Will this one day come out in the news / internet anyway??
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Professor Nutt's magic jizz (Sentia)
- Thread starter StoneHappyMonday
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Bluelighter
Still shilling this shite? Jesus Christ, give it a rest.
Yup shilling. Keeping it to the relevant thread though
Looks like this GP had magic jizz too:
A GP in England has been found guilty of a sexual offence after he deposited his semen into a woman’s coffee. The victim told a trial she would pour ‘salty’ coffee away but always noticed a ‘thick, gloopy’ substance in the sink.
Dr Nicholas Chapman, 55, filled up hundreds of ‘specimen’ samples and was accused of dropping them into his victim’s hot drinks on multiple occasions over the course of a year. The victim - who hasn’t been named for legal reasons - became suspicious when she discovered a collection of the samples a year later
A GP in England has been found guilty of a sexual offence after he deposited his semen into a woman’s coffee. The victim told a trial she would pour ‘salty’ coffee away but always noticed a ‘thick, gloopy’ substance in the sink.
Dr Nicholas Chapman, 55, filled up hundreds of ‘specimen’ samples and was accused of dropping them into his victim’s hot drinks on multiple occasions over the course of a year. The victim - who hasn’t been named for legal reasons - became suspicious when she discovered a collection of the samples a year later
Morning cuppa
Bleaney
Bluelighter
- Joined
- Mar 13, 2021
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His defence could be that he did ask her if she wanted cream in her coffee (fnarr fnarr!), and it's all just been a massive misunderstanding.
This would be better than his actual defence, which is claiming that he has a rare medical condition which makes him ejaculate when he takes a shit. Seriously. That is the defence he is going with.
Apparently that disorder is an actual thing, but on the remotest chance that he actually had it, that would mean that he didn't wash his hands after spaffing everywhere whilst having a shit, and / or that he took the coffee cups into the toilet with him. Pretty gross all round whatever the case.
Surely he'll have to prove that he has that disorder for his defence to have any chance.
I'd say he's guilty just because he looks even more of a creepy weasel than Michael Gove, and I'd be surprised if some revelations or other don't come up in connection with him.
That defence is mentioned in this article I posted In gibberings a few days ago, although it now looks he's deciding to use the defence of "it was just a prank"
The phrase 'clutching at straws' springs to mind.
www.joe.co.uk
This would be better than his actual defence, which is claiming that he has a rare medical condition which makes him ejaculate when he takes a shit. Seriously. That is the defence he is going with.
Apparently that disorder is an actual thing, but on the remotest chance that he actually had it, that would mean that he didn't wash his hands after spaffing everywhere whilst having a shit, and / or that he took the coffee cups into the toilet with him. Pretty gross all round whatever the case.
Surely he'll have to prove that he has that disorder for his defence to have any chance.
I'd say he's guilty just because he looks even more of a creepy weasel than Michael Gove, and I'd be surprised if some revelations or other don't come up in connection with him.
That defence is mentioned in this article I posted In gibberings a few days ago, although it now looks he's deciding to use the defence of "it was just a prank"
The phrase 'clutching at straws' springs to mind.
Doctor 'sexually assaulted woman by putting his semen into her cups of coffee'
‘He had been attempting to engage her in a form of sexual activity – by her ingesting his semen’A doctor...
www.joe.co.uk
Last edited:
Is This the Future of Non-Alcoholic Drinking?
If it works, the synthetic compound Alcarelle will provide a non-boozy buzz
www.insidehook.com
AlsoTapered
Bluelighter
It will be interesting to read any GABA labs patents BECAUSE I sent the QSAR for both 1,4-benzodiazepines and 1,5-benzodiazepines that are a5 selective... and Nutt replied to my E-mails. So IF they attempt to patent any of the compounds I designed, I actually have proof that they are not novel (so cannot be patented.
I've mentioned pyeyzolam which was my first design and GABA labs (under it's previous name 'Alcorette') paid me for the rights (and I have copies of said sale) BUT it only covers 3 specific compounds i.e.
Pyeyzolam - a5-selective benzo that emulates 'drunk' but cannot emulate '2 glasses of wine' i.e. I discovered the receptor that high doses of ethanol bind to.
Pynazolam - a benzo that is actually a selective serotonin releaser which emulated the relaxation and euphoria ethanol produces.
Pynazolam - which the above were both made from.
