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I Like to Draw Pictures of Random Molecules

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Oh goody, after flephedrone, now fladrafinil - I was just thinking the other day: we need more drugs that sound like Daffy Duck came up with em.

SBM, any reason you didn't include the more obvious one?:

Constrained_modafinil.jpg
 
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Solipsis said:
Oh goody, after flephedrone, now fladrafinil - I was just thinking the other day: we need more drugs that sound like Daffy Duck came up with em.

SBM, any reason you didn't include the more obvious one?:

Constrained_modafinil.jpg
Click to expand...

Which obvious one? That molecule looks like N-methyl-insomfinil.

This molecule is Ecstatrion.
34j3se1.png

This molecule is EGHQE-D, or 4-Methoxy-(Ethyleneglycolyl-hydroquinone-ether)-1-Ethylamine.
1zew5yd.png

The eugerioc(wakefulness enhancer), 2C-G-N. 2C-NAP, 2C-NAP-H, or 2,5-dimethoxy-naphthylethylamine. It exist already. It's only posted so you can see where the next molecule came from.
30sdld5.png

This molecule is 2C-Naplock. What if you can stay up for over 80 hours with this. Or the longest anyone has ever stayed up, which is i don't know. Could it make you stay up for 30 to over 110 hours?!
mt9esl.png

3C-Naplock.
15yu0lf.png

4TC-Naplock. Maybe it'll cause someone to stay up from 35 to over 200 hours. 200HOURS!!! They'll DIE INSTANTLY! 8o :) :D XD
axzm0o.png

Maybe the 4TC-x series of compounds may carry most of the nootropic effects of the 2C-x series, but almost none of the psychedelic effects. The series might be more empathogenic/entactogenic and euphoric at higer doses though. Who knows?
2exog8g.png

Here's Nortametraline. Nor means it doesn't have the N-methyl substituent like tametraline does. Since it's likely a norepinephrine/dopamine reuptake inhibitor, and not just a dopamine reuptake inhibitor, it's likely to retain it's stimulant strength while being less addictive. Like a safer, cleaner version of ritalin with less dependance and less damage.
of6iqp.png

Megalert is like tametraline on steroids. It might cause so much stimultion, you'll stim to another dimention. Hahaha!
30wwo40.png

This is ultericrash!. Ultericrash! would be crazy. /!\Warning: Extreme stimilation! The exclamation point is totally nessesary. Ultericrash!
2q9b9g5.png

This might be the cooler series. 2C-x-N1C-x serieses. Cooler than N-bomes! Starting with 2C-x-N1C-D series.
this is 2C-I-N1C-D.
1zd0u12.png

This is 2C-Ph-N1C-D.
kaw7q.png

Here's 2C-Ph-N1C-NAP.
28wpjy0.png

There are hundreds of possibilities with the 2C-x-N1C-x serieses.
 
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I find the names annoying. Were I someone who was doing actual research and actually tested one of these compounds, I'd want to have naming rights, but instead someone's gonna go online and be like, haha douche, some guy on Bluelight beat you to it!
 
^ what's it gonna do? make the physical side effects even more pronouned than the non-beta-keto version?


since we're talking about fluorinated things:
2hnno0l.png

those fluorine atoms should fit nicely into serotonin releaser SAR (after all fenfluoramine also does with that 3-trifluoromethyl group). cardiac fibrosis shouldn't be a problem with sporadic use (at least not more than with the APBs). there's also a lot of room for variation in the number or flourine atoms (from one to all four positions indicated) and also with the stereochemistry. i'd definitely be interested in receptor binding studies and would imagine some of those variants to be fun.
 
Ebola, I noticed you killed a bunch of people in Guinea... what's up with that man?
 
Just some doodles.

HwxXLiY.png


I also recently saw this paper detailing some CNS active carboranes (and other funny shapes.)
8RLHNtW.png


So, why not carborane-JWH? (actually, carborane-AM2201) It should be promising given what we know about SAR at the cannabinoid receptors.
EIHXXdM.png
 
iamthesuck said:
DISCLAIMER: i know didly about chemistry past a college 100 level

http://tinypic.com/r/1puxx0/8

edit: trying to post an image, link works
Click to expand...

iamthesuck said:
Another between classes. someone PM me w/ help to get the images up?
http://tinypic.com/r/xgfnkh/8
Click to expand...

just copy the "IMG code for forums and message boards" field from the bottom left of the tinypic page, like so:

1puxx0.jpg


xgfnkh.jpg


you can also click "quote" on my post to see the code.

sekio said:
So, why not carborane-JWH? (actually, carborane-AM2201) It should be promising given what we know about SAR at the cannabinoid receptors.
EIHXXdM.png
Click to expand...

dammit sekio, i hope the synthesis for this is pretty difficult, otherwise we're going to see it available from china in about a week
 
1znlufs.png


2u4il5l.png


34ox2qd.png



Ergoloids, I think they might be active. I have no clue, but 5/6 of the ones I posted I would actually expect something from.

Now, I picked phosphorus to change it up, but theoretically nitrogen could be used there as well
 
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some good possibilities there ^




here's one because i'm feeling silly and i kind of miss shaggyfin's hybrid molecules idea =p

znr8u1.png


i'm almost certain i messed up some of the bonds.
 
yXjqPE7.jpg


I call it hormonal-girlfriendamine.

EDIT: I tried to make the amine Nitrogen Oxide but Marvin said 'N-OH'
 
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I was recently wondering if the thianapthene derivative of 5-APB might be of any interest. From a synthetic perspective, thianapthene is a very different animal than benzofuran. However, I don't have nearly enough biochemistry/related experience to even guess to how this would carry over in terms of pharmacology.
 
So, here is another big batch of randomness from me. The motivations for these are all relatively straightforward. Compounds 1-4 are all variations on applying the phenmetrazine SAR to tryptamines, God only knows how well that will work. Compounds 5-10 are all different ring constraints applied to the tryptamine backbone, a-la aminoindane and aminotetralin compounds. In addition, compounds 9 and 10 are an attempt to make a tryptamine homologue of lorcaserin. The basic tryptamine ring and N- substituents could be applied to any of these, and they have been labeled as such where applicable.

I would be interested in sampling any of these compounds, as I am sure that most would have some level of interesting pharmacological activity. It would be interesting to know if the aminoindane/aminotetralin-esque compounds would end up being SSRAs like their phenethylamine counterparts, or if something totally unexpected would happen. I'm sure eventually we'll find out for many of these, since most are not too far out and are at least VAGUELY grounded in some sort of SAR.

Comments?

2ec29fbd-1ec6-4ed3-a34e-5cfa6253eac2.png
 
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