I push this old thread cause I think it's quite interesting AND I have info and anecdotal experience with some herbs cited here,
Also, maybe
@AutoTripper could benefit from this post and probably he has not seen it (?).
I'm personally studying and bio-assaying a lot of different herbs for the treatment (and eventually reversing, if I could) diabetes type 1.
Is not clear AT ALL how the triggers work for such autoimmune reaction such as the immune system fucking up beta cells, there's quite a lot of hypothesis, in my case was probably a vaccine (MMR vaccine) because I got diabetes type 1 diagnose only a few weeks after that vaccination and I have no family members with this disease which is typically (supposedly..) normally "gene related". There's serious medical suspicion about that vaccine and also related with diabetes type 1 (mumps caused a notable rise diabetes type 1 when it was epidemic)
I've found that using artemisia annua GREATLY IMPROVED my sugar levels. I started using it when I got covid. Couldn't realize that it was doing anything when I got covid because normally during viral infections the sugar rise so much. But... after the covid infection, I stopped using artemisia and found that something odd had happent, my sugar levels were almost perfect, for days in a row, and when I got bad numbers it wasn't very bad... which is not typical for me, specially while being under a lot of stress which is happening nowadays.
I even thought that covid had done something GOOD to my body, because I couldn't understand why such an amazing improvement had happent...
Well, then it started going worse (but not as bad as typical, just a bit worse) after some weeks. Then I took the decision of taking artemisia annua again because I found during covid that it's great for improving dream lucidity and I even had 2 amazing lucid dreams during the covid period while using AAnnua.
So then, I started using again by night and my number improved again to PERFECT levels. I don't think it's a coincidence at all..
I've found very interesting papers about this:
Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health problem. Studies on T2DM prevention and treatment mostly focus on...
www.frontiersin.org
FDA-approved artemisinins, which have been used for decades to treat malaria, transform glucagon-producing alpha cells in the pancreas into insulin producing cells, researchers report.
www.sciencedaily.com
This one is the most important and I think it's quite amazing, to be honest:
Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine. One promising approach is transdifferentiation of developmentally related pancreatic cell types, including...
pubmed.ncbi.nlm.nih.gov
It's explained in a more straightforward way here:
For years, science has sought to achieve a very specific goal in diabetes research: find a way to replace diseased beta cells with functioning ones, thus reversing diabetes
www.informationaboutdiabetes.com
This is also pretty interesting:
Type 1 diabetes (T1D) is an autoimmune disease characterized by the immune-mediated destruction of insulin-producing β cells. Recent studies showed that in addition to malaria, artemisinin and its derivative, artesunate (AS), could alleviate several autoimmune diseases. However, whether AS has a...
pubmed.ncbi.nlm.nih.gov
So basically artemisinin could affect alpha cells in pancreas (which are over-represented in diabetic type 1 patients and are bad for us cause they produce glucagon that causes hyperglycemia..) and turning them into beta-like cells which produce insulin! wow, it's honestly fucking amazing.
I post this here not only because some similar stuff could happen with syrian rue's harmine, which can multiplicate beta cells. Some people from Mount Sinai research found among 100k plants that harmine was able to do that...
New York, NY ( February 12, 2020)— Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells—the cells in the pancreas that produce...
www.jdrf.org
A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a major contributor to all common forms of diabetes. This is the underlying premise for attempts to replace beta cells in people with diabetes by pancreas ...
www.ncbi.nlm.nih.gov
So then, basically we could make a triple combo of harmine, artemisinin and some plant extract that could be a TGF beta inhibitor to make an amazing antidiabetic drug combo... it's not impossible, it's not even difficult..
This present study revealed that CME of Fagonia cretica and Argemone mexicana significantly inhibit TGF beta mediated signaling cascade by downregulating the gene expression fold change > 1 of TGFβR 1, 2 & 3 and receptor associated complex protein SMAD3 as compared to control.
pubmed.ncbi.nlm.nih.gov
I would bio-assay myself, I need to learn how to create an harmine extraction cause I know it's not very difficult to extract harmine/harmaline extract from syrian rue, but I think it's a bit more complicated to separate each..
Any advice from bio-chemists and weekend Walter Whites?
I can swear that artemisia annua does something very positive on my sugar levels, as well as kratom, that allows me to inject less insulin than normal.