But I later figured out that lower doses of alcohol preferentially bind to the a5b2y2 receptor and sent Nutt the design for Pyeybazam which has been made and tested and DOES emulate lower doses of ethanol.
So to emulate alcohol from 1 glass of wine to a bottle of vodka actually required 2 different compounds, specifically a 3:1 mixture of Pyeybazam
yeyzolam. Now, getting a marketing licence when their are 2 actives is just HUGELY costly.
So what did I do next? I found a compound that acted at both the a5b1y2 AND a5b2y2 GABA receptors. Now THAT they do not have. It took the team a fair old while to figure out how to produce an asymmetrical dimer (so technically not a dimer but chemists will know what I mean). It required an unusual synthetic technique and even then the product wasn't pure and required biocatalytic resolution (the impurities cannot be removed using HPLC or any other purely chemical technique).
I should add we didn't DISCOVER this method or resolving mixtures but knowing the appropriate biocatalyst and conditions resulted in a LOT of trial end error. But if people wish to see pyeyzolam, pynazolam and pyeybazam, here they are:
So the only things I'm not showing is the single chiral compound that is a5b1y2/a5b2y2 selective and which about 5mg equals 1 UK unit of alcohol.
Of course it's quite possible that GABA Labs are working with an entirely new scaffold. The most obvious one to me is those found in Kava, specifically kavain, dihydrokavain and methysticin although out limited studies showed that the natural compounds are VERY costly to extract so they would have to produce them synthetically and the law is much laxer on natural compounds as compared to synthetics. We did briefly think that it's impossible to tell if a given compound was produced by a plant or by synthesis but that IS dubious legal ground and if anyone remembers tryptophan being banned. The Chinese were CLAIMING to have extracted it from plants but were in fact making it synthetically and as it turned out, their was an impurity that turned out to be chronically toxic.. so we gave up on that one.
I've mentioned pyeyzolam which was my first design and GABA labs (under it's previous name 'Alcorette') paid me for the rights (and I have copies of said sale) BUT it only covers 3 specific compounds i.e.
Pyeyzolam - a5-selective benzo that emulates 'drunk' but cannot emulate '2 glasses of wine' i.e. I discovered the receptor that high doses of ethanol bind to.
Pynazolam - a benzo that is actually a selective serotonin releaser which emulated the relaxation and euphoria ethanol produces.
Pynazolam - which the above were both made from.
But I later figured out that lower doses of alcohol preferentially bind to the a5b2y2 receptor and sent Nutt the design for Pyeybazam which has been made and tested and DOES emulate lower doses of ethanol.
So to emulate alcohol from 1 glass of wine to a bottle of vodka actually required 2 different compounds, specifically a 3:1 mixture of Pyeybazam
yeyzolam. Now, getting a marketing licence when their are 2 actives is just HUGELY costly.So what did I do next? I found a compound that acted at both the a5b1y2 AND a5b2y2 GABA receptors. Now THAT they do not have. It took the team a fair old while to figure out how to produce an asymmetrical dimer (so technically not a dimer but chemists will know what I mean). It required an unusual synthetic technique and even then the product wasn't pure and required biocatalytic resolution (the impurities cannot be removed using HPLC or any other purely chemical technique).
I should add we didn't DISCOVER this method or resolving mixtures but knowing the appropriate biocatalyst and conditions resulted in a LOT of trial end error. But if people wish to see pyeyzolam, pynazolam and pyeybazam, here they are:
So the only things I'm not showing is the single chiral compound that is a5b1y2/a5b2y2 selective and which about 5mg equals 1 UK unit of alcohol.
Of course it's quite possible that GABA Labs are working with an entirely new scaffold. The most obvious one to me is those found in Kava, specifically kavain, dihydrokavain and methysticin although out limited studies showed that the natural compounds are VERY costly to extract so they would have to produce them synthetically and the law is much laxer on natural compounds as compared to synthetics. We did briefly think that it's impossible to tell if a given compound was produced by a plant or by synthesis but that IS dubious legal ground and if anyone remembers tryptophan being banned. The Chinese were CLAIMING to have extracted it from plants but were in fact making it synthetically and as it turned out, their was an impurity that turned out to be chronically toxic.. so we gave up on that one.
Does that mean they are in the public domain?
AlsoTapered
Bluelighter
Well, the compounds I've shown were the ones sold to Nutt (Alcorette) and patented so yes, they are in the public domain.
If they are not patented then can anyone use them?
I thought it you sold them then only the buyer could use them.
