I now have a little bit of direct experience using 25-i-NBOH,
albeit from a different vendor than my NBOME supply,
and I have to admit that I have more appreciation for the NBOH version
however
my tiny NBOH blotters have 1200 mics, and my largest (titration) dose so far has been 1/2 tab, or 600 mics (according to vendor).
AND
my larger (normal blotter size) NBOME blotters have 1000 mics, my largest dose has been 1/2 tab, or 500 mics (according to vendor).
I think it is more than just the size of the blotter (i.e. being incredibly small -> spiffy -> modern);
I think the NBOH is less tweaky and just a bit more magical. (more audio halucination, more CEV, more OEV, more synaesthesia),
and more ability to snap back to act normal/straight, and then trip out
- which is a wonderful freedom to discover - almost the essence of my whole consciousness project altogether.
As for tolerance, more than 48 hours without any psychedelic permits a good effect for my titration so far; less time between is a waste of the research material.