I Like to Draw Pictures of Random Molecules

[Midnight Sun]

hi all,

Got a few for y'all here... forgive the crudeness, chemdoodle kind of sucks

first on the list, o-trifluoromethaqualone:

call me crazy but I think it's the answer to the designer quinazolinone woes... CF3 being a proper bioisostere of CH3. As for all that fluorine electronegativity? I dunno what that'd do keep meaning to get a small batch of this one made but more important things keep happening


no idea what to really call this one... PCM?

not much to say here besides the 3-hydroxyphenyl & 3-methoxyphenyl substitutions also apply. I'm not really into arylcyclohexylamines lol


I'll throw the meph kids a bone here real quick

-- though I'm not too sure how well that whole arrangement would work out in practice. Fun to think about though


5-EtO-DOM:

kinda wonder why shulgin never looked into alpha-methyl homologues of the tweetios, if only to increase their potency a little


also:

and its -fly analogue, no idea what to call these either

I looked at this and saw a striking similarity to 4,5 MDO-DMT... I wonder if we could play amide musical chairs a bit here, if we lose the alkyl chain? would also be interested in a 5-hemifly version.

I have a couple others but maybe another time... hope these images aren't too oversize! I'll come back and just link them if so.

 

[Dresden]

Beta-carbomethoxy-a-pvp and beta-carbomethoxy-mdpv. These are ne/da reuptake inhibitors. The beta-carbomethoxy group works great on two other ndri's, methylphenidate and cocaine. Fruity delicious!

 

[Midnight Sun]

Beta-carbomethoxy-a-pvp and beta-carbomethoxy-mdpv. These are ne/da reuptake inhibitors. The beta-carbomethoxy group works great on two other ndri's, methylphenidate and cocaine. Fruity delicious!

I don't think that'd translate too well, from what I can tell the polarity induced by the beta-ketone is kind of needed on that basic skeleton... see prolintane for how drastically the drug changes without it.

not like the world needs any more craptastic chinese bathtub crank anyway... but if you insist, 3,4 dichloropyrovalerone

 

[DL-ark]

not like the world needs any more craptastic chinese bathtub crank anyway... but if you insist, 3,4 dichloropyrovalerone

Although I tend to agree, I read about such craptastic chinese bathtub crank being used way more than I could have possibly anticipated on bluelight. It seems that those who enjoy stimulants seem to really appreciate RC stims.

 

[Midnight Sun]

Although I tend to agree, I read about such craptastic chinese bathtub crank being used way more than I could have possibly anticipated on bluelight. It seems that those who enjoy stimulants seem to really appreciate RC stims.

Don't get me wrong, many RC stimulants are great in their own right - the fluoroamphetamines, x-apb come to mind, and now with phenmetrazine analogues coming online too. But all these x-pyrovalerones, and the rest of the "new gen" [dirt chemistry] cathinones can really go by the wayside as far as I'm concerned. Seeing what China is passing off as drugs these days is ludicrous.

 

[DL-ark]

Don't get me wrong, many RC stimulants are great in their own right - the fluoroamphetamines, x-apb come to mind, and now with phenmetrazine analogues coming online too. But all these x-pyrovalerones, and the rest of the "new gen" [dirt chemistry] cathinones can really go by the wayside as far as I'm concerned. Seeing what China is passing off as drugs these days is ludicrous.

Well, I don't have any sort of authority to discuss it anyway, seeing as I have never been one more stims (with an exception made for occasional amphetamine).

 

[pharmakos]

kinda wonder why shulgin never looked into alpha-methyl homologues of the tweetios, if only to increase their potency a little

perhaps out of concern that the duration would become unreasonably long

 

[Midnight Sun]

perhaps out of concern that the duration would become unreasonably long

naw, afaik he didn't ever look very far into the ethoxy subs, probably didn't really think much about it when so many greater options were on the table at the time

but yeah, duration would be a concern I suppose. Though for smart drug purposes, unless overstimulation is a problem across the proverbial dosage-board I wouldn't take much issue

 

[SkyblueMolly]

Here's one I just came up with.
It's cyclohexylpiracetam! %)

Here's 2C-2P, or 2,5-Dimethoxy-4-(2-Propyl)-phenethylamine. It already exist, but it's super rare and also called 2C-IP.

Here's Ethylcyclohexidate. It's based on ethylphenidate.

Here's amphemitalin.

Here's Betacyclohexylprolintane. It would be like a longer lasting prolintane.

The molecule, Memorimax. Based on ISRIB.

Stimvector. Based on Cyprodenate.

