polymath
Bluelight Crew
^ Quite unusual that this only has the N atom corresponding to the indole nitrogen... I tried to think of an ibogaine/harmala kind of derivative but you obviously can't build that from this compound.
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I Like to Draw Pictures of Random Molecules
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polymath
Bluelight Crew
Pawhuskin A is a cool compound, non-nitrogenous kappa receptor (mainly) blocker.
You could probably use that as an addition to a non-selective opioid agonist like the akuamma alkaloids, which bind more to kappa than mu receptors and therefore aren't very euphoric by themselves. Much like the "blue velvet" mixture of pentazocine and an antihistamine (I guess that mixture works because the sedative antihistamine potentiates only the mu agonist effect and not the kappa).
Edit: someone with any level of actual physical dependence to opioids probably shouldn't try balancing like that, tho...
You could probably use that as an addition to a non-selective opioid agonist like the akuamma alkaloids, which bind more to kappa than mu receptors and therefore aren't very euphoric by themselves. Much like the "blue velvet" mixture of pentazocine and an antihistamine (I guess that mixture works because the sedative antihistamine potentiates only the mu agonist effect and not the kappa).
Edit: someone with any level of actual physical dependence to opioids probably shouldn't try balancing like that, tho...
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polymath
Bluelight Crew
The 4-amino version of methylphenidate is significantly more potent than MPH itself, but can't know if it has aniline-like toxicity...
The SwissTargetPrediction also gives it a slim chance of binding to mu receptor.
If someone were to make a non-amine MPH with the piperidine nitrogen removed or replaced with oxygen, it would be easier to purify if it had an amino group on the benzene ring.
Edit1: Also, making it a 4-aminoethylphenidate gives it a little bit more likelihood of binding to mu receptor, similar to meperidine SAR.
Edit2: And, by reducing the shit out of antibiotic chloramphenicol, you could obtain an equivalent 4-amino version of amphetamine.
The SwissTargetPrediction also gives it a slim chance of binding to mu receptor.
If someone were to make a non-amine MPH with the piperidine nitrogen removed or replaced with oxygen, it would be easier to purify if it had an amino group on the benzene ring.
Edit1: Also, making it a 4-aminoethylphenidate gives it a little bit more likelihood of binding to mu receptor, similar to meperidine SAR.
Edit2: And, by reducing the shit out of antibiotic chloramphenicol, you could obtain an equivalent 4-amino version of amphetamine.
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polymath
Bluelight Crew
The essential oil of aniba canelilla tree is unusual in containing a nitro compound, 1-nitro-2-phenylethane... That could be used in producing alpha-benzylphenethylamine, but unfortunately that compound doesn't seem to be an amphetamine-like stimulant.
www.sciencedirect.com
Pharmacological characterization of BNMPA (α-benzyl-N-methylphenethylamine), an impurity of illicit methamphetamine synthesis
α-Benzyl-N-methylphenethylamine (BNMPA), an impurity of illicit methamphetamine synthesis, has previously been reported to produce convulsions in mice…
polymath
Bluelight Crew
Some new compounds here (the first and the third image):
www.swisstargetprediction.ch
www.swisstargetprediction.ch
www.swisstargetprediction.ch
For some reason the Swiss Target Prediction thinks that the N-(indolylethyl)piperazine is a better dopamine reuptake inhibitor than either N-benzylpiperazine or N-(indolylmethyl)piperazine.
SwissTargetPrediction
www.swisstargetprediction.ch
SwissTargetPrediction
www.swisstargetprediction.ch
SwissTargetPrediction
www.swisstargetprediction.ch
For some reason the Swiss Target Prediction thinks that the N-(indolylethyl)piperazine is a better dopamine reuptake inhibitor than either N-benzylpiperazine or N-(indolylmethyl)piperazine.
polymath
Bluelight Crew
A really dangerous idea:
make a quaternary ammonium compound from the antiglucocorticoid mifepristone, and take it as a peripheral glucocorticoid blocker with a huge dose of dexamethasone to get only the CNS effects of the latter.
make a quaternary ammonium compound from the antiglucocorticoid mifepristone, and take it as a peripheral glucocorticoid blocker with a huge dose of dexamethasone to get only the CNS effects of the latter.
polymath
Bluelight Crew
A compound that is both a kappa antagonist (Ki = 8.13 nM) and dopamine D2 and D3 agonist (Ki = 64.4 nM and 21.8 nM)... Maybe this could be some kind of an atypical antidepressant or ADHD medication. No chiral carbon atoms in there, so no confusion about the affinity of each isomer.
polymath
Bluelight Crew
3,4-dichloropemoline
www.swisstargetprediction.ch
Nothing seems to be known about this. If its dosage in mg is like 10 times less that that of pemoline, it could have less liver toxicity, but that advantage disappears with stimulant tolerance.
SwissTargetPrediction
www.swisstargetprediction.ch
Nothing seems to be known about this. If its dosage in mg is like 10 times less that that of pemoline, it could have less liver toxicity, but that advantage disappears with stimulant tolerance.
blueberries
Bluelighter
Hydrolicyclomethylamine (HCMA):
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Nagelfar
Bluelight Crew
I've always mused about near methylphenidates that were also near fentanyls.
...
Wishing I had the specs to this one below, tried against the phenyltropanes.
Note the C1 position substitution, not a mistake, though maybe add a C2 position carbmethoxy
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polymath
Bluelight Crew
I drew some amine compounds like this in another thread:
It's a possible dopamine reuptake inhibitor and also looks a bit like fentanyl or meperidine, and a pharmacology app predicts it's a possible mu receptor ligand.
Nagelfar
Bluelight Crew
Reminds me of Org 6582:
or Butyltolylquinuclidine:
Really they all turn out to be Zoloft analogues, more or less.
sekio
Bluelight Crew
"cannabinosides", glycosylated cannabinoids
NSFW:
Sweet!
polymath
Bluelight Crew
Reminds me of Org 6582:
or Butyltolylquinuclidine:
Those have a quite different connectivity, because the shortest distance between phenyl and nitrogen is only two carbon atoms. The compound in my post is more like 4-benzylpiperidine.
blueberries
Bluelighter
No-one want to to comment on my "Hydrolicyclomethylamine" ??
**Got the nomenclature wrong in the first!**
**Got the nomenclature wrong in the first!**
sekio
Bluelight Crew
ibuprofen-phenylephrine prodrug
(phenylephrine is garbage unfortunately)
so why not
in the spirit of dibenzoylmorphine / dinicotinylmorphine, morphine di-acetylsalicylate aka morphine di-aspirinate
fix your headache "for real"
(phenylephrine is garbage unfortunately)
so why not
in the spirit of dibenzoylmorphine / dinicotinylmorphine, morphine di-acetylsalicylate aka morphine di-aspirinate
fix your headache "for real"
Nagelfar
Bluelight Crew
Still reminds me of them. 4-BP is like a once lengthened phenmetrazine
P.S. would somebody direct me to a on phone free molecule renderer
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sekio
Bluelight Crew
Oxycodone 14-(3-phenylproprionate) is apparently some ~400x more potent than oxycodone, 14-pentanoyl 133x, 14-heptanoyl 200x, even the 14-acetyl is more potent by almost 10x.
Reading through Opiates by George Lenz... cool book.
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