Sky God
Bluelighter
I never got much from it but i have a high opiate tolerance. I felt a small mood lift that wore off quickly. Who ever compared it to heroin never tried heroin
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OD Moderators: Keif’ Richards | negrogesic
Opioids Tianeptine Megathread v1
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- Start date
Sky God
Bluelighter
you can also rick serotonin syndrome because it has been prescribed as an anti depressant
Jabberwocky
Frumious Bandersnatch
I tried it at 12mg (therapeutic dose) and then 150mg oral. Both doses produced significant irritability leading to frustration and depression. 150mg had opioid effects however gave me some scary CEVs. Laying in bed I kept seeing an angry man repeatedly reaching for my throat trying to choke me. It was disturbing.
Tossed it after that with no desire to use it again.
Tossed it after that with no desire to use it again.
Tryptamite
Bluelighter
Where did you read that serotonin is an issue here?
I believe MOR is responsible for almost all the effects. I'm not even sure if the whole SSRA thing was ever much more than a theory.
Having said that there certainly is more than just MOR effects goin on there especially at supratherepeuric doses.
I'd love to know what oral tianeptine ba is compared to IV which I presume is 99-100%.
I thought it was very high but maybe not because 30mg IV oxy would not be worth putting a needle in my arm for effects unless I was in WD and had nothing else but 500mg tianeptine would be almost morphine like histamine type release that starts low and builds higher and is almost too much by the time it gets to between the balls and asshole. And keep me more well for longer.
I believe MOR is responsible for almost all the effects. I'm not even sure if the whole SSRA thing was ever much more than a theory.
Having said that there certainly is more than just MOR effects goin on there especially at supratherepeuric doses.
I'd love to know what oral tianeptine ba is compared to IV which I presume is 99-100%.
I thought it was very high but maybe not because 30mg IV oxy would not be worth putting a needle in my arm for effects unless I was in WD and had nothing else but 500mg tianeptine would be almost morphine like histamine type release that starts low and builds higher and is almost too much by the time it gets to between the balls and asshole. And keep me more well for longer.
Don't plug it. It is somewhat caustic. 500mg of tianeptine sodium would be excessive if you had no tolerance. Not an overdose but unnecessary. 250mg should be plenty to give a sense of its effect.
Tianeptine is not associated with serotonin syndrome. It isn't really serotonergic.
Sky God
Bluelighter
Tianeptine
From Wikipedia, the free encyclopedia
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Tianeptine
| Chemical and physical data | |
|---|---|
| Identifiers | |
| Pharmacokinetic data | |
| Legal status | |
| Clinical data | |
 | |
 | |
| Trade names | Stablon, Coaxil, others |
| Other names | S-1574;[1][2][3] JNJ-39823277; TPI-1062[4] |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Bioavailability | 99%[6][7] |
| Protein binding | 95%[7] |
| Metabolism | Hepatic[7] |
| Elimination half-life | 2.5–3 hours[6][7] 4–9 hours (elderly)[7][8] |
| Excretion | Urine: 65%[6] Feces: 15%[7] |
| IUPAC name[show] | |
| CAS Number |
|
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.131.750 100.069.844, 100.131.750  |
| Formula | C21H25ClN2O4S |
| Molar mass | 436.95 g·mol−1 |
| 3D model (JSmol) | |
| SMILES[show] | |
| InChI[show] | |
|
Tianeptine has antidepressant and anxiolytic effects[9] with a relative lack of sedative, anticholinergic, and cardiovascular side effects.[7][1
Tianeptine
From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Tianeptine
Tianeptine, sold under the brand names Stablon and Coaxil among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome.[1][2][3]
Chemical and physical data Identifiers Pharmacokinetic data Legal status Clinical data Trade names Stablon, Coaxil, others Other names S-1574;[1][2][3] JNJ-39823277; TPI-1062[4] AHFS/Drugs.com International Drug Names Routes of
administrationBy mouth ATC code Legal status Bioavailability 99%[6][7] Protein binding 95%[7] Metabolism Hepatic[7] Elimination half-life 2.5–3 hours[6][7]
4–9 hours (elderly)[7][8]Excretion Urine: 65%[6]
Feces: 15%[7]IUPAC name[show] CAS Number
- 72797-41-2
30123-17-2 (sodium)
1224690-84-9 (sulfate)PubChem CID IUPHAR/BPS ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA) ECHA InfoCard 100.131.750 100.069.844, 100.131.750 Formula C21H25ClN2O4S Molar mass 436.95 g·mol−1 3D model (JSmol) SMILES[show] InChI[show]
Tianeptine has antidepressant and anxiolytic effects[9] with a relative lack of sedative, anticholinergic, and cardiovascular side effects.[7][1