 

[DL-ark]

Maybe this would work well as a MAOI/opioid that could be very effective for highly treatment resistant depression.

either that, or poison.

 

[sekio]

looks like leonurine's bastard child with mppp

 

[DL-ark]

looks like leonurine's bastard child with mppp

Or tapentadol after falling into a vat of methyl radical

 

[SkyblueMolly]

1-Ethyl-1-Cyclohexanol (1E1C) active?

This page is to talk about 1-Ethyl-1-Cyclohexanol, or 1E1C for short. Since ECH(1-Ethynyl-1-Cyclohexanol) is active and 2m2bOH(2-methyl-2-butanol) and 2-Methyl-3-butyn-2-ol is active, 1-Ethyl-1-Cyclohexanol might be active.
1-Ethyl-1-Cyclohexanol might have a similar dose range to 1-Ethynyl-1-Cyclohexanol.
A picture of 1-Ethyl-1-Cyclohexanol (1E1C)

Does anyone have any reports on 1E1C? Has anyone tried 1E1C?
The melting point is about 35 degrees Celsius.

I wonder if 1E1CP is active.
Here's 1-Ethyl-1-CycloPentanol.

Any information on the effects of this compound?

Melting Point: -10°C
Boiling Point: 155-160°C

 

[Dresden]

3,4,5-trichlorophenylpiperazine dihydrochloride
3,4,5-tri-(MeS)phenylethanamine hydrochloride
3,4-di-(CF3)-methamphetamine hydrochloride
3,4,5-tri-(CF3)phenylethanamine hydrochloride
2,4,6-tri-(MeS)amphetamine hydrochloride
2,4,5-trimethylamphetamine hydrochloride

 

[SONN]

there are not too many people that I know of that have tried 1-ethynylcyclohexanol. some people claim its not very good for you but some people have enjoyed its effects. F&B did it a couple times and seemed to like it as he mentions in the other thread.

from another forum about ECH:

it would be a bad idea to co-ingest this with other substances (a good rule of thumb for any rc) as it fucks with your enzymes.

On another board I saw it called it a "extremely powerful self-catalyzed 'suicide' destructor of cytochrome p450" with a link to a study comparing it to the contraceptives norethidrone and norgestrel. i think this destructive power is due to the ethynyl group (which both contraceptives also have).

Propynylcyclohexane would probably avoid this problem and is also more potent.

Idk if that is true about ECH but I'm sure someone here does.

 

[Zeds(NCO2CH2CH3)2]

The above image is wrong it's 1-ethynyl cyclohexanol as sonn stated.

I HATE this stupid BS why the hell do people make terminal alkynes as attempted CNS depressants. These compounds are legit plasticizers they are UNDOUBTABLY carcinogens, let's alkylate our DNA shall we? Let's let cytochromes readily epoxidate this and get fking wrecked. And the quinone form is probably preferred, a suicide inhibitor of cytochrome id guess

NO TERMINAL ALKYNE DRUG are safe unless they are conjugated alkynes (couple cases of top drugs actually, even antifungal. These however cns depressant examples are so dangerous.

Please to anyone who reads this, DO NOT ingest these drugs.

 

[Solipsis]

Was the picture changed? Cause I'm seeing the 1-ethyl, no C triple bond C in sight... Seems that was intentional, and the OP is questioning the prospect on this alkyl analogue as an alternative.

Is the alkyne in ECH there as steric hindrance for alcohol dehydrogenase to protect against metabolism? If so couldn't the alkyne bond be substituted with say a halogen or some bioisostere that achieves the same but without the dangers Zedsdead mentioned? Cause the point might be that a simple alkyl isn't completely effective in achieving this, or maybe it is...

 

[yaesutom]

I would think 2 and 5 would be active.. probably 4 although it might screw with the body more (like bufotenin). Is there any reason divinyl tryptamines haven't been made? Its smaller than DALT.. and the DALT based ones aren't as psychedelic but maybe going down to vinyl would boost the psychedelia.

Is there a good reason why you shouldn't stick a halogen or other things up there like in 1?

5 might be good.. 4-aco-PiPT

 

[Dresden]

N-vinyl groups spontaneously exist in equilibrium with R-N=CH-CH3 which then reacts with H2O to produce R-NH2 + CH3-CH=O.

 

[Str]

What are your guesses on the trifluoromethyl derivative of mephedrone? It has more than a 3 times longer biological half-life and a very different metabolic fate. (link)

Would it, with its similar size be closer to mephedrone or would the electron density make the effects match those of 4-Cl-MC and 4-Br-MC?