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I Like to Draw Pictures of Random Molecules

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roi, your last contribution is interesting too. You don't see many cyclopropanes on monoaminergic-type drugs, but it's small enough you'd think it could work in some capacity.

5rYUS.jpg


The above is another one of my Super-Cocaines; this time based upon the benzoylthiomethylecgonine (but of course, not a benzoyl or methyl in this instance but augmented from Singh's 223f cocaine analogue for the phenyl branch + 219e's modification on the nitrogen and 200 replacing the carbmethoxy and 225c on the "6/7" tropane substitution position)
 
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sekio said:
i thought 5-chloro/5-bromo-MDA was known and active.
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5-halo-MDA's are known only to our imaginations, but I feel certain they are active (not the least reason of which is that 5-Me-MDA was reported by Nichols to be so). Which reminds me of this (probable dud) I thought of once:

2-amino-1-(3-ethyl-4,5-methylenedioxyphenyl)-propane.png


For some unknown reason, I named it GYPSY at the time. Yes, I am insane.

* * *

"The Master knows he is sick; therefore, he is not sick."--Lao Tzu.
 
(6) 2-chloro-MDA/MDMA is a thing (1, 2), but only used as precursor. Has been deteced in some ecstasy tablets. Never heard of 5-halogenated-MDxx.

edit: (6) 2-bromo-MDA is in PiHKAL, no effects at 350mg.
 
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2-methyl-MDA (really, 2-methyl-4,5-MDA, to be correct) is not active either, according to PiHKAL.
 
the second one could be active without the methoxy's

the piperidine probably would stop any psychedelia but big/weird substitutions on the alpha carbon and the nitrogen are usually tolerated on empathogens... just guessing
 
Dresden said:
3-benzyloxy-4-carbomethoxytropane.png


The ether bond is much more metabolically stable than an ester, making the cocaine analogue last about as long as MPH.

3-benzyloxy-4-methoxymethyltropane.png


A little bit more of a longshot, but the R-CH2OCH3 works for sufentanyl; obviously, to me anyway, this second cocaine analogue has the potential to work for a very long time indeed. And having lost the oxo off the benzyl, it will be a lot smoother and more focused than original cocaine; this is based on the analogy that methamphetamine (Ph-CH2-R') is focused and smooth, while methcathinone (Ph-(C=O)-R') is not [R' = 1-(methylamino)ethane].
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^Love these, Dresden.

Nagelfar said:
I was doing things *similar* but *not quite* a couple days ago on my Marvin Beans Sketch that I finally figured out to get on my home non-connected laptop.

Here's one that may be promising, reminds me of desoxypipradrol, but uses the phenyltropane configuration of the phenyls off of the piperidine instead of the MPH configuration with the nitrogen et al:

acYAd.jpg


Even reminds me a bit of nocaine or phenmetrazine.
Click to expand...

The above and Hammilton bringing Strobamine to my attention inspired a reprise as thus:

JgVb6.jpg
 
Theoretical Psychedelics: 4-Propionoxy-N,N-Dimethyl Tryptamine

I had the idea that the propionoxy group may be an acceptable 4 position substitution for tryptamines. I got the idea from ALD-52 and 1P-LSD. To those of you who don't know what the structure would look like, it's essentially 4-ACO-DMT with a methyl group sticking off of the top carbon of the acetyl group.

I think the extra carbon will make this molecule slightly less polar than 4-ACO-DMT, while still having the necessary exposed oxygen. Given this information I believe it could be slightly more potent, however my only worry is that this extra carbon could cause some receptor incompatibility(if you believe that 4-ACO-DMT is psychoactive on its own and not just a prodrug of psilocin.) It could still be interesting if it turns out to be a psilocin pro-drug, but your guess is as good as mine.

If I had to guess I'd say that this compound could be synthesized from psilocin and propanoic anhydride, but I'm not a real chemist so I have no idea what procedures that would involve or even if it would be possible.

I wanted to get some discussions on theoretical drugs rolling so please share your thoughts. Also could someone give me an idea of how to abbreviate this puppy? It's kind of tiresome to type 4-Propionoxy-N,N-Dimethyl Tryptamine every time. Lastly, feel free to discuss the other N alkylations with a 4-propionoxy substitution or even with a 4-Isobutionoxy-substitution(connect another carbon atom to that propionoxy group in the same place. Synthesized from psilocin and isobutyric anhydride). Really I would to like to hear what people have to say about them all but I didn't want to type them all out.

I will start at least a couple more threads about theoretical psychedelics during my time here at bluelight so check those out too if you like. This is my first post and let me say I look forward to discussing my favorite subject with you all!
 
Theoretical Psychedelics: 3,4-Dimethoxy-5-Ethoxy-Amphetamine

This drug was inspired by Meta Escaline. From what I read in PIHKAL Meta Escaline sounds like a psychedelic that has some fantastic properties. The only problem is that it's not very potent. I hope that an amphetamine homologue might provide similar effects, but at a smaller dosage. If this still does not bring the potency to an acceptable level, then perhaps we could try subbing those oxygens for sulfurs, first one at a time, then in combinations.

