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☮ Social ☮ PD Social Thread: N-Dimensional Funhouse of Possibilities

I wouldn't do it. MXP doesn't have any receptor affinity studies so besides NDMA antagonism, who knows what other things it touches. Plus aMT being a MAOI..... I also say slow your roll guy, there are many days to come! How old are you synth, if you don't mind me asking?
 
I personally would throw in the MXP (even though I've never tried it, lol) if the alleyscaline was feeling sorta bland.. But I'm reckless
 
I've seen some reports of health problems combining dissociatives and serotonin releasers. AMT is a serotonin releaser and MAOI, and MXP has unknown receptor affinities--but there's a good chance it hits a few different ones. A lot of the dissociatives I know of seem to have fairly promiscuous receptor binding.

Plus, you said yourself that you wouldn't touch MXP again for a long while. Hold yourself to that, dude. You can do it. At least wait for another day when AMT isn't involved--in my opinion that drug is definitely not meant for combinations.

Edit: btw, I've seen at least one study showing that the psychedelic phenethylamines function as dopamine releasers like their non-psychedelic counterpart--though of course to a lesser extent. I would personally be VERY nervous combining even allylescaline and AMT, considering the dosages you tend to indulge in.
 
laika my watch dog patrol is bleeping red!

thank you for the info @ fact, well if I'm here t minus 10 hours and still running i think some more brain damage won't hurt i think

tbh amt's whole maoi profile to me looks pretty negligible... i know mescaline is essentially related to dopamine but allyescaline seems to be quite fixated on the serotonin compound of things. mxp is NMDA/dopamine related, so it wouldn't be balancing it out per say, but surely on paper it looks safe-ish?
 
synthetix said:
laika my watch dog patrol is bleeping red!

thank you for the info @ fact, well if I'm here t minus 10 hours and still running i think some more brain damage won't hurt i think

tbh amt's whole maoi profile to me looks pretty negligible... i know mescaline is essentially related to dopamine but allyescaline seems to be quite fixated on the serotonin compound of things. mxp is NMDA/dopamine related, so it wouldn't be balancing it out per say, but surely on paper it looks safe-ish?
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I haven't tried amt--you might very well be right that it doesn't do much on the maoi side of things. However I've heard plenty of people claiming otherwise, and read of a number of people getting hurt on combinations with it.

MXP is of course an nmda antagonist. We don't know what else it touches. For example, 3-meo-pcp hits nmda and sigma pretty much exclusively (sigma probably causes the stimulation through down chain action), but dxm is a serotonin reuptake inhibitor, and ketamine touches... Mu opioid, kappa opioid, GABA, sodium and calcium channels, sigma, d2, and I'm sure others.

All of this is to say that dissociatives are fairly "dirty" drugs in terms of their binding affinities, and since we don't know all that much about MXP, it is in my opinion reckless to proceed with the assumption that it affects only nmda. I would most specifically be worried about the possibility that it is a serotonin releaser, since that could mean dangerous results in combination with amt.

However, you'll probably be fine. It's not that I think a dangerous interaction is likely, just that I don't think we can reasonably say it's unlikely.

Best of luck to you, man. Have fun.
 
InterestingFACT, if you don't mind me asking, how do you know all of that? Have you studied chemistry? I'm not trying to sound like a smartass, I'm genuinely curious!
 
my understanding of mxp was that it acted on NMDA, sigma, and dopamine (DRI) and dopamine is a pretty one we can kind of mess around with, more so than serotonin no?

if it was MXE i'd be reconsidering it...
 
The MAOI issue wouldn't be the only problem... AMT is releaser and reuptake inhibitor of pretty much all monoamines, can be too much of dissociatives like MXE or diph / MXP also interact with transporters.
Don't combine AMT with dissos unless maybe K! plze gooby
 
but i so want to experience the weirdness again..... would it really be that unsafe?

its literally been 12 hours since i took the amt

christ.... time fucking flew by!?
 
Less than 3 weeks til the Lock'n Festival! I am so fucking excited, it's like Christmas when I was a kid!

