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What is wrong with the MDMA available today? - v2

I do take psychedelics often, but never took any psychedelic before attempting to roll. Though I've tried many times to augment MehDMA with primarily 2C-B about 2-5 h after dropping. When I'm on MehDMA, 2C-B doesn't do shit. Others have described similar experiences. This surely points at that something in the MehDMA binds to receptors 2C-B normally hit. And I'll second F.U.B.A.R. in that I could very easily differentiate 75-80 mg of magic MDMA from any of the at least 10 different batches of MehDMA I've tried - even if I took 150-200 mg of that.
 
I wish it were that simple.

Unfortunately, MehDMA cannot be made Magic simply by increasing the dose (god knows I've tried). It just doesn't work like that.


Conversely, a low dose of good MDMA doesn't turn it into MehDMA - its still obviously good and displays NONE of the MehDMA 'symptoms'.

They are totally different animals...

Yeah, I recall situations like @Hilopsilo talked about where there were not enough pills to go around, and people would end up just taking half a pill instead of a whole pill. This was back in the days when a single pill was 120 mg or so, or even less. Even that half pill would be plenty and you would feel fantastic, and would have a great "light roll" going on. Just a very different vibe/flavor to the experience.
 
I do take psychedelics often, but never took any psychedelic before attempting to roll. Though I've tried many times to augment MehDMA with primarily 2C-B about 2-5 h after dropping. When I'm on MehDMA, 2C-B doesn't do shit. Others have described similar experiences. This surely points at that something in the MehDMA binds to receptors 2C-B normally hit. And I'll second F.U.B.A.R. in that I could very easily differentiate 75-80 mg of magic MDMA from any of the at least 10 different batches of MehDMA I've tried - even if I took 150-200 mg of that.

Yeah, taking 2CB after MehDMA does not work. I have very bad reactions to that like migraines. But, taking it first makes the MehDMA better. Go figure.
 
That last paragraph I think sometimes might be the answer to this. I notice that those of us who seem to still roll good also very often take psychedelics in conjunction. I don’t always, and when I don’t I still have a great experience but I still prefer my rolls with LSD or some other psychedelic mixed in.

I’d say I only roll without a psychedelic once a year, maybe once every other year. It’s usually a time where a psychedelic just isn’t fitting with the setting, but like I said even those times I still get everything I expect from it so I don’t often mention it on here.

I’ve wondered though maybe there is a neuroprotective component or possibly neurogenesis after the fact. I also use psychedelics a fair amount outside of my MDMA use too.

I’d like to hear from individuals here who use psychedelics fairly frequently but still don’t roll properly..


As for the experience, that all sounds about right. I’ve found 80mg doses are only “good” on the purest of product. That type of crystal that is so clear when you set it next to other apparently clear crystals they shine in comparison. Especially if there was an expectation amongst some of the crew to be getting doses bigger than initially expected.

That said, I’ve liked hearing the stories of you and your crew. I’ve never had a crew quite like that but wish I did. My crew is much more eclectic in the drug preferences, so it’s rare we all get down on some MDMA like that. How ya’ll shared it even when it meant smaller doses is exactly what the scene is about, my hat off to you sir.

-GC

It's contagious!!! We didn't have enough because no more than 4 ppl had committed to rolling prior to arriving. Also, karma bit me in the ass making that snarky post about ket; the K was missing from our order and a couple friends went full rave-bridezillas, and I had to arrange exchanging the extra M we got w/ the random other guy who got our K, luckily going to the same show...

Theres a few friends who M doesn't work for well but still take it anyways that I whole heartedly believe need to up their dose by like ~50mg just judging by what they complain about & I know they weigh enough to up the dose. Outlier being ~65kg person that always needs ~200mg. Always those friends I look in eye and know for sure budz had 2 caps tonight.

As everyone's pointed out, ya the dose increase on the MehDMA doesn't exactly pay off anecdotally (though some of these scenarios involve redosing in reaction to mehdma, which is a whole other variable). In my experience there is a lot in common between MehDMA and low dose rolls. i.e. the low energy sleepy sleepy roll, just observing myself & others, totally a low dose thing Meh or not. They both end up a firework that didn't go off, even if it was a little pretty anyways. Agree to disagree, or maybe I've never had the mehDMA and only lowdoses caused by byproducts:shrug: I dont feel i've had enough controlled experience to say one way or another confidently.

