Antipsychotics, strength and opinions.

[MedicinalUser247]

I'm posting because I want your opinions about Antipsychotics. I just want to give my opinion on some and what you think about it. One thing is a list from strongest to weakest. Most commonly prescribed Antipsychotics from strongest to weakest. Clozapine, pimozide, fluphenazine, trifluoperazine, haloperidol, chlorpromazine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, brexpiprazole, prochlorperazine. As for longest acting, but not on the market "penfluridol" the dosage for that is one pill every 7 days. In my opinion clozapine augmented with penfluridol would be the most effective treatment of psychosis. Also, lithium augmented with that would be the best for mood stabilization, if with a psychosis. What do you think ?

 

[AlsoTapered]

Psychomedicine is a very rarified field. Their is no right answer and in reality, a psychiatrist is guided to a person's response to such classes of drug. Psychologists can sometimes produce coping mechanisms that allows the reduction in the amount of medicine needed..

 

[MedicinalUser247]

Well... When it comes to Atypical antipsychotics Clozapines the best. When it comes to the older neuroleptics Chlorpromazine is the best way to go. As for Haldol the stuff is awful it makes you shake and gives you bad akathisia. Any high potency neuroleptic usually has the most side effects and low potency ones have the least.

 

[foodcrisis]

i found that my voices and sounds were mostly if not entirely gone while taking risperdal pills... on quetiapine pills mixed with some other drug as pills i can't remember, i think i still had some symptoms of auditory hallucinations, but probably less... recently i got prescribed haldol injections mixed with zyprexa and right when i got out of the hospital after being there for 3 months, i started to hear these weird what i'll call "electrical explosions" from miles away, they definitely weren't real. i started smoking weed right when i got home and the voices came back. i was smoking a bunch of weed on risperdal and wasn't getting voices or any sounds. the psychiatrist i'm seeing now was actually saying my dose of haldol injections and zyprexa doses were on the higher end too.... those are the only anti-psychotics i've been subjected to and i hope that i don't have to try anymore or go on any i've tried again.

i've never had bad experience with haldol injections other than injection site pain and being a little tired or gross feeling the day after on higher doses. not bad for only having to deal with one dose every 28 days. a lot easier for me to deal with than some other drugs... the thing is it didn't really work like it's supposed to for me, not that i even wanted to get rid of my hallucinations. i'm glad it didn't work tbh. not sure how many posters or readers are actually using anti-psychotics to stop schizophrenia... like i said, i made a thread wondering about drug users with schizophrenia and the percentage of people that actually have auditory hallucinations is a lot less than i would've expected...

 

[MedicinalUser247]

If you can handle Haldol well good for you. Me I can't stand the stuff and I prefer taking Clozapine. But everyone has a different response to different medications.

 

[MedicinalUser247]

Well... When it comes to antipsychotics I find a few that work really good. One is Clozapine the second is Olanzapine the third is Quetiapine and the fourth is Chlorpromazine. It's kind of funny. The antipsychotics that work the best for me are all structurally related. Except for Chlorpromazine which is phenothiazine, but that works just as well. I actually enjoy taking Chlorpromazine because it's so relaxing.

 

[MedicinalUser247]

Hypothetically, If I had to go on a High Potency Neuroleptic I'd probably go with Trifluoperazine. It has not only antipsychotic effects, but antianxiety effects as well. Probably because of it's antiadrenergic action a long with it's antidopaminergic effects.

 

[izo]

I hated olanzapine at 15mg but really liked 5mg haloperidol or a standard dose of quetiapin or prothipendyl…

 

[Juicewrldfan]

I didn’t take it for psychosis but cariprazine I had a love hate relationship with. It was great for motivation and extremely effective at increasing libido surprisingly yet the downsides were increasing aggression and it got bad. Maybe a bit of akathesia. But man sometimes I think about trialing a lower dose though I was on the starter dose.

 

[MedicinalUser247]

I have question. Why is Penfluridol off the market ? It seems like a good idea to me. Just take one pill and it lasts for seven days. How come it's discontinued ?

 

[blazR]

Because of it's side-effects;

"It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism."

From wiki..

 

[MedicinalUser247]

What's your favorite Antipsychotic ?

 

[paranoid android]

What's your favorite Antipsychotic ?

Thorazine or compazine mixed with morphine not only boosts analgesia but also euphoria by quite abit imo

 

[3DQSAR]

I've read that quietipine is abused by prisoners. I believe the explanation is that convicts can 'sleep through your sentence' although on a personal level, I found the stuff to be awful and yet there are individuals who will pay cash money for the stuff - which proves how crazy some people are.

