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I Like to Draw Pictures of Random Molecules

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Must be your screen resolution then...

I don't know about that 'getting high' event but the structure would be what Shulgin called A for amylescaline. Not pentescaline since P is used for proscaline. It's in the B / buscaline entry. Not that promising?

Personally I'd be curious what is beyond MAL? Say isobuscaline or even neopentescaline..
Then again the thio's or haloalkyls could be just as promising - like say a 2C-T-7 (fluoropropylthio) analogue?
 
"Expand on this event?"

Before I had finished the drawing, I noticed small figures of usually naked men all over my room. I saw my grandfather who is dead watching me from a picture frame. I looked out the window and saw armed soldiers from V for the Visitors charging me from the woods. There was a man on the back porch shrinking my now (I thought) dead roommate's head. He disappeared every time I walked out there. The overall feeling was that of floating, and it felt very ethereal.. I saw my raver friends in the reflection of the windowpane. They could see me too. Some of them appeared to be mainlining some kind of very pleasurable drug through butterfly needles with ultra thin tubing. The overall feeling was that of being in heaven. There was a fairy in the windowpane playing a flute which I could not hear. He appeared shocked when he saw that I could see him.
 
Designer In the News..Early warning
US HR bill to put synthetic opioid 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide aka W-18 on Synthetic Drug Control Act. So far it is completely legal technically as it doesn't look like analog of anything (save far far fectched fentanyl!!!!) I guess that will include all its analogs. H.R. 3537 21 December 2015

4-chloro-N-%5B(2E)-1-%5B2-(4-nitrophenyl)ethyl%5Dpiperidin-2-ylidene%5Dbenzene-1-sulfonamide.png




Wiki entry :
1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18) is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. It was invented by the chemists Edward Knaus, Brent Warran and Theodore Ondrus in 1981.[1]

This compound was found to be around 10,000x more potent than morphine in animal studies.[citation needed]

It has never been studied in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.[original research?] .. and blabla and blabla
Click to expand...
 
amazing! remove the nitro of W18 and the activity decrease dramatically: W15 is only around 5 times more potent that morphine in animals

4-chloro-N-%5B(2E)-1-%5B2-(phenyl)ethyl%5Dpiperidin-2-ylidene%5Dbenzene-1-sulfonamide.png
 
Nitro group increases potency by 20,000. Wow. Have they explored other substitutions?

Where did you get the short half life from?
 
I know, right. I can only imagine what

1-(4-nitrophenyl)-2-aminopropane.png


would do ( kill you?) and what its proper dosage would be?

Or check this out

1-phenyl-1-nitro-2-aminopropane.png


Wow, talk about death by adrenergia!
Or this

1-(2,4,6-trinitrophenyl)-2-aminopropane.png


TNT-AMP

An explosive amphetamine!
 
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aced126 said:
Nitro group increases potency by 20,000. Wow. Have they explored other substitutions?

Where did you get the short half life from?
Click to expand...

baseless speculation on my part to be honest, was more asking the question
 
More improved NTs. The first two might be almost sedating!

1-(3,4-dihydroxyphenyl)-2-ethylaminoethane.png


(1R)-1-(3,4-dihydroxyphenyl)-2-ethylamino-1-hydroxyethane.png


Now, forget about toxic catechols!

1-(3,4-dichlorophenyl)-2-aminoethane.png


1-(3,4-dichlorophenyl)-2-methylaminoethane.png


1-(3,4-dichlorophenyl)-2-ethylaminoethane.png


(1R)-1-(3,4-dichlorophenyl)-2-amino-1-hydroxyethane.png


1-(3,4,5-trichlorophenyl)-2-aminoethane.png


1-(2,4,6-trichlorophenyl)-2-aminoethane.png


1-(2,4,5-trichlorophenyl)-2-aminoethane.png


1-(4-chlorophenyl)-2-aminoethane.png


1-(3,5-dichlorophenyl)-2-aminoethane.png


So many different ways to set up the nervous system!

These chloro improved neurotransmitters cannot be 3-methoxylated to the inactive vanillin derivates like catechols are.

Ok, back to reality. Is the methcathinone research chemical fad over already? I think it might be, but ever since safe or scam went offline, I don't buy research chems blindly.

1-(2-methoxy-4-methylphenyl)-1-oxo-2-methylaminopropane.png


And what about this one

1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-aminopropane.png


from sesamol? I think it might metabolize into the dreaded

1-(2,4,5-trihydroxyphenyl)-2-aminopropane.png


after crossing the BBB and reek havoc on the CNS of whatever mammal is unlucky enough to have ingested it, but that could be based on some kind of urban myth that the latter compound is terribly neurotoxic if injected into the brain. Otherwise, it's not about to cross the blood brain barrier. It's even worse at that than

1-(3,4-dihydroxyphenyl)-2-aminopropane.png


Don't know what the minor (1 percent) metabolite of amphetamine

1-(4-hydroxyphenyl)-2-aminopropane.png


does exactly, except I think they use it in eye drops to dilate one's pupils? And I think its log P is good enough to predict it will diffuse across the hydrophobic blood brain barrier. Does anybody have any information on 4-OH-AMP?

Disrespect my prolific pen as I send the minds of the weak to rise and take power over the land as we stand a solitary piece of sand let the mind use the physical as planned.
 
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thx @Incunabula ..actually I thought of adding a dash of LSD:

LSSD_zpsawou1gry.png


you ended up like this:

shulgin2_zpss5i8rywp.png


I wouldn't trip on that tho! half-life would probably be WEEKS not days as FLY already can last anywhere from 2 to 4 days!!! but it look nice. how you synthesize that? don't even ask! Would make nice student thesis with chiral versions and all that!!?
 
Whoever started the trend of graphing out every derivative down the line of whatever specific random molecule you post instead of just posting the single compound, die. :-P

Ever since I discovered that TSA chelated benzenes double the binding potency of DRIs without diminishing much else (someone correct me if it throws the LogP way off or the PSA or etc.)

Z0Fyl.jpg


Then I wondered, the electrostatic improvement of chelating the benzene thus; could it be transferred to a functional facet of DRAs too? Since DRIs and DRAs overlap, but DRAs smaller fits the substrate spot, what on earth would a chelated amphetamine do? Best case scenario in my wild imagination; the transitional metal makes it so, although it acts as a subtrate at MAT, it's unable to cross the cell membrane into the vesicular area (VMAT) perhaps then it just act as a substrate, phosphorylating MAT at the surface of the axon and not within it. Maybe even it wouldn't trigger autoreceptors as much that way?

SiJ6T.jpg


[η6-(D-N-methyl-amphetamine]tricarbonylchromium (??)
 
sekio said:
you may want to consider that Cr is not very nice for biological systems....
Click to expand...

What, me? Mr. Unintentional Energetic Molecule-Should-Make-Tool-Compounds-Over-The-Top-Chirality-Makes-Chemists-Wake-In-Cold-Sweat-From-Nightmares-'bout-'em Nagelfar? NaV blocking isn't either, nor is m-amp neurotoxicity (um. Just how *not nice* / 'toxic' are we speaking here sek?)
 
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