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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

Not him, but I take 75mg per day for medical purposes. When I feel like getting high I take ~1g (I have a script for 250 mg daily so saving pills isn't a problem, I don't take 250 mg daily because the difference in medical purposes between 75 mg and 250 mg is negligible). If I wanted to get high the next day I'd need at least 1.5g if not 2g for the same effect. After around a week 1g is enough to get high again. Even during this time the 75mg for medical purposes continues to work fine.

I've been of it for a few weeks if I ran out and forgot to refill my script and didn't feel any wd or whatever. Just the medical effects faded after a few days.

My script is for anxiety for which it works but not super well, however it also makes my back totally pain free which is the main reason I take it.
 
Searing75 said:
I despise Lyrica! The worst sexual side effects I have ever experienced were from Duloxetine. Or, as it’s commonly known as........Cymbalta. Works well for neuropathic pain though.
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Not quite following you, but Lyrica has definitely had a negative impact on my libido and ability to perform. I think its partially the analgesic effect leading to reduced sensation as well as mental 'dullness' that makes getting to that heightened orgasmic state really difficult.

That said, high enough doses make me horny as fuck and in the mood to do all sorts of fucked up shit, but the lower daily dose I take (300mg) only really has a negative impact. I would consider it close to opiates in terms of its anti effect of libido, but SSRI's have been the shit that has totally blocked me from orgasm.
 
Based on its half life if you want to use it every day just leave a full 24 hours, plus 7 hhours. So if on Monday you took it at 6am, on Tuesday you take it at 13:00 (6 am plus 7 hours).
I don't recommend daily dose, but if thhe purpose is to get high for a little binge just wait one full 24 hour cycle, plus 7 hours.
Try it and see.
 
Forever Changes said:
how many days clean can you go before tolerance is set to zero?

and what doses do you normally take?
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I cut by 50% per day about every 3-5 days. Then by 25% when I get down to 100 mg daily. Begin by stabilizing at two doses per day.
Ex: Starting from 600mg daily.
Day 1= 600 mg(300 mg at morning, 300 mg at evening)
Day 2-6=300mg(150 mg morning, 150 mg evening)
Day 7-11=150mg(75mg morning, 75 mg evening)
Day 12-16=100mg(50mg am, 50mg pm)
Day 17?21=75mg at evening only
Day 22-26=50mg at evening only
Day 27-31=25mg at evening only
Then zero

The evening dose is about 2 hours before bedtime because thats when the drowsiness from Lyrica hits me. If youre in a hurry, I would cut those days down to 3 days per step. The slow-down at 100mg is important to avoid wds.
NOTE- I have to open my capsules and separate the powder into equal piles with a razor blade to get the specific doses. Ex: 150 mg capsule: 1/2= 75 mg, 1/3= 50mg, 1/6= 25 mg. Its not as hard as it sounds but you have to lick up your doses from the plate and Lyrica tastes AWFUL.
 
Jamespd27 said:
IMO some generic versions are pants
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I've used generic and they definitely had an effect but they were genuine medications (ie. from a legitimate pharmaceutical source). If you acquire it from a dubious source then who knows. The generic is much cheaper
 
Squeaky said:
I cut by 50% per day about every 3-5 days. Then by 25% when I get down to 100 mg daily. Begin by stabilizing at two doses per day.
Ex: Starting from 600mg daily.
Day 1= 600 mg(300 mg at morning, 300 mg at evening)
Day 2-6=300mg(150 mg morning, 150 mg evening)
Day 7-11=150mg(75mg morning, 75 mg evening)
Day 12-16=100mg(50mg am, 50mg pm)
Day 17?21=75mg at evening only
Day 22-26=50mg at evening only
Day 27-31=25mg at evening only
Then zero

The evening dose is about 2 hours before bedtime because thats when the drowsiness from Lyrica hits me. If youre in a hurry, I would cut those days down to 3 days per step. The slow-down at 100mg is important to avoid wds.
NOTE- I have to open my capsules and separate the powder into equal piles with a razor blade to get the specific doses. Ex: 150 mg capsule: 1/2= 75 mg, 1/3= 50mg, 1/6= 25 mg. Its not as hard as it sounds but you have to lick up your doses from the plate and Lyrica tastes AWFUL.
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thanks. So it takes a whole month?

yeah I have the 300mg capsules so have had to open them up to dose properly. Actually I think it's simpler to just snip off one end with some scissors rather than twisting them
 
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Forever Changes said:
thanks. So it takes a whole month?

yeah I have the 300mg capsules so have had to open them up to dose properly. Actually I think it's simpler to just snip off one end with some scissors rather than twisting them
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If you want to completely avoid withdrawals, yeah. That is what works for me. You can do it in two weeks by cutting the time frames in half, but you will be feeling a bit crappy most of the time.
As for the capsules: I twist them open and save the empty capsules. When Im taking partial caps and I have to be away from home, I refill the empties so Im not doing it in the bathroom at work.
 
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is Pregabalin a CNS depressant? Do we have to be careful with ODing?

I took 1200mg in one go - that's not excessive, is it?
 
Forever Changes said:
is Pregabalin a CNS depressant? Do we have to be careful with ODing?

I took 1200mg in one go - that's not excessive, is it?
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Yes, it's a CNS depressant, but I think taken on it's own respiratory depression shouldn't be a problem. In combination with other drugs it might be a problem:
This study found that there was no significant difference between respiratory depression and sedation among those who received gabapentinoids and those who did not.
In a previous small cohort study of nine patients, 44% of patients experienced respiratory depression and/or sedation with the combination of gabapentinoids and opioids with dosages of gabapentinoids administered as high as 3,600 mg/d.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691933/
 
There arent any stories floating around about overdosing on Lyrica or gabapentin. Theres always a way to overdose(you can die from drinking too much water), and theres always a chance of you having an unusual reaction. SO- you need to be careful.
 
Man, tolerance really builds with Pregabalin. I took 1500mg last night and felt almost nothing. Time for a few days break

Don't quote me on this but I think having an empty stomach helps, or at least makes the onset more rapid. I also snip off the ends of the capsules before swallowing in case they don't all dissolve in the stomach
 
I took Lyrica in the past 2 days. 2 days ago i had great feeling of being relaxed and happy. Yesterday I took the same ammount and I barely felt anything so I took more and I had different feeling. How many days of break I need to have in order to have the same feeling after taking same ammount of Lyrica as for the first time 2 days ago?
 
Empty stomach is always best for fast absorption. I like to open the capsules, pour the powder in my mouth, and then swallow the powder and capsules together. The powder tastes like a dogs butthole, but onset is definitely faster and more acute.
 
^It wears off a lot quicker though ime.

BlazeV said:
I took Lyrica in the past 2 days. 2 days ago i had great feeling of being relaxed and happy. Yesterday I took the same ammount and I barely felt anything so I took more and I had different feeling. How many days of break I need to have in order to have the same feeling after taking same ammount of Lyrica as for the first time 2 days ago?
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It depends on the dose but I would wait at least 1 week. It only works days in a row if you massively escalate the dose. Not advised at all. It is what leads to dependance and the very difficult withdrawal.
 
Swallowing capsules whole means slower absorption, thus you feel it while there is still some to be digested. Opening capsules equals instant absorption and the effects are 100% immediately, with nothing left to get into your blood later. Imagine the difference between doing a shot of tequila on an empty stomach vs drinking a whole margarita with dinner.
 
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