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changing metabolism of nutmeg= different metabolites & effects?

I know this thread is years old, but after reading through the pages, my curiosity has been sparked.

I have tried nutmeg three times before with little to no results. I'm trying it out now and included the black pepper. If anyone cares, I'll report back later.
 
amberkd said:
I know this thread is years old, but after reading through the pages, my curiosity has been sparked.

I have tried nutmeg three times before with little to no results. I'm trying it out now and included the black pepper. If anyone cares, I'll report back later.
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I care.

This thread hits the nail on the head...
 
this thread was really interesting I'd love to see some more experience reports if people have tried this.

I drank approximately 10g of generic preground nutmeg and approximately 1 of generic preground back pepper,
this was my first attempt so I decided to go with a low dose. I drank both in water (will use milk next time, 10g of nutmeg in water made me quite nauseous).

about 3 hours later I was p cooked, felt a lot like weed but more clear and very little to no anxiety! I can't smoke without sketching so this was very enjoyable to me.

I didn't get any visuals, but I did do a quite low dose. the hopeful dude in me likes to think that I saw the beginning of visuals, I plan to try a higher dose in the near future.
edit: I did get geometric patterns forming when mixed with nitrous oxide.

less than a dollar for a day baked and not sketchy was a success in my eyes anyway tho :D
also the hangover was pretty much non existent.
 
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^ if you were pleasantly effected at that dose I wouldn't go much higher. It can get pretty uncomfortable and last multiple days with a shitty hangovers type effect. I've never done nutmeg but I've read enough to know this is truthful. Increasing your dose slightly may lead to a better experience but all the effects you described sounded positive and the fact u didn't get a hangover means that probably is a good dose for you. Be careful and remember this stuff can be toxic . Peace
 
Dr Mamba said:
I agree, tried this combo, with beef and potatoes, and had a completely different experience than nutmeg alone, TR later.
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When You mister & ppl like you (and me as welly well) will start to please stop bitching no offence the Messiah (perfection, anarchopeace, a tiny peace of brighter World we had back few decades ago multiplied endless & universalized, etc, you call) Will come. OR, I haven't took inuff & am lack of humor, or both.

Why in the mid of a dedicated thread ?
 
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Lass414b said:
Can someone way smater than me explain how this may affect the nutmeg experience; https://link.springer.com/referenceworkentry/10.1007/978-3-642-22144-6_184
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I think the only ways how black pepper could affect the nutmeg high are enzyme inhibition, increased BBB penetration (because of P-glycoprotein inhibition) or the terpene compounds of BP synergizing with the nutmeg compounds.

Combining small doses of nutmeg, rosemary and black pepper seemed to produce a less hallucinogenic and more relaxed high than nutmeg only (did this a few days ago). All of those spices contain alpha-pinene which is a benzo-like sedative, but the more toxic components are different in each (safrole in nutmeg, eucalyptol in rosemary).
 
I've read that this is true for alcohol, if I'm understanding right, that the effect/mechanism varies on concentration, and we can infer it does based on other minor psychoactives that are present in the varying forms of a drink.
 
Piperine can form an adduct, or however your say it, with Oxoelemicin called Oxoelemicinphenethylamine which is supposedly a strong psychedelic.. Oxoelemicin is a metabolite of Elemicin, and there's piperine in nutmeg itself so it may not just be metabolism at play, well besides that Elemicin would first have to metabolize into Oxoelemicin. Check out my latest thread I just posted about it earlier called Oxoelemicinphenethylamine.
 
The Holy Quadruplty said:
Piperine can form an adduct, or however your say it, with Oxoelemicin called Oxoelemicinphenethylamine which is supposedly a strong psychedelic.. Oxoelemicin is a metabolite of Elemicin, and there's piperine in nutmeg itself so it may not just be metabolism at play, well besides that Elemicin would first have to metabolize into Oxoelemicin. Check out my latest thread I just posted about it earlier called Oxoelemicinphenethylamine.
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To clarify, it is the amine called piperidine which can form an adduct with 1-oxoelemicin producing 1-oxoelemicin-pideridine. The same adduct formation appears to occur with plain phenethylamine forming 1-oxoelemicin-PEA.

Nutmeg can contain at least 3 allylbenzenes, myristicin, elemicin & safrole which can all form 1-oxo metabolites. Unfortunately not all nutmeg is guaranteed to contain these since geographical location and the type of nutmeg matters. On the other hand, mace is a more reliable source of these 3 allylbenzenes (mace is the seed covering of nutmeg).
 
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Allylbenzene said:
To clarify, it is the amine called piperidine which can form an adduct with 1-oxoelemicin producing 1-oxoelemicin-pideridine. The same adduct formation appears to occur with plain phenethylamine forming 1-oxoelemicin-PEA.

Nutmeg can contain at least 3 allylbenzenes, myristicin, elemicin & safrole which can all form 1-oxo metabolites. Unfortunately not all nutmeg is guaranteed to contain these since geographical location and the type of nutmeg matters. On the other hand, Mace is a more reliable source of these 3 allylbenzenes. Mace is the seed covering of nutmeg.
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Wait what, I thought all Nutmeg contains Myristicin, Elemicin, and Safrole?! 🤔🧐
 
polymath said:
Combining small doses of nutmeg, rosemary and black pepper seemed to produce a less hallucinogenic and more relaxed high than nutmeg only (did this a few days ago). All of those spices contain alpha-pinene which is a benzo-like sedative
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There's also trimyristin (toxic anxiogenic fat) & an FAAH inhibitor (pro-endocannabinoid) in whole nutmeg which are both sedating.

Some of the nutmeg volatiles:
borneol
camphene
limonene
geraniol
pinene
terpineol
myristicin
safrole
elemicin

• Camphene causes headache, dizziness, tiredness, nausea and vomiting, and even unconsciousness. It's not something you really want to ingest a lot of. It's very likely one of the reasons many people don't enjoy Nutmeg oil.
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I think, like elemi oil, nutmeg is a diamond in the rough. It needs some refinement. While nutmeg oil is said to be much more psychedelic with less side effects that the nuts themselves, there’s still some cleanup that needs to be done. The oil contains a lot of toxins that really should be removed. Potent sedatives like myrcene present in both elemi oil and nutmeg will mess up their psychedelic effects. There are many other compounds that are active that aren’t psychedelic.
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Numerous CNS activities have been reported for nutmeg. Olajide et al. (Olajide et al., 1999) reported that oral administration of the chloroform extract of nutmeg (50–200 mg/kg) possessed a potent analgesic effect against acetic acid-induced writhings in mice. On the other hand, Sonavane et al. reported that trimyristin and the acetone insoluble fraction of the hexane extract of the seed demonstrated anxiogenic activity in mice (10–100 mg/kg and 30–300 mg/kg, i.p., respectively)
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https://doi.org/10.1016/j.jep.2009.08.026
 
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