I think I may start suggesting to friends to consider calc'ing their dose off bodyweight if they feel underwhelmed taking 100mg. I've seen some figures thrown around, kg+50,=mg or kg*1.7=mg, soft capped at maybe ~200mg. Most suggested dose calculation I read put my dose right at 100-120mg, checks out in my experience. I've mentioned before, with lurv & respect, 1:1 correlation between my friends who are overweight & those who can't seem to roll without stomach issues/general discomfort, I feel uneasy about suggesting to increase their doses as their difficulties w/ the substance aren't limited to it not working hard enough like the others.

I'm convinced a good curry a few hours before taking drugs is the ideal:redneck: keep that stealth navel orange if u hit turbulence

The times where the roll was so good I actually almost freak out thinking I've moved onto the afterlife were on 4+ tabs of acid. That same M can't achieve that on its own for me.
 
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Great find.
I thought you might like that.
We were talking about P450 in @G_Chem's other thread, I think. This is the cytochrome inhibited by grapefruit as well. This could partially explain the potentiating properties of 2CB.
Also, it’s interesting what the article had to say about oxytocin, which IIRC was also something mentioned earlier in this thread.

Vis-à-vis cytochrome P450, to be fair, it affects a fairly large number of substances. However, not everyone exhibits cytochrome P450 the same. Some people seem to have it in abundance and their medication is very much affected by, for instance, grapefruit juice (or anything inhibiting this enzyme), while others don’t seem to be affected much by this phenomenon.

I find it interesting that many drugs are also potentiated by the user actively keeping a high renal pH, this includes most monoamines like MDMA, 2C-B, tryptamines, phenethylamines (PEAs), alpha-methylated PEAs… here’s a funny way to call methamphetamine: α,n-dimethylphenethylamine. Or going on that logic you could call MDMA: 3,4-methylenedioxy-α,n-dimethylphenethylamine. But I digress.

Fun fact: it’s bad to combine MDMA and caffeine (source 1, source 2)
 
I thought you might like that.

Also, it’s interesting what the article had to say about oxytocin, which IIRC was also something mentioned earlier in this thread.

Vis-à-vis cytochrome P450, to be fair, it affects a fairly large number of substances. However, not everyone exhibits cytochrome P450 the same. Some people seem to have it in abundance and their medication is very much affected by, for instance, grapefruit juice (or anything inhibiting this enzyme), while others don’t seem to be affected much by this phenomenon.

I find it interesting that many drugs are also potentiated by the user actively keeping a high renal pH, this includes most monoamines like MDMA, 2C-B, tryptamines, phenethylamines (PEAs), alpha-methylated PEAs… here’s a funny way to call methamphetamine: α,n-dimethylphenethylamine. Or going on that logic you could call MDMA: 3,4-methylenedioxy-α,n-dimethylphenethylamine. But I digress.

Fun fact: it’s bad to combine MDMA and caffeine (source 1, source 2)
Caffeine might be in drinks like lucozade which your supposed to drink while taking mdma
 
Fun fact: it’s bad to combine MDMA and caffeine (source 1, source 2)

I assume the vast majority of people consume caffeine with MDMA as it's so prevalent.

Perhaps it can cause complications in some individuals, but some individuals also die from just MDMA alone.


I don't think it's fair to say the combination is 'bad' per se.


(Lucozade definitely DOES contain caffeine)
 
I assume the vast majority of people consume caffeine with MDMA as it's so prevalent.

Perhaps it can cause complications in some individuals, but some individuals also die from just MDMA alone.


I don't think it's fair to say the combination is 'bad' per se.


(Lucozade definitely DOES contain caffeine)
Hmm well best not take too much
 
Perhaps it can cause complications in some individuals, but some individuals also die from just MDMA alone.
I don't think it's fair to say the combination is 'bad' per se.

No, it’s definitely bad for you, per se. Just how bad compared to MDMA alone? I’m not certain. Not like do it once and you’re permafried brainfucked or anything, and let’s keep in mind ethyl alcohol is also neurotoxic and some brain cells die every time a person drinks… So just keep things in perspective, but also make no mistake about it: caffeine w/MDMA = bad for the body. I’m not even saying don’t do it; I‘ve done it probably four or five dozen times knowingly during my lifetime, and considering how ubiquitous caffeine is as a cut, I can only imagine how many times I’ve ingested this combination.

Regardless knowledge is power. Check out the abstract from the article (bold mine):

Concomitant consumption of caffeine with recreational psychostimulant drugs of abuse can provoke severe acute adverse reactions in addition to longer term consequences. The mechanisms by which caffeine increases the toxicity of psychostimulants include changes in body temperature regulation, cardiotoxicity and lowering of the seizure threshold.

