm trippin' fuckin' bollocks, mate! 😉 … I'm just kidding around though, it's probably not that exact of a thing and there may be other factors to consider for where this threshold is, e.g., purity, decomposition, time since last serotonergic drug use, renal pH, age, metabolism, drug use history…

it's meant to be on the edge of placebo
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No I think it's meant to be on the edge of actually tripping by staying sub-threshold. It's not represented as a placebo; it's represented as a "sub-threshold microdose".

I wonder if anyone is out there microdosing insulin… or getting their kicks from microbumps of coke. "Just a grain or two every three days and I have so much focus, bruh." I get schwasted from putting beer in a sweet breath vial and then just taking a couple drops under the tongue every other day, you see. What I do is, I dip the tip of a toothpick into a solution of 5,000 parts water to 1 part ketamine, and then I chew on it for exactly 2 minutes every eight months, and I swear, it gives me so much more creativity, lol

so why would it produce a significant and measurable result?
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Though it may be subtle, the result should still be measurable or else it's entirely ineffective and a pointless waste of perfectly good drugs. Why would someone keep doing something that doesn't produce any measurable result, then defend the practice as significant and measurably different despite all evidence pointing to the contrary? Not saying this is you, just that: you don't go to the amusement park and ask to take a micro-ride of their best rollercoaster or request that they slow it way down for you because you're going to be doing your taxes while on the ride… because that's what microdosing and half-hits of torn blotter & other scared-to-trip doses are like, to me. Doing taxes while on a slow rollercoaster that never goes any higher than a few meters.

Esperighanto said:
pure MDMB-4en-PINACA that I had on hand, just a single gram, and it became probably 10,000 or so doses? 2,100 tabs and the remainder in vape juice. What the hell am I even supposed to do with this?
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Idk, gift it to trusted friends who enjoy it?
 
unodelacosa said:
Idk, gift it to trusted friends who enjoy it?
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The safety profile of it, even though I dosed these low, still terrifies me as far as giving it to others. If I suffered some sort of damage due to my own idiocy, I'd feel much less like an evil person than if I gave it to somebody and they got fucked up about it.
 
@unodelacosa Don't worry I'm not shilling for microdosing I don't have a horse in that race at all. My only claim is that I can tell if I'm on 10µg of LSD. I'm sure this isn't that unusual. Pupnik just mentioned that he regularly doses 20µg.
 
Esperighanto said:
Would something like Phenibut or Pregabalin be able to substitute for ethanol, even just to some partial degree perhaps?
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I dunno about pregabalin, never tried it. Phenibut is gone from the vendor I used to use and also it gives me pretty bad acid reflux and stomach pains when I use it and honestly it never hit the spot like booze does anyhow.

I use kratom daily but it is more like a maintenance drug and to keep my mood stable at work.
 
perpetualdawn said:
@unodelacosa Don't worry I'm not shilling for microdosing I don't have a horse in that race at all. My only claim is that I can tell if I'm on 10µg of LSD.
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Fair enough, but at the core that still hinges on the same belief—that 10µg of LSD has a clear, noticeable effect. I’ll take your word for it and chalk it up to different sensitivities, but if I were betting, I’d say very few people on Earth—if any—can reliably and consistently distinguish 10µg from placebo more than 85% of the time. If you truly can, then hey, color me impressed, but that would make you unusually sensitive to LSD. My best guess is one of a few things: maybe you’re unknowingly taking more than 10µg (blotters are often misdosed, especially without GC-MS or a verified source, as we agreed), maybe you are just that sensitive, or maybe you're misreading placebo effects as genuine. With doses that small, even ±5µg variance is huge—it’s half the dose. And I know you've mentioned more accurate methods, but even those still rely on vendor reliability, and if you’ve ever read darknet testing reports, you’d know accuracy is all over the place. To be clear, the same caveats apply to me—I’ve got my own blind spots, and I’m not claiming I could confidently tell 10µg from placebo either, which is exactly why I don’t make that claim. :shruggies:

