There is plenty of data supporting ketamine alleviating depression. Ketamine infusion therapy seems to be becoming much more mainstream.
I'd be cautious giving the recreational perspective though. Anecdotal reports from drug users may do more harm than good.
I dunno how well something like 3meo would go when used therapeutically. The manic effects being reported would probably be seen as clinically concerning. Manic state or hypomania isn't necessarily alleviation of depression but an 'artificial' state of intoxication. There's no doubt in my mind that it impairs judgement. MXE is something I can see being more widely tolerated, the stimulating effect is less manic and the dissociative effect is somehow navigable (its fucking beautiful too
). Its design by our illustrious but absent Bluelight legend for recreational use may come with stigma.
Ketamine doesn't cause mania IME, and doesn't cause much stimulation. The dissociative effect is incredibly pronounced though and highly hallucinogenic which could be problematic for therapeutic use. But the MOA behind its relief of depression is solid and, given its decades of medical use, risk is well quantified with safety protocols firmly established. I think ketamine would be the most likely to be accepted arylcyclohexylamine* for depression.
I wonder if nitrous oxide has any such utility?
Good work xammy
Fwiw, I truly think these drugs can be truly positive in personal, spiritual and clinical sense.
This topic could be interesting in the main forum. I'd like to hear the general communities perspective on this.
*somehow the complexity and technical nature of that word really suits the sci-fi nature of dissociatives.