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The Big & Dandy 3-MeO-PCP Thread - Mad Manic Meo 3nity

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On an unrelated note, I want to support the recent debate about whether or not there is a radical difference between PCP and 3-Meo-PCP. The receptor binding data shows a very distinct difference. PCP has an affinity for Sigma2, and none for Sigma1, while 3-Meo-PCP has an affinity for Sigma1 and none for Sigma2.

What is the significance of this, from anyone who knows enough about neuropsychopharmacology?
 
There aren't really very useful selective ligands developed for the sigma receptors, making it difficult to isolate characterization of their functions.

Cell death, Anxiety, psychosis and depression or the prevention of them seem to be among possible effects mediated by agonism or antagonism of sigma receptors - sometimes apparently paradoxically.

What is interesting is that sigma1 agonism is thought to have neuroprotective effects via several ways: vs. oxidative and nitric oxide stress and calcium homeostatic imbalance
http://www.sciencedirect.com/science/article/pii/S1347861314000267
 
Solipsis said:
There aren't really very useful selective ligands developed for the sigma receptors, making it difficult to isolate characterization of their functions.

Cell death, Anxiety, psychosis and depression or the prevention of them seem to be among possible effects mediated by agonism or antagonism of sigma receptors - sometimes apparently paradoxically.

What is interesting is that sigma1 agonism is thought to have neuroprotective effects via several ways: vs. oxidative and nitric oxide stress and calcium homeostatic imbalance
http://www.sciencedirect.com/science/article/pii/S1347861314000267
Click to expand...

Bam. Thank you for helping affirm a hunch with some solid science. With this data we can begin to hypothesize applications and benefits of 3-Meo-PCP over PCP using the paradoxical mechanisms/mediations of Sigma1 vs. Sigma2.
 
I also did about 7 out of 14 days. The full moon was my last bit. I'm pretty baseline now, and overall I have a lot of glowing things to say, for the entire time was magical feeling, synchronous, rich, even the off days. It tuned me physically, mentally and energetically. I did have a couple days of 'insomnia' but it was more like half-sleep half-wake dreaming which was great fun, when the morning came I rode it out until I fell asleep early the next night.

The downsides? Craving it for a day or two after cessation.
Hypomania, which can be good when channeled, or destructive when untamed. Same with the psychosis/delusion potential. Keep a grip; ride the line but don't cross it! Play with the messages received, and work to distill the truth with reflection and grounding.
 
i also did feel a magical feeling. i'd say it gave me some positive insight as well. felt pretty easy on the body too. i'm still in recovery from a meth/speed gbl/ghb addiction and 3-meo is helping me come to terms with what happened. it made me think of the idea that i want to get two goldfish. big bulgy eyed muhfuckas naming one alfredo and one pablo
 
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Be very careful as you may be running increased risks of psychosis / mania with ghb withdrawal and stims probably don't help..

I myself have ceased taking 3-meo for about 5 days now with no intention of starting again like before. This is a terrible time to tell what problems should be attributed to what cause since I am generally in a pickle, but I am definitely missing that functional and stimulated anti-depressed state. Other than that nothing worthy of note.
 
I quit meth/euro speed and GBL/GHB 6 months ago. A couple relapses but what I mean is I'm using 3-meo to help me with the damage I did to myself during that period of time. When I was using the drugs I overexerted myself (pushups/sex) and fucked myself up really bad. Problems with my joints and jaw displacement from extreme bruxism on stims have persisted. My body has healed VERY slowly and it has been hell to say the least, I can say 3-meo has given me some relief recently that I really needed. I'm almost all healed but what I'm saying is 3-meo has helped me relax my muscles/joints/jaw so it could heal. The damage has caused tension and 3-meo has relieved it. I am feeling mentally well today from a good night of sleep.
 
Dont you think that you just dont feel the pain...because...yeah your taking a dissociative?
 
3-MeO-PCP is not a muscle relaxant, it does not relieve the tension it just numbs the pain. Just realize that you are delaying the healing process when you are ignoring damage and pain that is still there.

I know, because I am in a similar situation. Have not messed myself up quite as bad probably, but for the second time now I overexerted my neck (+shoulders) during dissociation. Fortunately I didn't take that high doses of 3-MeO-PCP so anything that went wrong I did feel the day after, it would be quite a bit worse if one were to continue being so dissociated and numbed that after damage, it is not acknowledged by sensing at least the pain (if not the full intensity).
 