I'm sure this isn't that unusual. Pupnik just mentioned that he regularly doses 20µg.
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Okay, but how are you gauging what’s “unusual”? I’m not saying you’re some rare mutant, just that high sensitivity to LSD is probably uncommon—like green eyes or being left-handed. It happens, sure, but it's not the norm. Honestly, I think the recent microdosing trend has primed a lot of people to expect benefits from 10µg and then subconsciously manifest them. Not saying you’re doing that, but the logic starts from the same place: assuming 10µg has reliable effects on mood, productivity, creativity, etc., and then believing in it hard enough to experience something. The mind’s powerful like that. And to all the microdosers out there: if you think you’re gaining from 10µg, try a proper dose (on your day off, please) and compare—it might show you more. If it’s not your thing, no harm done, but at least you’ll know what it feels like to go beyond toe-dipping and actually swim.
 
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The placebo discussion is quite cool, actually. Multiple times I have identified 5 mg 2C-D as clearly psychedelic for me now. But there have been times where I wasn't on any drug which had been clearly psychedelic, or otherwise altered, too. I've always wanted to set up some experiment of having multiple equivalents of somewhat related phenethylamines (say 2C-D, B, C, maybe I) and see if I can determine which is which. But I'm all talk no walk. The same would be interesting for say 5 mg 2C-D vs nothing.
 
xdrc said:
The placebo discussion is quite cool, actually. Multiple times I have identified 5 mg 2C-D as clearly psychedelic for me now. But there have been times where I wasn't on any drug which had been clearly psychedelic, or otherwise altered, too. I've always wanted to set up some experiment of having multiple equivalents of somewhat related phenethylamines (say 2C-D, B, C, maybe I) and see if I can determine which is which. But I'm all talk no walk. The same would be interesting for say 5 mg 2C-D vs nothing.
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I've personally run blinded trials involving placebos and nocebos countless times in clandestine contexts, it shows a TON about how divergent peoples' brains can be.
 
I think I need to get dissos back into my life. Really need to keep my mood and psychiatric... defenses, so to speak, capable of maintaining themselves.
 
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Cream Gravy? said:
I think I need to get dissos back into my life. Really need to keep my mood and psychiatric... defenses, so to speak, capable of maintaining themselves.
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This is highly relatable and understandable, I'm going to try to keep ket to a 125mg dose every two weeks. 2-FDCK, PCX'S and 2-FXE are preferable but not always available, tragically. DXM is though and goddamn is it worthwhile.
 
Esperighanto said:
DXM is though and goddamn is it worthwhile.
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I’m one of those people missing or possessing too much of, whichever it is, the enzyme that metabolizes DXM. One standard medicinal dose and I had the scariest dissociative experience of my life.

Can do others no problem tho.
 
Cream Gravy? said:
I’m one of those people missing or possessing too much of, whichever it is, the enzyme that metabolizes DXM. One standard medicinal dose and I had the scariest dissociative experience of my life.

Can do others no problem tho.
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Fascinating, I wonder if it relates to the (is it CYP2D6?) enzymatic inhibition induced by Bupropion, hence the brand name Auvelity containing Bupropion and DXM together.
 
Esperighanto said:
Fascinating, I wonder if it relates to the (is it CYP2D6?) enzymatic inhibition induced by Bupropion, hence the brand name Auvelity containing Bupropion and DXM together.
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I’m not sure, after that one experience when I was sick back in 2013 I haven’t really bothered to read about DXM. Like I said, it was quite disturbing. But it was also like I could rationalize that I knew it was the medicine and convince myself to go back to sleep which was good. Never really looked back after that.
 
Cream Gravy? said:
I’m not sure, after that one experience when I was sick back in 2013 I haven’t really bothered to read about DXM. Like I said, it was quite disturbing. But it was also like I could rationalize that I knew it was the medicine and convince myself to go back to sleep which was good. Never really looked back after that.
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Reminds me of the time back in 2000 when I ate 18 Dramamine. Not a good time, not recommended. Lol.

It's also interesting to me that levomethorphan (LVM), the opposite optical isomer of dextromethorphan (DXM), is not a disso but rather an opioid with affinity mostly for the delta- and kappa-opioid receptors. Methorphan is the racemate.
 
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