RCs Bromazolam

[Fertile]

By the time samples of pyrazolam had been produced, it was evident that some people would imbibe 'heroic' doses. Being as it was the first RC benzo, it was key to produce one that was as safe as possible. Animal tests showed no toxicity even up to very large doses... so it wasn't blindly chosen. It was as much as it was realistic for someone to obtain in a single order.

Lets face it, IF it was toxic, a great way to end up as a headline is by people dying and their only being 1 producer. I do not recommend it. It wasn't fun. But I was quite confident it would be OK.

But when nitrazolam began to appear, I realised that people who may have developed a huge benzodiazepine habit MIGHT end up being poisoned by it. I mean, even though nitrazepam (Mogadon) was the very first benzo aimed at treating insomnia, replacements turned up quite quickly and none of those later compounds were nitrobenzodiazepines. Without admitting fault, replacements were being sought.

 

[negrogesic]

It certainly should NOT be yellow. It's a nice clean solid with a clear melting point. It's very likely that pyrazolam like bromazepam may cause stomach cramps in rare cases. It modulates gastric acid release.

100mg was tested after a lot of animal models to prove it's inherent non-toxic properties. You may be aware that the nitrobenzodiazepines are much more toxic in overdose. Nobody has ever confirmed just why that is, but it's worth noting that the majority of fatal intentional poisonings in nations that prescribe nitrobenzodiazepines ARE by nitrobenzodiazepines alone. Sweden being a good example.

Even at 100mg only a small amount of retrograde amnesia and sedation were noted. I do not recommend it, but unless we tested it, we would have no idea of how safe the compound was.

This is my sample of pyrazolam. It is of chinese origin and GCMS tested as containing pyrazolam only (independently, not the vendor's GCMS). Ugly looking stuff (though note that I left it in bag for a while so it might have suffered a bit, yet it was always ugly looking). Inert compounds were not tested for only actives so purity is unknown, but it is very clearly active at low doses. I agree it isn't sedating at low doses but I found it to be quite sedating at high doses.

 

[negrogesic]

Yeah same issue for me, except I disagree when you say "without altering one's personality." It screws with my mood a little too much. I also feel sad or something close to it on Pyrazolam. "Despair" seems too heavy of a term; it's more like a feeling of deep ennui riding just underneath the surface.

I suppose I should have said, without altering one's personality as much as other benzos. I'm also referring moreso one's outward personality (ie., how you seem/appear to others). Disinhibited benzos like etizolam and alprazolam make me outwardly act quite different than normal, a more disinhibited, egomaniacal, exaggerated version of myself, yet also empty, which leads to risk taking behaviors. They also increase aggression. If I have a significant amount of etizolam in my system, God have mercy on you if you cut me off with your car, but with pyrazolam I'm not likely to react

Pyrazolam is good for say a job interview, when you need to be yourself and present, but also want some significant anxiolysis. Only problem is, it will be a sad drive home.

 

[Fertile]

This is my sample of pyrazolam. It is of chinese origin and GCMS tested as containing pyrazolam only (independently, not the vendor's GCMS). Ugly looking stuff (though note that I left it in bag for a while so it might have suffered a bit, yet it was always ugly looking). Inert compounds were not tested for only actives so purity is unknown, but it is very clearly active at low doses. I agree it isn't sedating at low doses but I found it to be quite sedating at high doses.

Warning - that sample may WELL contain the acetyl hydrazide intermediate. Their was another impurity we didn't identify BUT it took 17 attempts to find the right conditions (solvent, temperature, time) for the amide --> thioamide step. Above looks like it has the thioamide in it - hence the colour.

Unless you can wash it yourself (and the intermediate will not contain a basic nitrogen so will be removed using a B/A wash, I would not touch it.

I forgot to mention that we ALSO chose a compound we knew to be HARD to make (from experience). That is why, i presume, nobody ever made other analogues that had a pendent pyridine. The Chinese do NOT know how to make it, evidently. But that they didn't bother to clean... lazy.

 

[unodelacosa]

Only problem is, it will be a sad drive home.

Title of my memoirs

But that's interesting – I'm aware of the phenomenon whereby disinhibiting GABA-ergics promote rapid, unchecked aggression and/or anger. It happens to me when I have more than two drinks, so I cap myself. You know: "know thy limit", and all…

Warning - that sample may WELL contain the acetyl hydrazide intermediate.

