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  • BDD Moderators: Keif’ Richards | negrogesic

Meth lisdexamfetamine reduction regime for acute methamphetamine withdrawal

tryptakid said:
The biggest difference between meth and dextroamphetamine is the lack of SERT agonism and the presence of increased norepinephrine. Meth is less stimulating in therapeutic dose ranges, but the serotonin release from higher dose use (I believe over 25 or 30mg) blends with the dopaminergic effects to create a unique euphoria which is less self-limiting. The norepinephrine released by dextro/levo-amphetamine (and vyvanse which becomes dextroamphetamine) increases stuff like muscle tension and likely leading to that wired/jittery feeling.

That said, continuing with the vyvanse while also being on the desvenla will probably be broadly enough to land the plane, but it will not feel as smooth as meth.

If you can trust yourself with a small amount of oral methamphetamine concurrent with your vyvanse, it could be helpful, but I would only do this if you have a solid plan and failsafe to prevent lapsing back into ongoing use.

If you can also utilize N-Acetyl Cystine, that may help with compulsivity and urge to continue to use stimulants.

What's your ultimate goal here? Will you continue to be able to access the vyvanse for a period of time and taper down?
Click to expand...
Well put....

Unfortunately for the poster....they don't reside in Canada

There is a vendor who has damn near pharmaceutical grade 4-MMC (Mephedrone)

4-Methyl-Meth Cathinone HCL
500% increase in Dopamine
900% increase in Serotonin

Very subtle in low therapeutic doses, with robust mood-boosting properties. Euphoric & pleasurable.

Only ships within Cananda ....no customs to clear, shipped right to your front door XpressPost.

Perhaps not the best route considering your Methamphetamine dependence & withdrawal....but paired with your Vyvanse (Lisdexamfetamine) 3h onset / 10h duration the 4-MMC would give you the required SERT/DAT to taper off gradually

Minimizing mental depression & cognitive impaired and other unpleasant symptoms

But perhaps just Vyvanse is best? Your CNS will gradually go back to "normal"

I was on Vyvanse for a while....decent I guess. I strongly prefer the rapid acting Ritalin (Methylphenidate) 3-4h duration

Perhaps Vyvanse + Lyrica (Pregabalin) 300mg would be more comfortable as your taper

Good luck with the taper
 
tryptakid said:
The biggest difference between meth and dextroamphetamine is the lack of SERT agonism and the presence of increased norepinephrine. Meth is less stimulating in therapeutic dose ranges, but the serotonin release from higher dose use (I believe over 25 or 30mg) blends with the dopaminergic effects to create a unique euphoria which is less self-limiting. The norepinephrine released by dextro/levo-amphetamine (and vyvanse which becomes dextroamphetamine) increases stuff like muscle tension and likely leading to that wired/jittery feeling.

That said, continuing with the vyvanse while also being on the desvenla will probably be broadly enough to land the plane, but it will not feel as smooth as meth.

If you can trust yourself with a small amount of oral methamphetamine concurrent with your vyvanse, it could be helpful, but I would only do this if you have a solid plan and failsafe to prevent lapsing back into ongoing use.

If you can also utilize N-Acetyl Cystine, that may help with compulsivity and urge to continue to use stimulants.

What's your ultimate goal here? Will you continue to be able to access the vyvanse for a period of time and taper down?
Click to expand...

The SERT activity in both D-methamphetamine and dextroamphetamine is about the same, with D-methamphetamine being barley more potent then dextroamphetamine, not really enough to make a huge difference.

The addition of the extra methyl group makes the methamphetamine more nonpolar. This allows it to quickly cross the nonpolar barrier between our blood vessels and brain, causing it to have more pronounced effects on your body. Also Methamphetamine's stronger action on VMAT2 (vesicular monoamine transporter 2) results in higher dopamine release, which contributes to its stronger euphoric effects.
 
Last edited:
@bablyonee Hi! A product I always recommend to opioid and stimulant user's is black seed oil, it not only helps withdrawal from both but also lowers tolerance too.
So it'd help your amphetamine use in the future.
I use it all the time for my opioid use.

@tryptakid You mentioned N-Actyle-Cysteine and said it helps with compulsivity when it comes to use.
I'm guessing it helps this way too with opioids?
Is there much research backing this up?
All I know is that it's given for acetaminophen/paracetamol overdoses cause it's a precursor to glutathione, a powerful antioxidant that works a lot (Primarily?) in the liver and Milk Thistle causes the liver to research it.
 
Gaz_hmmmm said:
@bablyonee Hi! A product I always recommend to opioid and stimulant user's is black seed oil, it not only helps withdrawal from both but also lowers tolerance too.
So it'd help your amphetamine use in the future.
I use it all the time for my opioid use.

@tryptakid You mentioned N-Actyle-Cysteine and said it helps with compulsivity when it comes to use.
I'm guessing it helps this way too with opioids?
Is there much research backing this up?
All I know is that it's given for acetaminophen/paracetamol overdoses cause it's a precursor to glutathione, a powerful antioxidant that works a lot (Primarily?) in the liver and Milk Thistle causes the liver to research it.
Click to expand...
Most of what I know if it's use is anecdotal reports however there has been some research demonstrating a reduction in drug craving behavior when using NAC - here's a paper discussing N-acetylcysteine in the treatment of craving in substance use disorders: Systematic review and meta-analysis
 
tryptakid said:
Most of what I know if it's use is anecdotal reports however there has been some research demonstrating a reduction in drug craving behavior when using NAC - here's a paper discussing N-acetylcysteine in the treatment of craving in substance use disorders: Systematic review and meta-analysis
Click to expand...

That's not just a paper discussing it, that's a meta study!
They can be very good for finding evidence as they study multiple studies.
Thank you!
I'll be purchasing some NAC in the future.
 
Gaz_hmmmm said:
It doesn't work, it's need some kind of plug in for the browser I assume.
Click to expand...
Ah, yeah, it's a plugin that uses sci-hub (which should should be able to pull up via websearch) - just search for the title/article info there and it should bring you to a non-paywalled article.
 
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