AlsoTapered
Bluelighter
Yes - you asked if they were in the public domain which they are. All patents are in the public domain BUT ownership of the intellectual property is in the hands of Alcorette AKA GABA Labs.
But since it's very specifically JUST those 3 compounds, one can easily develop an analogue that isn't patented. If you want a legal-to-produce pyeyzolam homologue, just add a 4-methyl thus:
Call it mepyeyzolam or something.
You see the thing is that it wasn't so much the specific compound, it was IDENTIFYING that the a5b1y2 subtype is responsible for all of the positive effects of alcohol.
Oh, and MOST of the negative effects (all the emotional and behavioral ones) are mediated by the a1b1y2 subtype.
But since it's very specifically JUST those 3 compounds, one can easily develop an analogue that isn't patented. If you want a legal-to-produce pyeyzolam homologue, just add a 4-methyl thus:
Call it mepyeyzolam or something.
You see the thing is that it wasn't so much the specific compound, it was IDENTIFYING that the a5b1y2 subtype is responsible for all of the positive effects of alcohol.
Oh, and MOST of the negative effects (all the emotional and behavioral ones) are mediated by the a1b1y2 subtype.
Bottom line.. does this help the cause to release this alcarelle, or add another hurdle?Yes - you asked if they were in the public domain which they are. All patents are in the public domain BUT ownership of the intellectual property is in the hands of Alcorette AKA GABA Labs.
But since it's very specifically JUST those 3 compounds, one can easily develop an analogue that isn't patented. If you want a legal-to-produce pyeyzolam homologue, just add a 4-methyl thus:
Call it mepyeyzolam or something.
You see the thing is that it wasn't so much the specific compound, it was IDENTIFYING that the a5b1y2 subtype is responsible for all of the positive effects of alcohol.
Oh, and MOST of the negative effects (all the emotional and behavioral ones) are mediated by the a1b1y2 subtype.
AlsoTapered
Bluelighter
It neither helps nor hinders. The fact I disclosed a compound that ISN'T covered by any of their patents (as far as I know) just shows that it's a very narrow patent.
The fact that I disclosed the fact that both a 1,4-benzodiazepine AND a 1,5-benzodiazepine emulate alcohol much more accurately is of manifest benefit to them, I would think.
What I DIDN'T disclose was the single compound that binds at both the a5b1y2 AND a5b2y2 subunits. Maybe they have solved this problem, maybe they have not. Maybe they aren't using a benzodiazepine scaffold for their newer compounds? I don't know - but their is nothing harmful to them.
I'm sure I heard similar. Starting using benzo in the early research, but didn't use it for the final product.
I saw a video of Nutt holding a jar containing his finished Alcarelle. Of course, it could just be water
as it was a clear liquid.
AlsoTapered
Bluelighter
I'm sure I heard similar. Starting using benzo in the early research, but didn't use it for the final product.
I saw a video of Nutt holding a jar containing his finished Alcarelle. Of course, it could just be water
The truth of the matter is that ANY drug that, by whatever means, results in an increased flow of chloride ions into neurons (resulting in postsynaptic hyperpolarization and CNS depression) will produce tolerance and dependence.
Yes, one can try partial agonists like pagoclone or novel ligands like kavain but at the end of the day, the neurons adjust and their is nothing you can do about it.
Now their ARE other targets. Possibly the orexin receptors and possibly the glycine or glutamate receptors, but what little we know of those targets is that tolerance and dependence still occur.
But lets not forget that the company is actually CALLED GABA Labs.
I would not be even SLIGHTLY surprised that it's simply a variant of pyeyzolam that at least would keep non-technical shareholders happy. We dissolved 1 gram of pywyzolam into 1l of dH2O and 25-35mL of the solution will reliably render anyone drinking the solution 'pseudodrunk'.
BUT as I said, pyeyzolam has a VERY steep dose-response curve. Upto about 20mg it does nothing but at 30mg people are '2 bottles of wine' drunk. So it would keep non-technical shareholders happy.
As I said, we went on to discover that a 1,5-benzodiazepine simulates lower doses of alcohol so our intermediate answer was to simply mix the 1,4-benzodiazpeine with the 1,5-benzodiazepine. But then we developed a single compound that binds to both receptor subtypes.
MAYBE GABA labs have done that. But it took some REALLY difficult chemistry to isolate that single compound. It took years... but I don't see ANY new patents which makes me think it's pyeyzolam.