Caffeine also influences the stimulatory, discriminative and reinforcing effects of psychostimulant drugs. In this review, we consider our current understanding of such caffeine-related drug interactions, placing a particular emphasis on an adverse interaction between caffeine and the substituted amphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’), which has been most recently described and characterized. Co-administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality.

In addition, co-administration of caffeine enhances the long-term serotonergic neurotoxicity induced by MDMA
. Observations to date support an interactive model of drug-induced toxicity comprising MDMA-related enhancement of dopamine release coupled to a caffeine-mediated antagonism of adenosine receptors in addition to inhibition of PDE.

These experiments are reviewed together with reports of caffeine-related drug interactions with cocaine, d-amphetamine and ephedrine where similar mechanisms are implicated. Understanding the underlying mechanisms will guide appropriate intervention strategies for the management of severe reactions and potential for increased drug-related toxicity, resulting from concomitant caffeine consumption.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492978/
 
Wanted to share this here too..


Rather interesting article that looks at MDMA’s hormonal release in correlation with subjective effects. Notice how DHEA correlated with euphoria. DHEA drops steadily as we age.

They also have Cortisol correlating with drug liking which I think purely comes down to the fact the harder we rush the better we know the roll will be once it peaks.

This has got me wanting to try DHEA supplementation before a roll here soon to see what happens.

-GC
 
Yes, it has, but I've seen very few (if any) comments that go right at that specific detail.

"It's not the same product."
"No, it's you."

And that's about it. How about "MDA works for me. 5-APB works for me. MDMA, not since whenever." That would be a less fuzzy comment less likely to be dismissed with "It's you."
Not true, you just haven't been following for long enough if you think so. There was a good bit about what worked, what didn't, when stuff last worked or last didn't, a couple of years ago, if not since. There's been plenty of detailed comments in this vein.

Wouldn't that be a neat & tidy bow to wrap this all up with? :rofl: The MehDMA is really just a lower MDMA:byproducts ratio so your 100mg ends up say, 80mg, and theres no simple or easy way to suss that out... This doesn't address the anecdotes about futile dose increases on the supposed MehDMA, amongst other things. But what I mean to say is, low dose MDMA seems to display a lot of the MehDMA symptoms, as so many have described it since the dawn of time "I just didn't quite roll".

Having taken MDMA on its own a couple times since I've tried paying more attention, might be obvious, but I feel I can definitively say LSD or any psych potentiates the crap out of this stuff, no questions asked. Most of my fellow crew candyflippers seem to agree on this. Kinda abstract, but when on psychedelics I feel there is a sort of lust for "tension breaking" events/moments or sounds, and w/ MDMA & really loud punchy tunes, you're just getting fed that repeatedly & its just electric.
Good to see you around again, Hilopsilo.

1) I've never felt patently bad on too low a dose of MDMA as I have on MehDMA. Furthermore, most of my MehDMA experiences have been 120-125mg, some of them 140-160mg. Let's say there's a 60:40 ratio of MDMA:byproducts at 120mg - that means I'd be getting 72mg of MDMA. I've taken 75mg doses of MDMA orally and while it's not strong, per se, it's still a good time; heart opening, pleasurable, lovey, etc.

2) I haven't flipped too many times, and besides 2.5 years ago, haven't flipped in maybe 5-6 years, so I don't have a ton of experience or knowledge of psychedelics potentiating MDMA. However, I have taken MehDMA twice after low to medium doses of psychedelics and both times it's flat out ruined what was, before the MehDMA kicked in, an amazing time. Just flat out went from having an amazing time at a great party to feeling totally lousy and slinking off into a corner by myself. Since I first experienced this, I've felt that using whateverDMA after a psychedelic is a great way to tell if it's good or not. Though, if we're dealing with multiple causes of MehDMA, that's not necessarily the case.
 
Wanted to share this here too..


Rather interesting article that looks at MDMA’s hormonal release in correlation with subjective effects. Notice how DHEA correlated with euphoria. DHEA drops steadily as we age.

They also have Cortisol correlating with drug liking which I think purely comes down to the fact the harder we rush the better we know the roll will be once it peaks.

This has got me wanting to try DHEA supplementation before a roll here soon to see what happens.

-GC

I think indigo was trying this a few years ago...?
 
Right, so I wrote this:

Yes, it has, but I've seen very few (if any) comments that go right at that specific detail.

"It's not the same product."
"No, it's you."

And that's about it. How about "MDA works for me. 5-APB works for me. MDMA, not since whenever." That would be a less fuzzy comment less likely to be dismissed with "It's you."

Not true, you just haven't been following for long enough if you think so. There was a good bit about what worked, what didn't, when stuff last worked or last didn't, a couple of years ago, if not since. There's been plenty of detailed comments in this vein.