It's possible. Hey, @negrogesic – did it arrive with this discoloration or was that acquired over a spell of time whilst kept only in a simple plastic bag? I'm thinking it's degradation based on what I've encountered, but if it arrived like this, all bets are off, ya know?

Unless you can wash it yourself (and the intermediate will not contain a basic nitrogen so will be removed using a B/A wash, I would not touch it.

Are you saying it needs a full, acid-base extraction/wash, or would a 10% NaOH wash suffice? Rinse it w/dH₂O and vacuum filter it dry, something like that?

 

[Fertile]

You must have noted that triazolo benzodiazepines have a basic nitrogen (between the 1 & 3b carbons). Alprazolam hydrochloride is what is in Xanax.

None of the intermediate can form addition salts. This will make it MUCH less soluble in non-polar solvents. I mean, it's actually reasonably soluble in water (70g/L) so fractional crystalization might be better.

Just dissolve in hot water (anything that won't dissolve is thrown away) and then cooled. Keep an eye on formation of crystals as water slowly cools. Keep getting crops of crystals and while they aren't white, dry, weigh & discard. Then when it IS white crystals, keep on cooling until your water JUST begins to freeze (it will be below 0C). And collect all of the crystals. Dry and weigh. If you put in 70g, how much crystalized out?

Obvious at scale, if you only get 60g back (55g of crap + 15g of product) then no problem - add 60g (so you have a total of 70g) and do it again. THIS is an example of mechanical losses and how the design of scaled synthesis can be of increased yield.

A huge shame that pynazolam (designed to test if nitrobenzodiazpines are serotonin releasers - they ARE) and pyeyzolam, the alcohol mimic. Thus:

https://ibb.co/qd3NNZj

See how we found a scaffold and then tried different 8-substituents to see how diverse the subjects effects could be.

As you may know, triazolobenzodiazepines with 8-nitro moieties are never seen simply because the triazolo ring precludes a1 (a hypnotic GABAb subtype) affinity so it was to test OTHER activity. And what a surprise - it was a potent serotonin releaser. VERY euphoric. VERY much like methaqualone (Quāālude) but instead of needing 300mg, 10mg was enough.

Looking at the work of Professor James A. Cook as Minneapolis State University School of Medicines, and 8-ethynyl would produce a compound that was a5 selective. It really did a good job of emulating ethanol. All of the positive effects, none of the negative (many of them a1 mediated so possibly a simple 3-ring benzo with a 7-ethynyl would be even more accurate... but a lot of alcohol's negative effects are a1 selective - so we left it out. The problem was that 10mg did nothing... 20mg and it was like you had drunk 2 bottles of wine. It could not emulate 2-glasses of beer 'tipsy. so I came up with pyzolam:

1

Image 1 hosted in ImgBB

ibb.co

Because 1,4-benzos are B1 selective whereas 1,5-benzos are B2/B3 selective and so this was a5b2 & a5b2 selective. Of course, this would theoretically mean that 2 novel compounds would have to go through all of the toxicity tests..... almost doubling development costs.... so what I needed to do was to produce a dimer - a compound that contains a pyrazolam-pyzolam bridge.... which is done.

 

[JackARoe]

No lingering effects so its half live is not absurd like Diazepam, Diclazepam and a few others.

So far it seems a reasonable Benzo. Maybe a bit better then Alprazolam as that one made me sad.

Tripsit has bromazolam look even shorter than etizolam. Not sure how accurate that is. I can say if I take 2 mgs of etizolam I can feel it the next day. I think the secondary metabolites work on me since I am sort of naive.

Been looking into Bromazolam. Not sure if this is Reddit rumors and I am sure there is a way to look it up but the US placed a bunch of benzo's in an emergency schedule 1 including etizolam. (??) Yet some legal expert was saying you can't make an analog of a substance that is not in schedule 1 into schedule 1. Anyway hope it is a rumor only if for the people that are in as pickle with these substances.

 

[PtahTek]

Tripsit has bromazolam look even shorter than etizolam.