I took a two week break and then went in with 6mg + 4mg at T+1hr. The mental space actually got a bit frustrating and I got caught in a loop. I was trying to remember the name of Eckhart Tolle whose lectures were recommend by a friend. I go through weeks where word retrieval is extra difficult and I was experiencing that /presque vu/ feeling times 100. Strange thing is thatwhile I find this chemical provides transparent self-perspective, it seemed to amplify the mental block to remembering the name. I tried very hard to not-try and rallow the verbal sphincter to release, and it actually worked. It was a good lesson.

I meditated and listened to E.T. and was definitely vibrating on his frequency. I want to re-listen to the lecture because in my memory it is almost stream-of-cosciousness hippie bullshit that was totally resonating with me. Like I was catching all of the super significant non-concrete vague spiritual gesturing. I'm being glib now but it felt alternately genuinely great and totally bogus.

I listened to a Pete Holmes podcast that was totally hilarious, his guests Josh Ruben does really insightful impressions. Found it hard to focus on decoding language, though.

I got up and went to the bathroom robo-walking a bit. Back in bed I listened to meditative music sitting in a lotus position. At one point I was rolling my neck and shoulders around and it felt awesome.

I dosed around 9pm and was up until 2am and the time really flew by. Took an Etizolam and slept pretty well until 9am.

Next morning I had a sharp pain in my right mid-back that stuck around all day. At first I thought it could be kidney pain but looking back I think I strained a muscle doing the shoulder roll thing. It is definitely important to bee careful with how you use your body on this stuff, think carefully about what you do and don't rely on physical feedback.

In the morning I felt a nice afterglow. I actually dosed 30ug of 1P-LSD, not wanting to return to drab reality. This was a mixed bag and was fun at times but left me feeling fried, which means another benzo, which I think explains the rebound anxiety I felt yesterday and today.

I feel that I am learning from this chemical but I need to use it more responsibly. I think 8mg is my sweet spot, and I need to start earlier in the night to avoid benzos, get better sleep, and just enjoy the glow the next day. I think it can teach a lot about meditation, like swinging a corked bat. It shows you what it would be like if it were easy, the you go back to lugging a 32-oz slugger.

Take care folks.
 
I would say the exact same thing aboit mxe and meditation you said about 3 meo pcp and meditation
 
axnow said:
I tried very hard to not-try and rallow the verbal sphincter to release, and it actually worked. It was a good lesson.
Click to expand...

yepyepwoah said:
I would say the exact same thing aboit mxe and meditation you said about 3 meo pcp and meditation
Click to expand...

I use dissociatives while doing creative writing. I have a rule that, if I'm feeling blocked in any way, I forget about my words, close my eyes and let go. I'm then taken away via a meditative state where my mind is quiet and vibration and sensation are all that remains. Finally, without my realizing it, I'm thinking again, and I land on an important thought. I am excited; my discursive brain awakens and my eyes open. I am ready to write. Never fails.
 
Flushed my 3meo, was making me loopy. If I continued I'd fail out of school and I was unable to control my use. Peace fellas
 
Congrats on your Desicion.....I ended up in rehab after a year of MXE.....dissos are a hard lot for some to control
 
Yepyepwhoa, my recent 3meo jaunt was actually about 3 weeks. The first week was every day, straight up. There was a lot of 'work' to do. After that I slowed down. The 4th week i did a small amount on 3 occasions when my gifts came back to me. I was grateful for that. Ecclesiastes 11:1. It just so happened i gifted to 7 or 8, afterwards I discovered this excerpt from the bible.

The amount done in this time can only be guessed very roughly. I know how much I started with, but the problem is that I gifted more than half of it over that time. I know I did enough to make many people cross the line, but I ride lines like its my job. I did have a christ consciousness complex for a minute, preaching prophecy and righteousness and repentence, but I'm good now. Still love Jesus though, something I had failed to ackowledge previously.

Axnow, synchronistic you mentioned Eckarte Tolle. Literally maybe 4 days ago his word came to me for the first time in many years, and I was compelled to give him a nod in the meditation section of my book.
 
My normal weight is 195.....after a year of MXE (ab)use I was down to 160.....haven't been that weight since HS (20 years ago)

The scariest part is I had no idea I was losing weight / not eating....I was so caught up in what I was dojng
 
That potent new batch is crazy dangerous shit. Had a full blown psychotic episode from it and the dosages weren't high (<10mg, but I also responded very strongly to it). Hell's open now, homeless, lost girlfriend and just escaped from psychiatric ward where they gave me chlorprothixene despite that I clearly stated not to tolerate any neuroleptics - another psychotic break, forensic station this time. Mad crazy people there. Escaped again. Here I am.

And I never had psychotic episodes or seizures before which didn't involve dopamine antagonists and now 3-meo-pcp.

Take care.
 
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