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Stimulants can you inject Lisdexamfetamine

daves004s said:
Hi there 'i just would love to no if you can inject


Lisdexamfetamine as it is water soluble ? thanks guys as it would be a great help as a mate of mine wants to do it n im just worried it to cuase harm to him.. cheers​


Lisdexamfetamine​

Click to expand...

It’s a prodrug meaning it has to go through first pass metabolism. It may have activity on its own. Idk. But as far as I know it needs to go through the liver before it converts to dextro amphetamine?
 
vyvanse, lisdexamfetamine, is a prodrug for d-amphetamine which requires an enzyme found in the blood for conversion

this conversion is limited by enzyme kinetics so even if a large bolus is given through IV it will still take over an hour to reach maximum d-amphetamine concentration
 
helpingout said:
It’s a prodrug meaning it has to go through first pass metabolism. It may have activity on its own. Idk. But as far as I know it needs to go through the liver before it converts to dextro amphetamine?
Click to expand...
Iirc lisdex in metabolised in the bloodstream rather than the liver so injecting would probably work but not increase speed of onset or intensity.

I wouldn't try it though. Most of what's in the capsule is binder which nobody wants to be injecting.
 
The absolute oral bioavailability of lisdexamfetamine is close to
100% (96.4% of radioactivity was recovered in a human 0-120hr urine collection).
Bioequivalence was shown for the fed versus fasting state. The bioavailability of
lisdexamfetamine clearly meets the biopharmaceutics classification system (BCS) criteria for
a highly permeable drug
 
Shinji Ikari said:
so injecting would probably work but not increase speed of onset or intensity.
Click to expand...
From the research I did before requesting the switch to vyvanse from Ritalin IR, I remember reading about the ways certain users could or might try to bypass the "pro drug release mechanism".

And the quote above ledas to the one below

Pissed_and_messed said:
The absolute oral bioavailability of lisdexamfetamine is close to
100% (96.4% of radioactivity was recovered in a human 0-120hr urine collection).
Click to expand...

Summary


Taken orally as prescribed gives the strongest, best distribution/cleaving of the lysine to release the right amount of dex at the right pace and intervals.

Snorting/injecting or any other method would still get a weakened effect, but in the same breakdown method the design of the drug is formulated for regardless of ROA.

An even amount of dex delivered into the system working for 10+ hours at the right strength. Every time, 100% the most impressive formulation I have seen. For a "single dose" taken in the early morning once a day.

Just to be clear not every day is " full of roses" and sometimes one feels lethargic even on the meds, but with the right amount of sleep every night this can be avoided to the point of it being a non issue.
 
Last edited:
helpingout said:
It’s a prodrug meaning it has to go through first pass metabolism. It may have activity on its own. Idk. But as far as I know it needs to go through the liver before it converts to dextro amphetamine?
Click to expand...

someguyontheinternet said:
vyvanse, lisdexamfetamine, is a prodrug for d-amphetamine which requires an enzyme found in the blood for conversion

this conversion is limited by enzyme kinetics so even if a large bolus is given through IV it will still take over an hour to reach maximum d-amphetamine concentration
Click to expand...
Ya i just read it as it has lysine in it which is the extra step it need to make the drug actaive, cheers guys it means alot eh..
Take care n don't do anything io would pmsl
HAVE A GREAT DAY MATE thanks again !
 
Pissed_and_messed said:
The absolute oral bioavailability of lisdexamfetamine is close to
100% (96.4% of radioactivity was recovered in a human 0-120hr urine collection).
Bioequivalence was shown for the fed versus fasting state. The bioavailability of
lisdexamfetamine clearly meets the biopharmaceutics classification system (BCS) criteria for
a highly permeable drug
Click to expand...
Your a legend Bro and after googling a few of the words you wrote heir iv even learnt a great deal my good man, cheers from sydney nsw ..
 
shreddedlettuce said:
From the research I did before requesting the switch to vyvanse from Ritalin IR, I remember reading about the ways certain users could or might try to bypass the "pro drug release mechanism".