I do not think so. I have read and reread info on bromazolam and find it holds one "down" at 2mg or more for a full day or two. I have experienced this. It may have to do with the muscle relaxing and mild pain relieving properties, IDK but unless I wanna get "lost" I feel no need to dose compulsively compared to smaller doses. Just dont need it or even feel that I do.
I didnt get much on etiz but maybe I didnt try hard enough surely the source is legit.
I would put 1-2 mg of bromazolam equal to or longer than diazepam half-life or "feel". Fuck taking 10mg brmzlm lol I would be a fool for sure or knocked tf out or both.
Just my experience(s)
Peace

 

[JackARoe]

I didnt get much on etiz but maybe I didnt try hard enough surely the source is legit.

Thanks Lil, I was wondering what you thought of etizolam. A lot of people like it and a lot of others did not compared to other benzo's.

Was wondering if a person took a light dose of bromazolam, like at 1 mgs if it would wear off within 10 hours. A heavy dose of any benzo lingers including etizolam for me. But that may be to not taking them much.

Etizolam has gotten so hard to get, use to be all over. I liked it because it was not too strong.

 

[PtahTek]

bromazolam, like at 1 mgs if it would wear off within 10 hours.

Depends on tolerance, of course. But after several months 1mg will still make me wanna close my eyes about 15 minutes in. Can fight this with movement but if one gives in I find I awake after only 5 mins or so and am fine just relaxed as a mf. Usually I get up and start cooking something. lol
10 hrs? Yeah. IMO/E you will be fine.

 

[JackARoe]

10 hrs? Yeah. IMO/E you will be fine.

Thanks, I know you can take it at sub milligram dosages. May start with .5 if I do end up trying it

I guess if there were any truth to the scheduling of RC benzo rumor in the US we would have heard it by now? Seems to be talked about on Reddit. But if it is true people that utilize these things way more than me should know.

Oh Lordie, going to head over to your Bible verse thread for inspiration Lil.

 

[PtahTek]

I guess if there were any truth to the scheduling of RC benzo rumor in the US we would have heard it by now?

A lot of it I think is in the import/export of these chemicals.
Once ya have it it was found onda sidewalk for anyone knows.
Bromazolam is being scrutinized in PA as it is particularly resistant to narcan and wouldn't surprise me if it is next on the schedule.

US: Bromazolam Prevalence Surgining Across the United States​

NPS Discovery would like to notify you about new information regarding the new benzodiazepine Bromazolam. Identifications for this benzodiazepine are increasing based on our data from comprehensive toxicology testing of authentic biological samples, driven in part by increasing detections alongside the synthetic opioid fentanyl. Bromazolam has been identified in more than 250 forensic cases originating from various states and regions across the United States. It should be noted that bromazolam is not widely incorporated into forensic testing workflows and could be missed during standard toxicological investigations. This new Public Alert details our results and recommendations to help our collaborative communities combat this new drug.

Source

There have been lots demonizing this substance but for some reason it seems to be getting buried in searches now.
Be safe is all, OK?
Peace

 

[JackARoe]

Yes the importing and exporting I knew about from last year. Read last night on Reddit that flualprazolam, flubromazolam, clonazolam, etizolam, and a few others were scheduled by the D EA. That would affect a lot of people IF that is true. Like I said there were some legal experts saying it does not make sense as you can't make an analog of a substance be schedule 1 if the original substance is not schedule 1.

I do remember when etizolam was demonized. The media tried to do that with kratom but it did not work. (Thank you Chuck Rosenberg for listening to the letters and backing off). The US has federal protection in small ways for now. (the AKA annoys me but they do get stuff done)

It is for sure easier to make a chemical illegal. I am not sure the US will ever make a natural product illegal again.

 

[emkee_reinvented]

Still, one exception I'd like to see is flunitrazolam, the triazole- analogue of rohypnol.

It was imo a dud. Nothing special actually a functional Benzo. 0.5 mg didn't knock me out like I presumed.

Flunitrazepam wasn't much better in terms of expectancy. Just a average Benzo. They are all more or less the same, but its due to Etizolam, Temazepam, Clobazam/ Pyrazolam and my need for sleep after stimulants that drove me to them.

Those four I mentioned all seem better then the rest. Etizolam is perfect all purpose. temazepam euphoric AF. And Clobazam and Pyrazolam I really like. They do what needs to be done without the annoying Benzo side effects. Clobazam when taken in the period before an epileptic attack occurs is heavenly.