We're at 6 years and 381 pages of discussion on this.

Differential experience across substances by one person has a lot of value. That's one brain and one set of neuroreceptors and -transmitter levels. One person who has very different experiences with two things that should do more or less the same thing. That's interesting. Is it the person or is it the substance?

I care a whole lot less about when MDMA "stopped working" than I do about whether or not a person reporting MehDMA also reports on whether or not another similar substance is still working for them. I have not seen a lot of that -- some, but certainly not a lot. I've read the entirety of these threads over years, so sorry if I forgot a helpful report of yours.

But the thread continues to generate a lot of posts like
- MDMA sucks today!
- No, it's you!
- Contamination! Test your shit!
- Labs can't detect shit! OMFG! Crooks!
and that seems to me like a rathole. Or like going in circles.

I'd like to think that zeroing in the responses within one individual to various serotonergic drugs would help resolve, in many minds whether or not current MDMA or an individual's specifics is the reason for most of the disappointed reports. Your receptors are fried or they ain't. You got good MDMA or you didn't. If you report a disappointing time, but you didn't reagent-test it, and you ate a pizza 15 min before dropping, and your friends had shitty times too, and it was the first time for all of you, that report has just as many questions as it does answers. If you can still get the desired serotonin response from another substance, but not from MDMA anymore, and you once were able to, that report has some heft. (The question of different neuroreceptors notwithstanding, it's still much closer to a reasonable point of inquiry and has carved away some possible issues and ambiguity.)

Maybe that's a lot of words; maybe it gives a better idea of what I'm on about here. In any case, it's a very polite request to provide supporting information when possible, going forward, and by that I mean your responses to things like MDA, 5-APB, 5-MAPB, 6-APB, etc., also. (I hadn't been thinking of 2C-B, but indigoaura mentioned it in an interesting way here a couple posts ago, so yeah.)

But 6 years and 381 pages later, here we are. Consensus has been achieved? lol, no. So I'm suggesting/reminding that the response of one individual to different serotonergic compounds is interesting, especially when they vary, and I would like to see more. For example, "MDMA and 5-APB worked for me, and now 5-APB does and MDMA doesn't, oh but hey my buddy just pulled a 1998 stash out of his ass and wow I'm rolling balls again" is a good anecdotal post for this topic. Yeah, they exist in the discussion; yeah, I'd still like to see more of those posts.
 
Not true, you just haven't been following for long enough if you think so. There was a good bit about what worked, what didn't, when stuff last worked or last didn't, a couple of years ago, if not since. There's been plenty of detailed comments in this vein.


Good to see you around again, Hilopsilo.

1) I've never felt patently bad on too low a dose of MDMA as I have on MehDMA. Furthermore, most of my MehDMA experiences have been 120-125mg, some of them 140-160mg. Let's say there's a 60:40 ratio of MDMA:byproducts at 120mg - that means I'd be getting 72mg of MDMA. I've taken 75mg doses of MDMA orally and while it's not strong, per se, it's still a good time; heart opening, pleasurable, lovey, etc.

2) I haven't flipped too many times, and besides 2.5 years ago, haven't flipped in maybe 5-6 years, so I don't have a ton of experience or knowledge of psychedelics potentiating MDMA. However, I have taken MehDMA twice after low to medium doses of psychedelics and both times it's flat out ruined what was, before the MehDMA kicked in, an amazing time. Just flat out went from having an amazing time at a great party to feeling totally lousy and slinking off into a corner by myself. Since I first experienced this, I've felt that using whateverDMA after a psychedelic is a great way to tell if it's good or not. Though, if we're dealing with multiple causes of MehDMA, that's not necessarily the case.

Fair enough, though 72mg of any MDMA, for example, is not gonna give fully dilated pupils in most subjects i'd gander. Just pointing out that there is a ton of anecdotal crossover between low dose MDMA & "MehDMA". If I knowingly took 120mg MDMA, and the real dose was 72mg, I'd be screaming MehDMA.

In my "MehDMA" experiences, nothing has ever been patently bad about the symptoms, its more a crushing disappointment; dud firework. i.e. MDMA makes you paranoid, I believe less-than-sufficient dose will worsen this by not fully "breaking through". Leaving you in an edgy state where non-entactogenic thoughts will creep in, compacted by set & setting. All my "meh" experiences the after-hours of the high are even more difficult to tell apart from magic experiences; its the peak that isn't reached by a variety of markers that sum up to this huge letdown. So its possible my MDMA has been fine all along.

