straight from nature, dried & harvested?
no.
so, shrooms, cannabis, amanita, poppies, no moral question here.
isolated or synthesized drugs that have high harm & addiction potentials?
yeah drug dealing in these circumstances is immoral when you seee someone itching and sell them a bag or a bundle. responsible dealers cut people off.
if you only care about money, and don't give a shit about people's welfares, then you are both predator, & parasite, intentionally & carelessly making a living off people's suffering. no better than government or chemical & pharmaceutical companies.
psychedelics, excluding LSD, these are fine isolates, & synthetics; DMT particularly; i think it should be an accepted part of one's initiation into adulthood.