I Like to Draw Pictures of Random Molecules

[roi]

^Start with 50ug and work your way up?

 

[pharmakos]

Not yet but it will be soon. There are 4 prototypes at the moment. Two displaying that orientation and two that are DOx. I am that guinea pig. I've been one many times before and this seems like it could be a boom or bust situation, plus it's already in transit and retailers are starting to get interested. If I don't then it could be a while to find another willing participant and even more time til it's on the market (if it's a boom then the sooner the better IMO).

Anyway I've always had a sort of...appeal to dangerous drugs (i.e MPPP, PMA, AFA (I actually coined this abbreviation, being the first to perform a full evaluation), Bromo etc) so guinea pigging is just another thing for me but this orientation, I just don't get. I'm sure there's no serious side effects as TMA-4 was pretty well handled, there are no real ties to neurotoxins like TMA-2 and it's attached to tea for christ's sakes but I just need to know if there is a slight chance it could turn sour.

If it looks all well and good then I'd still like to know just a little bit more about the compound from an advanced position, rather than my meagre pharmacological knowledge (I know the basics but I'm no chemist...yet!). Also it was designed by a fairly good chemist, unfortunately no information has been handed down to me apart from the IUPAC.

In all honesty I wasn't even planning on posting here, I was just going to titrate up and see what happened but it dawned on me that I need just a little background, apart from TMA-4 of course! The DOx are likely to be winners of course, also MDPEA-NBOMe is on the cards, although I wish it were TMDA or MDCBA (or TCB-MDA!). /That/ sounds very fun!

So, does anyone have advice?

yeah idk man, thats such a huge unknown. no in vitro binding data or anything? also, what do you mean by DOx prototypes? do you mean 2,4,5-orientation, but with a chlorine at the 2 or the 5 instead of the 4?

 

[blueberries]

Nah, I mean DOB and DOC (with the halogen at 4) but with the Xanthine attached (it''s basically Theophylline but with the upper amine on the pyrolle down one position next to the lower amine). It's a huge unknown, absolutely nothing but the IUPAC was given to me but first monkey and all, I enjoy this stuff and if it works it'll be the biggest mind fuck of the century!!

 

[pharmakos]

would you draw that for me?

 

[Str]

Sounds like some RH-34 analog?

 

[Nagelfar]

My "cyclomethiodrone (TCAT)" + "RRA-TMP (restricted rotational threo-MPH)" hybrid.

 

[roi]

Thiophene instead of phenyl would certainly make a interesting phenidate.

 

[Hammilton]

4 + 4 = 9
2 + 6 = 4
1 + 7 = 14

There's no real wrong way to get the right answer.

But there are an infinite number of ways to get the wrong answer.

 

[sekio]

i thought 5-chloro/5-bromo-MDA was known and active. so theoretically i'd expect the "5-iso-2c-c" compound type stuff to be active

as for the theophylline on the end... isn't that a feature of that one abused stimulant in the middle east? captagon or whatever? doesn't make me very nervous but it does suggest that it's gonna be less potent than a plan 2c compound

 

[roi]

https://en.wikipedia.org/wiki/Fenethylline

That one is around 25% converted to amph.

The DOB and DOC with the modified theophylline mentioned above:

Extended release DOx sounds rather shitty though.

 

[blueberries]

Damn, beat me to it! Well, here is the 2,3,5 in all it's glory.

I managed to get a bit more info on it too. It's an empathogen at around 100mg. The DOx are the same as roi's images. I imagine they will be psychedelic but ER DOx sounds not fun... They could be active close to 10mg based upon the above report but I'll start low anyway. The main thing is that the former is actually active! I'll have to explore higher doses to see if any psychedelia is present, but given there /is/ activity I'm much more hopeful than before!

EDIT: How did I not spot that Fenethylline?! I have it written down somewhere, just completely forgot about it. Also that 10mg was a complete guess, almost like I had a feeling it would be active there!! Weird. This could mean the 2,3,5 would be active at 25mg or so as an empathogen too though (without the theophylline). If it's a good quality empath then well, that'd be great!

 

[Soulfake]

Could this have any effects?

 

[pharmakos]

https://en.wikipedia.org/wiki/Fenethylline

That one is around 25% converted to amph.

The DOB and DOC with the modified theophylline mentioned above:

Extended release DOx sounds rather shitty though.

okay, yeah, i don't see the point of that stuff. maybe for DOB to skirt past the analogue act, but that's totally pointless for DOC. theophylline doses are significantly higher than DOx doses, so the theophylline probably won't have much of a pharmacological effect with these.

now, a theophylline ester of a phenethylamine/amphetamine that is active in the 100mg-300mg range would make more sense.

 

[Hammilton]

Strobamine, a weakish, but known DARI. Not sure if it's been assayed in humans yet.

 

[Dresden]

Discuss?

 

[roi]

 

[Nagelfar]

Strobamine, a weakish, but known DARI. Not sure if it's been assayed in humans yet.

Reminds me of the adamantane D1 agonist named 'A-77636' which "partially substituted" for cocaine in animal studies.

Not really close though, I suppose it's the cycloalkane in the middle connecting the boat formation; otherwise not very similar; just dopaminergic, and then not even in the same way.

 

[pharmakos]

hah. the adamantane theme here is not intended, just thought this up before i saw that post^

phenylcyclohexylamantadine

probably just silliness but its a funny thought

 

[Dresden]

This one looks great.

 

[Dresden]

Hell On Earth:

Plus, I know piperazines are usually neutral to crappy, but I can't resist suggesting these three:

And this presumably dissociative indole alkyl amine:

* * *

"Complications of a Mastermind.
Last temptation of my kind.
Extra-planetary sign, when do we align?
All in time."--The Red Hot Chili Peppers.