I would like to hear your thoughts on this particular compound. I am personally not as fond of phenethylamines as I am of tryptamines or lysergamides, but i think a few untested phenethylamines may still yet provide something excellent.
 
Theoretical Psychedelics: 6-Methallyloxy-6-Nor-Lysergic Acid Diethylamide - MAL-LAD

I call it MAL-LAD for short. I thought this might be worth looking into when I saw the difference in effects between Allylescaline and Methallylescaline. I have no idea what the effects would be or how this would compare to AL-LAD but if anyone has any thoughts, please share. I think that it might be worth exploring homologues of the most exciting research chemical to come out in the past few decades.
 
I've merged your 3 threads together so they can be shifted over to NAPD so it can be merged into the above linked thread :)
 
Hello, Brother Rico. I went ahead and merged your thread with this mega thread in NPD. You will find a lot of richly informed pharmacological speculation centered around varied rationale for novel compounds in here. Welcome to the site!

ebola
 
Brother Rico,

Your first one 4-propionyl-DMT will likely metabolize into psilocin just like psilocybin does, making them prodrugs of psilocin. However, 4-(n)-propyl-DMT is / would be quite stable. Below is its structure:

3-dimethylaminoethyl-4-propylindole.png


Or 4-(n)-propoxy-DMT if you'd rather:

3-dimethylaminoethyl-4-propoxyindole.png


Or even 3-dimethylaminoethyl-4-(1-oxopropyl)indole:

3-dimethylaminoethyl-4-(1-oxopropyl)indole.png


None of those 4-substituents are going anywhere fast, metabolically.
As for 3-ethoxy-4,5-dimethoxy-amphetamine, Idk but I hated escaline. And all methoxy-amphetamines are illegal in the U.S.
As for your MAL-LAD, I don't think di-N-substituted-O-alkyl groups are stable. In fact, I know they're not. However, if you lost the oxygen and instead ordered N6-CH(CH3)CH=CH2-LSD, then yeah that might work or would at least be makeable.

Also, you need to check out http://opsin.ch.cam.ac.uk and learn to draw out theses structures (provided you can name them) and post them here as .png's using the forumula: <IMG in brackets> http://opsin.ch.cam.ac.uk/opsin/(insert copy and pasted molecule name from the website you created there for it).png</IMG in brackets>. By brackets, I mean ['s and ]'s. Doing so will greatly help getting your point across and may help you weed out the impossible structures as well.

But anyway, I like your way of thought and encourage you to continue posting more here!
 
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Weinreb amides (N-methoxy-N-methylamides) must be stable compounds as they can be easily stored and are used on an industrial scale. Anyway, isn't MAL-LAD supposed to be just N-(2-methylpropen-2-yl)-nor-LSD?
 
Yes, well amides are one thing and amines another. Amides are much more stable, as the lone pair on electrons on the N feeds some of its electron density into the partially positively charged carbon of the amide. If you read my post carefully, you will see that I was referring to amines.

As for what he means by MAL-LAD, yes, you may very well be correct. Only he can tell us really. I just saw the methylallyloxy part and assumed he meant with an O there, which is just another reason it pays the theoretical chemist to invest some time in exploring http://opsin.ch.cam.ac.uk IMO.
 
I'm sure MAL-LAD is active (understood as adder says as: N-(2-methylpropen-2-yl)-nor-LSD). But considering BU-LAD, it is a good guess that anything more bulky than an allyl/propyl group on the 6 position on LSD is probably going to decrease potency by a lot. But who knows until it's made, right?

Another obvious one is iso-PRO-LAD. That is 6-isopropyl-nor-LSD. Any reason to not attempt a halogen on there too? Like chloro or bromo.....or flouro?

Shulgin made FLOURETH-LAD ( or talked about it theoretically at least) I guess FLOURMETH-LAD and FLOURPRO-LAD are obvious possibilities too, although the names sound totally asinine.

Why not slap the psychedelics counterpart to the emphatogens methylenedioxy ring; triflouromethyl, on there ---->6-triflouromethyl-nor-LSD, and get it over with, lol :)
 
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(5R,9R,13S,14S)-4,5α-epoxy-14-hydroxy-3-acetyl-17-phenylethylmorphinan-6-one

Can't figure out how to put the image of this on opsin onto here.
 
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roi said:
8-nitro-6-(pyridin-2-yl)-4H-benzo%5Bf%5D%5B1%2C2%2C4%5Dtriazolo%5B4%2C3-a%5D%5B1%2C4%5Ddiazepine.png


3%2C4-methylenedioxy-2%2C5-dimethoxyphenyl(piperidin-2-yl)methanone.png
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wtf i wanted to post exactly the same benzo as you last night as well as it´s thiobenzo variant =D

9mp9hxyc.png


jv353vu4.png


methamphetamine/methcathinone pro-drugs ? (edit: i forgot the 4-methyl at the cathinone)
 
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