Then the very next weekend, FarmAid is in Raleigh which is close enough to drive... Neil Young, etc. Lots of other great ones but I REALLY want to see Neil Young. Not sure if I'll go but the tickets start at like $50. But the very next weekend after a 4-day festival... man, that will be intense.

I have a long, intense day at work. Took 4mg of sunifiram, a bit of phenibut, and one single toke of weed. Should be a nice boost. :) Work is so much easier when it doesn't feel like pulling teeth. I've had work motivation problems this summer because all I want to be doing is being out, living life, doing awesome shit. I get it done... but it sometimes feels torturous.

EDIT: I think sunifiram might make weed feel extra good. I noticed it yesterday and today when I took a hit right after the sunifiram hit me. Interesting...
 
haha just plugged MXE for the first time, 20mg working quite nicely heh. First time plugging anything and I think I got it right, hehe
 
Yeah plugged MXE is much stronger, it will get deep on you faster too.

Yeah a-PVP sounds pretty gross. I've gotten a sample 2-FMA recently, with my MXE and methylone (for the festival, well I might do some MXE before then =D). I'll try it soon I think, sounds nice.
 
dstr8427 said:
InterestingFACT, if you don't mind me asking, how do you know all of that? Have you studied chemistry? I'm not trying to sound like a smartass, I'm genuinely curious!
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Wikipedia! Well, not so much Wikipedia as journal articles--you can do searches on pubmed for abstracts, and if you have a university or local library you can get most of that stuff for free. Otherwise, I believe there's a thread on blue for requesting journal articles from people who have more access.

I'm an undergraduate neuroscience major, but of course they aren't talking about novel drugs of abuse very often in class.

Xorkoth said:
Less than 3 weeks til the Lock'n Festival! I am so fucking excited, it's like Christmas when I was a kid!

Then the very next weekend, FarmAid is in Raleigh which is close enough to drive... Neil Young, etc. Lots of other great ones but I REALLY want to see Neil Young. Not sure if I'll go but the tickets start at like $50. But the very next weekend after a 4-day festival... man, that will be intense.

I have a long, intense day at work. Took 4mg of sunifiram, a bit of phenibut, and one single toke of weed. Should be a nice boost. :) Work is so much easier when it doesn't feel like pulling teeth. I've had work motivation problems this summer because all I want to be doing is being out, living life, doing awesome shit. I get it done... but it sometimes feels torturous.

EDIT: I think sunifiram might make weed feel extra good. I noticed it yesterday and today when I took a hit right after the sunifiram hit me. Interesting...
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I can relate so much to that. I get hyper focused on activities that I find "interesting" at the moment, and it becomes so difficult to plow through other things, like work.

It doesn't surprise me at all that sunifiram and weed interact. People say that noopept, piracetam, etc modify a weed high as well, if I remember correctly. But sunifiram increases AMPA channel opening frequency--and AMPA is the most common glutamate receptor, and glutamate is by far the most common excitatory neurotransmitter in your brain. This is why I'm careful about combining sunifiram with stimulants or psychedelics--almost any other receptor type will cause down-chain glutamate activity. By amplifying glutamate signaling, sunifiram would probably amplify the effects of other drugs.

All of this is just bullshit I'm making up, course. Anecdotally, however, sunifiram seems to hugely potentiate psychedelics for me. (For example, about a month ago I basically tripped nuts off of 2mg 5-meo-mipt combined with some sunifiram.)

Also 2-fma is super awesome, in my opinion. It's really a drug that lives up to the claims made about it on the internet, which is pretty awesome. Calm focus for hours, unobtrusive, incredibly free of side effects. Highly motivating, with some mood lift, but no euphoria. I've seen it claimed that 2-fma is the best ADHD drug in the world, and I'm inclined to agree with that claim. It's just a shame about the cardio toxicity concerns with it: I can't in good conscience consider it as a long term replacement for my vyvanse for that reason.

Also I recently read a study which claimed that the fluoro-amphetamines actually are metabolized moreso by the body than regular amp. I'll have to go see if I can dig it up.
 
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