I've even heard of people mixing it with cocaine and injecting said mixture. I believe the term 'slowball' is used to describe the mixture.

All I know is that people prescribed antipsychotics long-term can expect increased chances of developing neurodegenerative diseases later in life.

Now I've known people who quite clearly needed such medicines but I have noted that a few people to suffer from schizophrenia or related conditions who are sufficiently self aware to use such medicines as needed. Not every single day.

The fact that they are so dirty is only accepted because they are generally reserved to those struggling with severe mental illness.

 

[Jnowhere]

Thorazine or compazine mixed with morphine not only boosts analgesia but also euphoria by quite abit imo

Thorazine especially and other early anti psychotic drugs and even other newer ones also can have potentially lifelong side effect. Also other bad side effects

Tardive Dyskinesia in particular. This was alluded too and mentioned( not specifically) in a earlier post, by someone who saw this before me.

This neurological disease, is usually life long. It can happen with shorter term use but especially with long term use especially in people 65+ y.o.. This can happen to younger people also.

It can cause lifelong muscle movements, especially in the mouth.
It can be treated in some people, but using antipsychotic meds recreationally is a bad idea.

They are no fun by themselves, as many have told me. And risking it for recreational purposes; once again is a bad idea.

Compazine, I saw a person I knew very well; who was given it, off label for a non psychiatric reason, and go ape shit crazy from it and ended up leaving the restaurant, about to explode and walked at least 5 miles to get home and have it wear off.

These drugs as mentioned are not to be taken recreationally and only if really needed.

Why do you think you might need them?

Also, there should be potential risks and side effects listed. Doctors often don't know and/or care.

If you really need them, check them out thoroughly. Don't risk messing yourself up permanently if they are not really needed, bro.

,

 

[3DQSAR]

I found tardive dyskinesia a little unsettling when first I saw it. The person who displayed this symptom was prescribed haloperidol. To my shame I did suggest that maybe the individual in question might wish to ask their consultant if a more modern neuroleptic might be more appropriate. Well, over the next few years the person went from being almost painfully thin to being morbidly obese.

I had presumed that their consultant would be aware of the side-effects of atypical neuroleptics but I possibly overstated how much patients with such symptoms are monitored. It seems they aren't.

I haven't seen that person for a few years now, but I would like to know that they are still in the land of the living.

 

[Jeanpauldash]

I had a mental hospital give me an anti psychotic that put me in extreme physical pain. I couldn't remember my own name or who I was. I had to throw it in the toilet to save my life.

 

[3DQSAR]

Thorazine especially and other early anti psychotic drugs and even other newer ones also can have potentially lifelong side effect. Also other bad side effects,

Thorazine (chlorpromazine) and Haldol (haloperidol) were the first two neuroleptics to receive GSLs and the latter, at least, it still used in psychiatric emergencies here in the UK. It's commonly used as part of a cocktail referred to as a 'B52' which is, as the nickname suggests, 5mg of haloperidol and 2mg of lorazepam.

I don't know how chlorpromazine was discovered* but haloperidol was the result of Janssen experimenting with pethidine derivatives. It was noted that increasing the chain length of the N-alkyl spacer resulted in compounds that produced 'a sustained and profound sedation'. I mean, you can't test exactly what a rat is experiencing, But evidently this was unexpected, especially since tests showed that it wasn't due to opioid activity.

But even now we still do not have a full understanding of how neurolrptics work and there have been some frankly ludicrous claims made for the ever expanding number of drugs in the class. I think my favourite was that bromperidol was of particular value in the treatment of 'deviant sexual behaviour' which I suspect was based purely on the fact that it contains an aryl bromide moiety.

*History of the discovery and clinical introduction of chlorpromazine
Francisco López-Muñoz, Cecilio Alamo, Eduardo Cuenca, Winston W Shen, Patrick Clervoy, Gabriel Rubio
Ann Clin Psychiatry . 2005 Jul-Sep;17(3):113-35
doi: 10.1080/10401230591002002

Always be careful of such histories. In my experience they are often subject to a certain amount of revisionism. If you can read the original lab notes, they are sometimes at odds with the 'official' history. In the 1950s, serendipity was a significant factor.

 

[Smyth2]

I have that article.

Francisco López-Muñoz was always very informative.

 

[Liser]

In my case I have tried practically all the antipsychotics that are available right now and doctors can prescribe. And Trying different doses of an antipsychotic and making mixtures of several doses at the same time and mixures of different antipsychotics, with other types of psychotropic drugs.