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I Like to Draw Pictures of Random Molecules

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that looks like some sort of peristent organic pollutant lol

someone needs to make one of the following: (nsfw for size)
NSFW:
6g7j2Wf.png


and more weird drug ideas
5j2dVEL.png


remacemide looks like a real weird drug! its metabolite is alpha-phenyl-amphetamine? and it's a dissociative???
 
Sekio, do you think that 2-Cl and 3-MeO Etoxadrol would overlay with ketamine and MXE in 3D? Or what is your reasoning behind that particular substituation?

Etoxadrol and Dexoxadrol are surely fascinating compounds :)
 
I read somewhere a while ago that Etoxadrol and its analogues have not so nice side effects. Maybe the morpholine analogues of PCP are the way to go (unless the potency is messed up as with 3-MeO-PCMo).
 
I read somewhere a while ago that Etoxadrol and its analogues have not so nice side effects
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I read that too, I think I recall it was discontinued because it caused nightmares in some. Oh no! A hallucinogen that induces dreaming. These were the studies published in '76 on 28 test people, I think only 2 of them didn't like it, and that's because someone megadosed one and he was fucked up for a week straight. Apparently it has a good tox profile, no major changes in chemistry were noted.

Doses were between below 0.75mg/kg (that was a typical anesthetic level) to 4.5 mg/kg (6-day fuckup) when administered IV, so between ~40 and 300mg. I bet it has good enough bioavailibility to be snorted or plugged though.

I also read etoxadrol is self-administered by monkeys just like cocaine or PCP. Dexoxadrol is also but not at the same frequency, it is negatively reinforcing.

So I want to see these being made availiable on the grey market! These are the dissociatives y'all want.

:)
 
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sekio said:
I read that too, I think I recall it was discontinued because it caused nightmares in some. Oh no! A hallucinogen that induces dreaming. These were the studies published in '76 on 28 test people, I think only 2 of them didn't like it, and that's because someone megadosed one and he was fucked up for a week straight. Apparently it has a good tox profile, no major changes in chemistry were noted.

Doses were between below 0.75mg/kg (that was a typical anesthetic level) to 4.5 mg/kg (6-day fuckup) when administered IV, so between ~40 and 300mg. I bet it has good enough bioavailibility to be snorted or plugged though.

I also read etoxadrol is self-administered by monkeys just like cocaine or PCP. Dexoxadrol is also but not at the same frequency, it is negatively reinforcing.

So I want to see these being made availiable on the grey market! These are the dissociatives y'all want.

:)
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I can't seem to find much information on etoxadrol beyond the (S,S,S) isomer. What is known of the other stereoisomers? Are they inactive or undesirable for other reasons?
 
J. Med. Chem. 1988, 31, 2257-2263
Synthesis, Absolute Configuration, and Molecular Modeling Study of Etoxadrol, a Potent Phencyclidine-like Agonist
doi: 10.1021/jm00120a004

TbUnXAp.png


I think they are inactive, they are orders of magnitude less potent as dissociatives that's for sure.
 
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sekio said:
that's the hope :D

i want another MXE type drug on the market!
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I hear ya :D

Another interesting line of research could be for enadoline analogs. Orally active k-Opioids, maybe not really promising as recreationals, but still very fascinating . I have no clue of the SAR though.
 
Sum stuff i wonder about:

Mesc_FLY_etc.gif


Inspired by the 2C-B-FLY that I just acquired =D

Note that the bottom right one has nothing to do with 'chlorine-washed poultry', but rather what the shape of the molecular formula is reminiscent of, as with the FLYs.
 
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Nice ones, Solipsis :) Especially the mescaline-dragonfly. I think it´s probably one of the few dragonfly´s I´d actually like to try, if the dosage turn out to be somewere between mescaline proper and BDFly. How it will be qualitatively is really difficult to imagine, I think.

The one I´d most like to have a stab at though, is TFMFly. Enjoy your 2C-B-Fly, btw :)
 
I'm interested in the effects of 2C-T-Fly actually, if only the toxicological effects in animals. I think 2C-T-X metabolism can be incredibly complex considering the big number of metabolites identified for one of them (I forgot which one). Constraining the methoxies should inhibit one of the metabolism avenues, like alpha-alkylation prevents another one. Then again preoccupying certain enzymes and the competition is not quite the same as eliminating a vulnerability in the molecule to metabolic attack at that position.
Anyway research on that could theoretically clarify what type of metabolites are more directly responsible for toxic effects or contraindications with toxic implications. That could help us to avoid certain 2C-T derivatives but not others.

Also... if a safe compound, it should make a fair middle ground regarding potency and duration considering 2C-T-FLY and SAR?

@ Mescaline-FLY, it might not be active at all... mescaline does seem to be a bit of an odd one in the mix, as proven by C30-NBOMe being inactive..

