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I Like to Draw Pictures of Random Molecules

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@Roi and 2-MeO-2'-Oxo-PCMo

I´d rather have a go at the non-MeO, non-Oxo version. But I have absolutely nothing to base that on :D I still think I need to get me some of that 3-MeO-PCMo though.
 
Pyrophenidone (α-Phenyl-Pyrovalerone) works - I wonder what else would be tolerated.
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Roi, that's not the compound you drew, that's alpha-piperidinyl. It's an aminal (hydrolyses to 2 amines and an aldehyde)
 
I know. It was never my intention to draw Pyrophenidone, follow the link :O
 
Those fentanyl methylphenidate hybrids are very interesting, that way you could be charged with possessing an analogue of two controlled substances lol.
 
This is really a moot point, as if caught with any drug legal or not they will probably find you guilty anyway, but the analogue act only applies to Schedule I drugs. MPH is Schedule II, and thus, legally / technically anyway, the Analogue Act does not apply to its analogues.
 
sekio said:
from another thread
OYgXOTv.png
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I would add the nitrogen for where we need it to the MPH super-structure (as it seems a non-issue from similarly structured DRI analogs I've noticed) and remove the one oxygen also (which might pose a problem, but there are so many variants on the carbomethoxy part in DRIs that it's worth a go) to be closer to the fentanyl body. Methylfentidate perhaps?

U8Rll.jpg


The only real alteration is the extra nitrogen on the cyclohexane ring this way.

EDIT: I almost redacted my omission of the oxygen after looking at some fentanyl analogs (namely carfentanil and remifentanil) but then noticed it had the same omission in what would be the same place (the 2D images showing a true carbmethoxy type branch but in a slightly differing place which looked the same in a differing orientation from the WP images of the aforementioned compounds) they are universal in omitting the oxygen at that location (with alpha-methyl- shortening the adjacent branch and butyr- lengthening it, to an ethyl. But otherwise they're universally the same in terms of that oxygen)

I do know an oxygen at the 4′ position on the piperidine ring of MPH greatly hinders binding. Worse than enlarging the ring from a cyclohexane to something with more angles does. And of course, the methyl group on the carbmethoxy on cocaine and MPH is necessary for binding (i.e. cocaine is benzoyl-methyl-ecgonine, but benzoyl-ecgonine is not considered active, the same is true of ritalinic acid)

3-methylfentanyl has that methyl addition that seems conducive to both the binding properties of the DRIs and affinity to the mu GCPR.

Add that, and cross alfentanil with sufentanil, with the "methylphenidate" nitrogen, and add to the methyl on the carbmethoxy for my benzoyl-ecgonine rule being more functioning with the addition there like butyrylfentanyl to get this:

GuZJ1.jpg


(Being that the nitrogen is where the oxygen was that skewed the binding of MPH, we may be out of luck on this one, though I know they're completely different cases as binding is construed and unless the "phenyl ethyl tail" can work without it somehow)
 
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The N-CH-N moiety is known as an aminal & is unstable in presence of water usually. I have some doubts you'd be able to construct a 4-aminohexahydropyrimidine.
bLO8FTq.png

(water molecules not drawn)

Also, a ring with 4 nitrogens and 1 sulfur? 2,5-dihydro-1,2,3,4,5-thiatetrazole? You sir, are full of novel compounds that would make synthetic chemists sweat in their sleep. That particular ring is probably what is euphemistically referred to as an "energetic" material. (i.e. probably explosive)
 
Yeah that's one hell of a ring. I'd wager that it'd be explosive, so getting it on the rest of the molecule would be tough
 
sekio said:
Also, a ring with 4 nitrogens and 1 sulfur? 2,5-dihydro-1,2,3,4,5-thiatetrazole? You sir, are full of novel compounds that would make synthetic chemists sweat in their sleep. That particular ring is probably what is euphemistically referred to as an "energetic" material. (i.e. probably explosive)
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Hammilton said:
Yeah that's one hell of a ring. I'd wager that it'd be explosive, so getting it on the rest of the molecule would be tough
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I was thinking of the best way to get more "bang" out of it during onset. :-P
 
Nagelfar said:
Here, is this one better?:

jYTkI.jpg


Perhaps we should start looking at Tramadol analogs for this kind of thing.
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Geeze man some of your posts make total synthesis look not so bad. I mean this in an endearing way. Not this one in particular, but it's still really unlikely to be stable or synthetically attainable due to the amount of tautomerization possible.

PS try to say aminal fast without saying animal
 
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Congratulations Nagelfar, you managed to come up with a synthetically less accessible structure. Hexahydrophosphinines are hard enough to get to, there is absolutely no way you'd make that heteroatom-laden beast and keep it in a flask... (1,3-azaphosphinan-6-amine)

Alkyl phosphines are pretty firmly entrenched in the "Doesn't Play Nice With Others" camp. Not only in terms of their accessibility, but also odor, toxicology, susceptibility to oxidation etc.

Now, try a compound with a 4 membered carbon-polonium ring :P
 
sekio said:
Congratulations Nagelfar, you managed to come up with a synthetically less accessible structure. Hexahydrophosphinines are hard enough to get to, there is absolutely no way you'd make that heteroatom-laden beast and keep it in a flask... (1,3-azaphosphinan-6-amine)

Alkyl phosphines are pretty firmly entrenched in the "Doesn't Play Nice With Others" camp. Not only in terms of their accessibility, but also odor, toxicology, susceptibility to oxidation etc.

Now, try a compound with a 4 membered carbon-polonium ring :P
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The phosphine was, of course, a bit of a tease. Imagine a nitrogen there instead. :-P
 
You can't phosphine. You just can't phosphine. It's not allowed. You will never -- there is never -- you can't put a phosphine in a drug. Full stop. Instant covalently-bonding-to-enzymes territory, right there. Phosphonic acids, maybe. Phosphoric monoamide esters and N-phosphorylimines, sure.

Also, both of those aminals are unstable.
 
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