"The Holy Quadruplty"

[The Holy Quadruplty]

What effects do you get smoking weed while on opioids, and which opioid do you take with it/your favorite one to get high on?

 

[polyboss]

Mainly potentiation of the opioid, it makes it take off much faster and smoother. Yesterday I tried that 90/10 H to F mix and was very happy when I combined with a bit of weed. Luckily, I don't think weed induces more respiratory depression so I like this combo. I'm also on buprenorphine and I only ever need a bowl to get me faded.

 

[The Holy Quadruplty]

What are the effects? Do they go good together?

 

[Jabberwocky]

It's a good combo of you're not susceptible to anxiety. I used to like it before work, but these days it's too much stimulation for me.

It feels exactly like you would imagine.

 

[Electrum1]

I agree with Negentropic. Was fun when I was younger, but its just too much for me now to mix both during the day.

 

[falsifiedhypothesi]

For me, it would probably be a first class ticket on a panic attack, and i'm always riding second class when I smoke weed anyway

Still not worth it even if you're not prone to weed anxiety

 

[falsifiedhypothesi]

It's a pretty good combo and doesn't seem to add to cns depression.

What do you plan to do with this compendium of drug info?

 

[GetMeOutOfThisCRAP]

It is a pretty nice combination of effects, but if you don't have tolerance to marijuana or opioids it could be a bad time. Struggling breathing from the CNS effects of taking a bit too comfortable doses of opioids than your body can handle, combined with the crippling paranoia of marijuana being all anxiety in itself at times anyway.

Its not like there's any danger involved... I'm pretty sure every opiate addict has potentiated opiates with marijuana use to make the opiates feel "more." Don't get too used to that feeling though... It doesn't last too long and like most.. you may just be on opioids forever and forego the weed entirely. It is all the same. Morphine tablets/percocet/fent and marijuana is just all the same. The biggest issue here is that you will like the effects together and opiates sneak up on you. They really do hook one long before they are even able to notice their fate is sealed. Its a hell of a b*tch to get off them and stay off opiates/opioids. I don't recommend becoming familiar with opioid withdrawal.

SO much money. You will spend so much money and live in and out of withdrawals/"will it ever get better again without drugs?" Its just not worth going through. If you think marijuana is expensive (and it somewhat is actually), then just wait until you want to finance an opioid addiction lol.

 

[The Holy Quadruplty]

I never got anxiety or even noticable effects from caffeine as a kid that I can remember. I do nowadays though, but then again I only consume caffeine like once a week if that. The only reason I do is because it's in chocolate. Lol

 

[The Holy Quadruplty]

It's a pretty good combo and doesn't seem to add to cns depression.

What do you plan to do with this compendium of drug info?

Hopefully be able to keep it in my memory. Lol

 

[watermellon]

Smoking a bit of bud always used to help bring on the nod. Love it, one of my favorite combos. Usually a strong indica

 

[tweakerguy]

I never got anxiety or even noticable effects from caffeine as a kid that I can remember. I do nowadays though, but then again I only consume caffeine like once a week if that. The only reason I do is because it's in chocolate. Lol

That's because you're looking for the effects now and probably better at recognizing them, as opposed to when you're a kid, you're already jacked up on 3 bowls of fruity pebbles.

Some useless info.

 

[The Holy Quadruplty]

Why do they say Xanax isn't a GABAa agonist when the GABAa antagonist reverses it's effects, other websites say it is an agonist off GABA, and the swiss target predictor even says it does as well? It even says it binds to other GABA receptors.

 

[The Holy Quadruplty]

That's because you're looking for the effects now and probably better at recognizing them, as opposed to when you're a kid, you're already jacked up on 3 bowls of fruity pebbles.

Some useless info.

True, I still be getting geeked up off them fruity Peebles frfr I swear I had a bowl last night no lie!

 

[The Holy Quadruplty]

Yea weed definitely enhances an opioid high forsure. No mids though. Lol

 

[The Holy Quadruplty]

Can anyone link me to any studies on the effects of buprenorphine with xanax?

 

[LucidSDreamr]

Off the top of my head I'm pretty sure benzos are gaba modulators...
Not agonists like baclofen or lyrica.

 

[The Holy Quadruplty]

Off the top of my head I'm pretty sure benzos are gaba modulators...
Not agonists like baclofen or lyrica.

Not what I've read and saw, but I also heard that as well. I also heard lyrica doesn't bind to GABA at all just voltage gated calcium channels making more GABA essentially.

 

[The Holy Quadruplty]

Can caffeine after an opioid kill or lesson the effects of the opioid? Can it effect the opioid negatively at all taken afterwards?

 

[LucidSDreamr]

Not what I've read and saw, but I also heard that as well. I also heard lyrica doesn't bind to GABA at all just voltage gated calcium channels making more GABA essentially.

Pretty sure Wikipedia says they are modulators and not agonists.

I havnt dove deeper into the actual scientific papers on it though.

The neuroscience and pharmacology subforum probably has this same discussion or will be a better place to ask the question.