How would Nimetazepam be, I am really curious about that one. They actually have an drug market for that one in East-Asia. It again shows that LAM is not persee better then PAM.

 

[emkee_reinvented]

A lot of it I think is in the import/export of these chemicals.
Once ya have it it was found onda sidewalk for anyone knows.
Bromazolam is being scrutinized in PA as it is particularly resistant to narcan and wouldn't surprise me if it is next on the schedule.

Source

There have been lots demonizing this substance but for some reason it seems to be getting buried in searches now.
Be safe is all, OK?
Peace

Narcan is Naloxone right, the antidote for an Opiod OD.

Are you maybe reffering to Flumazenil, the antidote for Benzo OD's?

 

[emkee_reinvented]

Tripsit has bromazolam look even shorter than etizolam. Not sure how accurate that is. I can say if I take 2 mgs of etizolam I can feel it the next day. I think the secondary metabolites work on me since I am sort of naive.

Been looking into Bromazolam. Not sure if this is Reddit rumors and I am sure there is a way to look it up but the US placed a bunch of benzo's in an emergency schedule 1 including etizolam. (??) Yet some legal expert was saying you can't make an analog of a substance that is not in schedule 1 into schedule 1. Anyway hope it is a rumor only if for the people that are in as pickle with these substances.

Couldn't resist buying some of this Bromazolam ( Again! According to one of my older posts its not the fisrt time ).
One of the listed side effects is getting a lot more Bro's.

As soon as I have taken one, not one of my new bro's you pervert's, I´ll give an first impression.

 

[PtahTek]

Narcan is Naloxone right, the antidote for an Opiod OD.

It is.
If I read rightly they are coming up with an updated version to combat these newer compounds that are either resistent to narcan or ingredients that make it ineffective (like benzos and other adulterants).

 

[Fertile]

Good - naloxone has just about the same Ki as fentanyl for the mu receptor so it's been getting more and more difficult to bring people back. The N-allyl homologue of nalmefene is likely a good option. Very fast onset and call me dumb, but it's of a class of opioid where the QSAR is best understood. There are newer classes of antagonist, but not well characterised (by comparison).

 

[JackARoe]

I do not think so. I have read and reread info on bromazolam and find it holds one "down" at 2mg or more for a full day or two. I have experienced this. It may have to do with the muscle relaxing and mild pain relieving properties, IDK but unless I wanna get "lost" I feel no need to dose compulsively compared to smaller doses.

I figured with all my questions over the last year or two that I owe at least my own opinion on this. Actually since I only tried once I don't have an opinion yet. I think. Just some thoughts. All of this considered by your notes Lil.

I finally broke out my 2 mgs pills. Crushed one, split it into two piles and took the smaller half. If I were to estimate .7 mgs? I needed to start light. What struck me is within 20 minutes I could feel all my muscles slink back and relax even before the mild benzo effect took effect. It is always sound that changes for me when a benzo hits. Becomes a little muffled. In fact half the time I took etizolam that is all I could feel to tell it is working until I lay back and fall asleep. But the muscle relaxation was noticable with the bromaz. As I was watching TV I closed my eyes for a second and fell asleep for two hours. Woke up and went to bed. Slept good. No after effects today but the dose was light.

Balance was for sure affected much more than anything else. That is one note I can make. Not much, but if the dose gets larger I can see some stumbling around similar to alcohol. I think that alone makes driving on it sort of dangerous. (and hurting backs Lil, I see it now)

I think a lot of people said it. Seems as strong as etizolam mg for mg but different. I would imagine if someone needs their muscles calmed this is a good med. I saw that right away. I think it would make a good prescription med. I will give this another shot in a week or two at 1 -1.5 mgs.

 

[tactics625]

If flurazolam is the same as Flu-Alprazolam its allready being produced. I didn't like it less then Alprazolam, duration is longer aswell as the onset.

But my favorit benzo's are Etizolam an Clonazolam. Temazepam and Lorazepam when I would have had the oppurtunity of going the legal route.

Loved to try BromazePam though

Ketamine has been studied for neuro plasticity with great results! It also helps with anxiety and depression. I've been on the ketamine program for around three months and it's working. This is all legal and you can google a program.