I Like to Draw Pictures of Random Molecules

[aced126]

Why do you want to increase electronegativity?

These compounds might struggle to get past the BBB.

 

[Nagelfar]

Why do you want to increase electronegativity?

These compounds might struggle to get past the BBB.

The acetoxy, at least, should have better BBB penetration. Electronegativity is supposedly a catch-all for meaning better @ MAT ligand affinity, speed of onset, etc. ask clubcard. I dunno the exact mechanism.

1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) *PLUS* delta-9-tetrahydrocannabinol (THC) :

Beside the phenylethyl tail, there's only the chloro and the two nitrogens difference

 

[Dresden]

 

[roi]

 

[belligerent drunk]

I like that. Now go and make me some!

 

[Nagelfar]

I like that. Now go and make me some!

Get the precursors together and some academically learned lab-certified assistants with product handling licensing and you've got it

 

[Dresden]

 

[aced126]

What's the idea of this?

 

[Dresden]

It's the phenyl to indole analogue of one of the most potent selective dopamine releasers found yet, which was first posted by Nagelfar.

 

[aced126]

I see, neat idea.

 

[roi]

Benzo prodrug:

 

[Nagelfar]

Doodles I made at my Intensive Outpatient group (IOP) from today.

 

[Nagelfar]

Forskolin + Salvinorin A = intermediate:

Carnosol had an interest center cyclohexane formation, it twists into a chair formation and I aligned it to the critical elements of butyltolylquinuclidine:

 

[Dresden]

(S)-p-METHYL-NICOTINE

 

[Nagelfar]

p-METHYL-NICOTINE

I like it. I think a lot more use could be made of the nitrogen heteroatom for drug-like compounds.

 

[Dresden]

I like it. I think a lot more use could be made of the nitrogen heteroatom for drug-like compounds.

Thanks.

 

[SKL]

methylenedioxypethidine. 4-fluropethidine and 3,4-dichloropethidine are apparently more potent as DRIs while retaining opioid analgesic effects so I wonder what we'd have here. could be a risk of nastiness, seizures, serotonin syndrome though ...

If MDPV and U-47700 had a bastard child ...

 

[Cristall1672]

Forgive me those of you who have read this question on two other threads, but I'm looking to gain knowledge before I proceed in vein. ( Like I've done before)
I'm wondering if anyone knows what brings about the variety of colors of mdp2p. My first batch was the ideal yellow. Realizing that I forgot to pour off the NaOh layer after the mdp2p distilled I did something kind of dumb without thinking. I know realize how senseless it was but I added hcl thinking it would cancel it out. Dumb Dumb Dumb. When I added the acid, it changed colors and turned blue! Of course, I freaked. So I added a little NaOh to cancel that one out. (Honestly looking back, I'm certain my adderal fix had a lot to do with my panic attack) Anyhow, it changed colors again, but not back to the color I was hoping. It's Red. . I'm wondering what the different colors mean for a molecule. Is it ruined??

 

[Dresden]

"Is it ruined?"

Probably, but we don't discuss chemistry on bluelight.

 

[aced126]

A free phenolic group is important for activity; ethers show very little mu affinity and as such only function as prodrugs (like codeine). The above molecules might eventually get metabolised to reveal the free phenolic group but probably not at great concentrations as other metabolites will likely result first like the cleavage of the ester.