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I Like to Draw Pictures of Random Molecules

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sk9q7O0.png

Should have put an extra methoxy on tp2c, the way its drawn up now its probably inactive as a psychedelic, perhaps it may be a histamine agonist or other psychostimulant.
Chlorophenbarbamide felt too obvious as an interesting idea. I doubt however it is useful or even safe for abuse. It may make more an excellent dual action anesthetic.
Next to that I've made a funny looking molecule. Look closely and you'll see the inspiration for it. I have no idea what sort of activity it might have, perhaps opioid, perhaps nmda, perhaps even 5-ht2a.
Next one is a compound which should be serotoninergic and could have opioid activity similar to ibogaine.


The rest im sure look silly to more versed members but I have made these with the intention of these being active in some way.

oh also chlorophenbarbamide is missing the amide on that other side of the ketone to make it barbituric acid.
 
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May I please ask, if you have no idea about chemistry, can you just make something and use it on yourself?
 
Tim3 said:
May I please ask, if you have no idea about chemistry, can you just make something and use it on yourself?
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To make it you would have some ideas about chemistry in the first place unless you are doing something simple and shady like heroin from morphine.
 
May I please ask, if you have no idea about chemistry, can you just make something and use it on yourself?
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No, no you can't, depending on your definition of "make", eg, you could likely easily synthesize freebase cocaine from cocaine hcl. ;)

ebola
 
You can eat dirt from your front yard if you want, there's nothing stopping you but common sense and social mores. So yes, you can make whatever drug or chemical you want and eat it if you so choose. It's just that generally that's a mighty risk that could land you in the hospital at best and a grave at worst. Such is the reason Shulgin has his titration up from nanograms.

People generally stick to making closely related derivatives of chemicals that have known activity first, and then test them in cell culture or animal models to make sure they aren't acute toxins,l before human ingestion takes place. The lucky few make compounds (or close analogs_ that have already been tested in biological systems and usually have already been patented for some use (mephedrone, MXE, JWH analogs), so the hard work is done first by someone else and they reap the profit.

(either way - Tim is banned because he's not very creative as an alt account of a known spammer/shit poster. So sorry, Tim, but we don't need to put up with your shit. The mystery NDRI you take is not good for you.)
 
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A nice, simple one for you all. A ring-opened morphinan analogue. Because of the ring-opening it should bypass the analogue clauses of many countries because they specifically refer to morphinan analogues, which, since the 4th ring is opened, this is not. It is merely a bizarre phenanthrene, which is outside the scope of the legislation, in my country and others. The morpholine ring was just the first thing that came to mind, that also helped to further distance it from its parent compound. It could just as easily be replaced by an n,n-dimethyl, n-methyl-n-phenethyl, or whatever else the mind desires. Thoughts?

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SeenSoFar said:
A nice, simple one for you all. A ring-opened morphinan analogue. Because of the ring-opening it should bypass the analogue clauses of many countries because they specifically refer to morphinan analogues, which, since the 4th ring is opened, this is not. It is merely a bizarre phenanthrene, which is outside the scope of the legislation, in my country and others. The morpholine ring was just the first thing that came to mind, that also helped to further distance it from its parent compound. It could just as easily be replaced by an n,n-dimethyl, n-methyl-n-phenethyl, or whatever else the mind desires. Thoughts?

download.png
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That looks really good, and it gave me an idea for novel opioid:

t5cGYuE.png

The NBOME series has a very high affinity for mu-opioid, but since it has like 20x higher affinity for 5-ht2a, one doesn't feel it. It shows that a structure like this could be possible for mu opioid affinity.
 
I love your thinking! I was toying around with putting one there as I do love the 'ol fluoros but I decided to stick with a methyl to set a baseline. Any idea what the effects or even just potency would be like? I've not seen anything like it before, but it must have been thought of, no?
 
Another quick one for you all. This one is for sure outside the scope of most every analogue clause it there, and almost sure to be a very powerful μ-opioid agonist. I would really like to take this one for a spin, I'd bet it would be fantastic! Any thoughts?

download1.png
 
black53 said:
I'd put a F there, it's about the same size as a hydrogen, the methyl is imo too big.
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You could always dideuterate it? Then again it wouldn't really do much in terms of effects. Hydroxy? Or even an amine?

How about 2 fluorines on the IAP skeleton?! Or actually the bottom one would be a fluorine then the top a methoxy to form the broken ring.
 
SeenSoFar said:
Another quick one for you all. This one is for sure outside the scope of most every analogue clause it there, and almost sure to be a very powerful μ-opioid agonist. I would really like to take this one for a spin, I'd bet it would be fantastic! Any thoughts?

download1.png
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Maybe another hydroxy? Either on the phenyl or the piperidine?
 
blueberries said:
You could always dideuterate it? Then again it wouldn't really do much in terms of effects. Hydroxy? Or even an amine?

How about 2 fluorines on the IAP skeleton?! Or actually the bottom one would be a fluorine then the top a methoxy to form the broken ring.
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Hydroxy might hurt the BA I believe. But, maybe you could use an acetyl group, which will metabolize to hydroxy like 4-aco-dmt or heroin?

Like this:
yGYDPwF.png


What about something like this?
mGYM4U4.png
 
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SeenSoFar said:
Another quick one for you all. This one is for sure outside the scope of most every analogue clause it there, and almost sure to be a very powerful μ-opioid agonist. I would really like to take this one for a spin, I'd bet it would be fantastic! Any thoughts?

download1.png
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Why do you think it would be an opioid? I bet it's not an opioid at all or a very very weak one at best, the nitrogen is differently orientated in relation to the aromatic ring than in morphinans and related opioids. No matter how you rotate it, the nitrogen seems to be too far away and the additional bulk doesn't bode well either. Keeping all that in mind, it wouldn't pay off to do the synthesis, which would be quite complicated.

Cheers!
 
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adder said:
Why do you think it would be an opioid? I bet it's not an opioid at all or a very very weak one at best, the nitrogen is differently orientated in relation to the aromatic ring than in morphinans and related opioids. No matter how you rotate it, the nitrogen seems to be too far away and the additional bulk doesn't bode well either. Keeping all that in mind, it wouldn't pay off to do the synthesis, which would be quite complicated.

Cheers!
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Well, in 3D it actually overlays extremely closely with both morphian and phenylpiperidine opioids. As for extra bulk, the N-Phenethyl substitution actually works to increase potency quite well in most every opioid. I would venture a guess that it would be extremely potent.
 
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