And the quote above ledas to the one below



Summary


Taken orally as prescribed gives the strongest, best distribution/cleaving of the lysine to release the right amount of dex at the right pace and intervals.

Snorting/injecting or any other method would still get a weakened effect, but in the same breakdown method the design of the drug is formulated for regardless of ROA.

An even amount of dex delivered into the system working for 10+ hours at the right strength. Every time, 100% the most impressive formulation I have seen. For a "single dose" taken in the early morning once a day.

Just to be clear not every day is " full of roses" and sometimes one feels lethargic even on the meds, but with the right amount of sleep every night this can be avoided to the point of it being a non issue.
Click to expand...
Very interesting thanks so very much my friend..
and thank you for your time as it means alot, your all such good ppl heir, you truly are. anyhoo thanks again n you take care Cheers.
 
Shinji Ikari said:
Iirc lisdex in metabolised in the bloodstream rather than the liver so injecting would probably work but not increase speed of onset or intensity.

I wouldn't try it though. Most of what's in the capsule is binder which nobody wants to be injecting.
Click to expand...
I think Google said the intestines after i really starting ressurching., cheers anyway mate
 
I read a medical journal comparing oral Lisdexamfetamine, IV injection, insulfating etc

Oral and IV are approximately the same C-Max being 3 hours 70mg Vyvanse……150-200,g Vyvanse was 4.5h until C-max reached

Lisdexamfetamine obviously needs to enter the bloodstream were trypsin cleaves the molecule into Lysine and the API being d-Amphetamine (Dexedrine)

Ritalin (Methylphenidate) is easily the best
Amph (Adderall IR & XR are amazing meds 75% dextro / 25% levo
Dexedrine IR and Spansules are classic
Desoxyn (d-Methamphetamine) 5mg tablets (20-25mg) is a fabulous option, probably the safest in adult adhd cardiovascular speaking

Ritalin is my favourite med

I’ve had Vyvanse 40mg (12mg of d-Amph) peaking 3h lasting 8-10 hours …..was ok, but Methylphenidate was far more agreeable
 
just got some vynase. I'm not a heavy stim user.

what would be a good dose just for clean energy, not insane energy
 
crOOk said:
Indeed a maxim fit to grace the gravestone and verily one the sages themselves would doff their caps to.
Click to expand...

Still waiting for some genius to ask if they can IV nitrous oxide.

I'm also at once fascinated and freaked out by people who will put anything into a pin. Even where there are other ROAs that are both faster and achive higher concentrations within the BBB.

I suspect THAT is an artifact of people failing to understand that you cannot presume that blod plasma levels reliably provide insight into the subjective experience of consuming a drug.

But I did know a couple of chancers who figured out how to base the methadone out of the linctus and vape it. All I know is that for a while they were always seen standing outside pharmacies that filled the blue prescriptions but within weeks, both just disappeared. I do not know where to, but I don't expect it was anywhere good.
 
4DQSAR said:
Still waiting for some genius to ask if they can IV nitrous oxide.

I'm also at once fascinated and freaked out by people who will put anything into a pin. Even where there are other ROAs that are both faster and achive higher concentrations within the BBB.

I suspect THAT is an artifact of people failing to understand that you cannot presume that blod plasma levels reliably provide insight into the subjective experience of consuming a drug.

But I did know a couple of chancers who figured out how to base the methadone out of the linctus and vape it. All I know is that for a while they were always seen standing outside pharmacies that filled the blue prescriptions but within weeks, both just disappeared. I do not know where to, but I don't expect it was anywhere good.
Click to expand...
Well I can understand why people would want to inject anything that can be put into solution, having IV'ed amphetamine (uncut) for a few years which doesn't really provide any added benefit and induces injury like injecting any other drug. It was more about the brief feeling of control over the state I am in than about the effects. Fortunately I don't have that urge anymore these days and will only IV drugs when the effects are subjectively superior to other ROA's.
 
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