I understand there is an appreciation to be had for low dose MDMA, but no other drug relies as much on hitting a specific dose threshold. This "all or nothing" sentiment has been around since ever and I think for good reason. The times I've taken properly low dose MDMA (less than ~75mg), I find it actually made me kinda emo and antisocial, like very sentimental without feeling I can express it to anyone; no outlet (MDMA is 2 way street imo). Cannot confirm the quality of MDMA in those instances though. I see this in others as well, the ppl who dump a 50mg into their beer. Low dose MDMA can be dysphoric, this is not an uncommon opinion.

I think i coined MehDMA when in 2018 that smelly amber MDMA consistently across a large group didn't produce a good roll. The disappointment was palpable across a big group like that at such a time when it should have been good. But for all I know, that MDMA was 30% crap from synthesis (inert or not). I'm not trying to claim that term or anything, but I lose faith in it for my own purposes when ppl in my group just can't roll on stuff we know is good, or the result roughly fits into a low dose MDMA profile.

MehDMA is an abstraction we made up to describe an experience, theres no tangible way to know who's MDMA is screwed up in what way, who's getting lower dose than they think, and who just can't roll full stop. Respectfully, lumping all of this into MehDMA makes anecdotes about what MehDMA even is, very incoherent & somewhat dogmatic. Great works being done here but this thread often asserts far more than is known to be at all true.

Again respectfully, those of you who have had only MehDMA for many years on end now, taking far greater than your regular dose to compensate, what % chance do you set aside for that maybe you just can't roll? I think this is an important question to answer if we're being intellectually honest here.
 
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Right, so I wrote this:

Yes, it has, but I've seen very few (if any) comments that go right at that specific detail.

"It's not the same product."
"No, it's you."

And that's about it. How about "MDA works for me. 5-APB works for me. MDMA, not since whenever." That would be a less fuzzy comment less likely to be dismissed with "It's you."



We're at 6 years and 381 pages of discussion on this.

Differential experience across substances by one person has a lot of value. That's one brain and one set of neuroreceptors and -transmitter levels. One person who has very different experiences with two things that should do more or less the same thing. That's interesting. Is it the person or is it the substance?

I care a whole lot less about when MDMA "stopped working" than I do about whether or not a person reporting MehDMA also reports on whether or not another similar substance is still working for them. I have not seen a lot of that -- some, but certainly not a lot. I've read the entirety of these threads over years, so sorry if I forgot a helpful report of yours.

But the thread continues to generate a lot of posts like
- MDMA sucks today!
- No, it's you!
- Contamination! Test your shit!
- Labs can't detect shit! OMFG! Crooks!
and that seems to me like a rathole. Or like going in circles.

I'd like to think that zeroing in the responses within one individual to various serotonergic drugs would help resolve, in many minds whether or not current MDMA or an individual's specifics is the reason for most of the disappointed reports. Your receptors are fried or they ain't. You got good MDMA or you didn't. If you report a disappointing time, but you didn't reagent-test it, and you ate a pizza 15 min before dropping, and your friends had shitty times too, and it was the first time for all of you, that report has just as many questions as it does answers. If you can still get the desired serotonin response from another substance, but not from MDMA anymore, and you once were able to, that report has some heft. (The question of different neuroreceptors notwithstanding, it's still much closer to a reasonable point of inquiry and has carved away some possible issues and ambiguity.)

Maybe that's a lot of words; maybe it gives a better idea of what I'm on about here. In any case, it's a very polite request to provide supporting information when possible, going forward, and by that I mean your responses to things like MDA, 5-APB, 5-MAPB, 6-APB, etc., also. (I hadn't been thinking of 2C-B, but indigoaura mentioned it in an interesting way here a couple posts ago, so yeah.)

But 6 years and 381 pages later, here we are. Consensus has been achieved? lol, no. So I'm suggesting/reminding that the response of one individual to different serotonergic compounds is interesting, especially when they vary, and I would like to see more. For example, "MDMA and 5-APB worked for me, and now 5-APB does and MDMA doesn't, oh but hey my buddy just pulled a 1998 stash out of his ass and wow I'm rolling balls again" is a good anecdotal post for this topic. Yeah, they exist in the discussion; yeah, I'd still like to see more of those posts.

I don't think you've read my posts then. I've said many times that 6-apb is far superior to much of the MDMA I've acquired in the last decade.

I use 6-apb as a yardstick to gauge the MDMA I've taken.


When I drop I ask myself 3 questions:

1) Would I rather be on 6-apb now?

2) Do I feel a strong compulsion to redose?

3) Do I feel unsatisfied?


If the answers are all 'Yes', then I've hit the 'meh' again.


If the answers are all 'No', then I've got the real deal.
 
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