@ 4-Nitro-DMT and analogue cousins: what makes you say that there would be freak-out potential? I'd be really worried about the carcinogenic potential of nitroso metabolites and the like, especially aromatic nitro's are a really bad idea. Not quite sure what makes 2C-N or DON okay, the other substitutions perhaps offer enough steric protection to make those metabolic routes minor / slow compared to other ones.. Well fortunately I think DMT metabolism and perhaps also excretion somewhat is a specialty of the human body. :)
Would 4-Nitro-DMT be too polar to cross the BBB? At least the polarity would make it somewhat psilocin like rather than 4-MeO-xxT like.

Not sure but I thought 1-alkyl trypts or ergoloids were inactive. You would need an amide like N-valeryl I think?
 
Solipsis said:
@ Mescaline-FLY, it might not be active at all... mescaline does seem to be a bit of an odd one in the mix, as proven by C30-NBOMe being inactive.
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Yes, of cause. We wouldn't know until some one tried it. :)

Some interesting thoughts on 2C-T-Fly you have there. Hopefully we'll see some more new fly's available now that some one started making 2C-B-Fly again.
I'd say though, that going from my own 2 trials with it that I don't think that the fly-series compounds are going yield any new superdeep psyckedelics. 2C-B-Fly really is 50/50 a mild psyckedelic/mild empathogen.

Of cause I could be wrong.
 
Lol, 2CN and DON are not anymore ok than nitro tryptamines. It's the same type of thing, "Well, Shulgin invented this, so it must be safe," which makes people rail against chlorinated amphetamines but not DOC! As far as the nitro tryptamines go, I just figured that, due to the extreme electronegativity of the centrally located nitrogen atom (which carries with it a + charge), it would be even more freakout prone than high dose shrooms, which are hard enough to handle on their own. To my knowledge (which, granted, is quite limited), I don't think anyone has really made or tested indolic 1-N-pentyl tryptamines or 1-N-pentyl ergoloids. The indolic 1-N-pentyl group certainly works for many of the JWH's though! And for THC.

I would be truly afraid to try 5-nitro-tryptamine, I think. (I have never done 5-MeO-DMT, but I have read some badly ending trip reports here when it was being sold as an RC.)
 
Mescaline-FLY and Mescaline-hemi-FLY didn't fully substitute for LSD in rats even though they both had an increased affinity vs. mescaline for all subtypes especially for 5-HT2C. Both the FLY & the hemi-FLY analogues had a lower affinity at 5-HT2A but higher at 2B & 2C than escaline (source). However, escaline in this study also partially substituted for LSD.
 
Dresden said:
Lol, 2CN and DON are not anymore ok than nitro tryptamines. It's the same type of thing, "Well, Shulgin invented this, so it must be safe," which makes people rail against chlorinated amphetamines but not DOC! As far as the nitro tryptamines go, I just figured that, due to the extreme electronegativity of the centrally located nitrogen atom (which carries with it a + charge), it would be even more freakout prone than high dose shrooms, which are hard enough to handle on their own. To my knowledge (which, granted, is quite limited), I don't think anyone has really made or tested indolic 1-N-pentyl tryptamines or 1-N-pentyl ergoloids. The indolic 1-N-pentyl group certainly works for many of the JWH's though! And for THC.

I would be truly afraid to try 5-nitro-tryptamine, I think. (I have never done 5-MeO-DMT, but I have read some badly ending trip reports here when it was being sold as an RC.)
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Thanks adder!



No, DOC is not a serotonin releasing agent it acts in a pretty different way than haloamphetamines.. and I think that this particular toxicity is considered closely related to the pharmacological action.
As for 2C-N and DON... it matters whether metabolism of the nitro group is still a major pathway with all the other moieties in the molecule. That would determine the toxicity... so you are going on an assumption there.

Another assumption you make is that electronegativity of the 4-substitution in tryptamines is linear with the efficacy on the 5-HT2A receptor while the optimum may in fact lie more somewhere 'in the middle'. 5-Nitro would be more similar to bufotenin since the polarity is not shielded by an alkyl group.
Not that bufotenin and 'isomorphs' arent badass!

And 5-MeO-DMT instills a lot of awe in me, but has made me hardly anything but ecstatic and just plain 'beyond'... fortunately no terror, so psilocin remains more nightmarish for me. ;)
 
I have a feeling an etoxadrol synth could be on the cards, I'll find the literary material and pass it through but there needs to be a good backing for it to appear. I can do that also. I've wanted to try it since the first time I saw it, such a beautiful compound.

As potency is key, I devised this instead:

vijBVZq.png


However before all this goes through, I'd like some more insight on my earlier compounds such as 4-MeOH-DMT and that LSD/indole merger I created.
 
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