Here is the relevant information:
Tianeptine[35]
| Site | Ki (nM) | Species | Ref |
|---|---|---|---|
| MOR | 383–768 (Ki) 194 (EC50) | Human | [11][35] [11] |
| DOR | >10,000 (Ki) 37,400 (EC50) | Human | [11][35] [11] |
| KOR | >10,000 (Ki) 100,000 (EC50) | Human | [11][35] [11] |
| SERT | >10,000 | Human | [35] |
| NET | >10,000 | Human | [35] |
| DAT | >10,000 | Human | [35] |
| 5-HT1A | >10,000 | Human | [35] |
| 5-HT1B | >10,000 | Human | [35] |
| 5-HT1D | >10,000 | Human | [35] |
| 5-HT1E | >10,000 | Human | [35] |
| 5-HT2A | >10,000 | Human | [35] |
| 5-HT2B | >10,000 | Human | [35] |
| 5-HT2C | >10,000 | Human | [35] |
| 5-HT3 | >10,000 | Human | [35] |
| 5-HT5A | >10,000 | Human | [35] |
| 5-HT6 | >10,000 | Human | [35] |
| 5-HT7 | >10,000 | Human | [35] |
As we can see, tianeptine isn't particularly serotonergic (at least not directly).
Sky God
Bluelighter
@negrogesic i have no clue about the effects on serotonin, i just figured all antidepressants kinda worked the same .
Tryptamite
Bluelighter
Skygod what you posted from wiki says that tianeptine is an atypical antidepressant. As in not usual.
Zephyn
Bluelighter
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Absolutely not an overdose? I haven't used opioid in over 6 months but whenever I do usually I find i have a sort of permatolerance. But assuming I had absolutely no tolerance could 500mg be an OD? What about plugged/IV?
Somewhat caustic meaning it could cause internal damage or just be a little uncomfortable?
There are no guarantees with any of this stuff.
And OD simply means you taken too much so by that definition, sure it could be OD. You might not die but it could be uncomfortable.
Why not just take 200mg and see how it goes. Or 100mg for that matter.
It might be uncomfortable plugged. But the oral bioavailability is very high so there is no need. I think i tried it once and it wasn't much different than oral.
Do not inject it. In water it turns into a very sticky solution that hardens into nail polish like lacquer. Not something you want in your veins.
Zephyn
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Also, just how addictive do you find it? I'm hearing bad things but I've been a chipper with opioids for a decade. Oxycodone, no problem doing one day and forgetting it. Even heroin I can stop. Though some high potency BTH was more difficult. How does it compare to other opiates?
Similar to oxycodone perhaps in addiction potential, which is to say, extremely high.
Zephyn
Bluelighter
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I impulsed and bought a bottle of some shitty company who sells tianeptine supplements from a kratom shop. Was a little worried of winding up on a binge early on in my recovery, so I figured this was an alternative without investing in a ton of stock. From reading online, each capsule contains roughly 50mg of tianeptine. Took 5, waited an hour, felt nothing. Took the remaining 10 and I've got a mild opiate like buzz, reminiscent of kratom but with a more traditional effect. Certainly don't find it very fiendish. Must be prepared with the salt type that is like the delayed release.
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Zephyn
Bluelighter
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Yeah I'd probably put it up there with heroin due to the short half-life and effects. This is from a single use though. Even a single use of heroin wouldn't cause a craving for more this fast. Id say its more addictive than oxycodone, but less so than heroin, at least in an immediate sense. This stuff could be a recipe for disaster for people that can't stop using opiates.
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SKL
Bluelight Crew
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Don't IV this stuff. Not only is it caustic as someone mentioned—you can feel it as you inject, it's a warm sensation like getting propofol for anesthesia—it doesn't dissolve properly in water (the volume of water in a syringe, anyway), so even if the shot looks well dissolved (it may actually look milky) there are still a lot of particles floating around. I don't need to say how dangerous this is. Missed shots are also very painful and ugly.
Freudzilla
Bluelighter
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I went through 5 grams of this stuff several years ago. I remember mixing it with phenibut increased the nodding effect quite a lot but I remember my doses weren’t that high 150mg to 1.5G phenibut ..it wasn’t extremely fiendy as far I remember but stimulants and such were my fix at the time. Only recently have I gotten more into opiates/opioids and benzos/downers been meaning to revisit it as opioids have proven quite difficult to acquire a prescription for.