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Novel (realistic) Antidepressants

I read that one looking for info about this actually. I wish they would have looked at behavioral measures too. They may be flawed, but they're better than nothing. The measures they look at don't seem useful to me for looking for antidepressant effects.
 
Agreed. However Hammilton, I think we both know that when the temperature in your rectum is raised, you must be happy because I would be inside of you.

I can't think of any proper reason as to why tramadol would be any better an antidepressant than venlafaxine, as the opioid component is so weak that I personally can't even feel it (unfortunately huge tolerance), UNLESS, it has some other separate mechanism of action such as delta opioid agonism etc.
 
you could maybe try low dose daily ibogaine like 20/50mg a day.
No chemical is magic,the more you chase chem happiness the more it runs away, however ibogaine is the best of the best of the best!!!!
it works on a neurological level but it also brings to consciousness all the psychological issues that underlie the depression, all other antidepressant suppress you true feelings making long term healing harder,
ibogaine makes it easier.. anyway YOU have to step the step ;)
 
Scopolamine is being investigated for its antidepressant properties as well:

http://www.ncbi.nlm.nih.gov/pubmed/23146150

I haven't tried MAOIs myself, but many swear by them when nothing else works. I hear the transdermal selegiline (Emsam patch) version doesn't have a tyramine-restricted diet, and will probably be the next one I try, if I can afford it.

I finished and tossed my empty bottle of Elavil (amitriptyline) earlier today. I didn't notice anything on it (or on imipramine), except that it tasted a little weird. I was surprised by the number of drugs listed in this thread I haven't heard about or tried, considering I've tried 20+ over the years. This was also a little disheartening, as I see many more failed drug trials (along with their quirky side effects) in my future.
 
ektor said:
you could maybe try low dose daily ibogaine like 20/50mg a day.
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Why would one want to take ibogaine daily?

arctica said:
I hear the transdermal selegiline (Emsam patch) version doesn't have a tyramine-restricted diet, and will probably be the next one I try, if I can afford it.
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At lower doses, selegiline remains selective for MAOB over MAOA, and it's MAOA that breaks down tyramine. However, it's my understanding that the dosage on the patches is pretty high, so you should check to make sure that it retains selectivity.

ebola
 
ebola? said:
At lower doses, selegiline remains selective for MAOB over MAOA, and it's MAOA that breaks down tyramine. However, it's my understanding that the dosage on the patches is pretty high, so you should check to make sure that it retains selectivity.
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Only the 6mg/24 hour patch has no dietary restrictions, the 9 and 12 have the standard dietary restrictions.

Approved medication guide: http://www.fda.gov/downloads/Drugs/DrugSafety/ucm088589.pdf
 
i find daily cannabis use to be quite anti-depressant and i've had terrible depression in the past and although not diagnosed, i was thought to suffer from borderline as well. official diagnoses are epilepsy, adhd, dysthymia, and anxiety NOS.

meds i'm currently taking: diazepam 20 mg split in 2 doses.

i've been on SSRI's, memantine, antipsychotics, other benzo's, and methylphenidate but the winner for me was diazepam, WHEN NOT ABUSED. every time i abused a benzo in the past my depression became worse.

anyone ever wondered what it'd be like to be on a daily psychedelic regimen for depression??? imagine taking lsd in two split doses daily under supervision until enough tolerance develops to the hallucinogenic effects? then keep taking it daily??
 
also, wellbutrin seemed to be wonderful for depression, it didn't feel dopaminergic at all. it was like on a class of its own, but it's too expensive.

wellbutrin's antinicotinic properties seem interesting.
 
Dextromethorphan is far more interesting for both depression and its nicotinic acetylcholine antagonism than bupropion is. Bupropion is about as worthless as buspirone for anything but ameliorating anorgasmia and other erectile dysfunction brought on by SSRIs.

Its great if you want dirty speed though. :\

AMT is a psychedelic that has antidepressant properties - its actually the most effective antidepressant I've ever had. I would have a hard time taking anything that feels as good as AMT does in a non-recreational dose though (I'm sure most would agree with me about self control regarding a substance that makes you feel fantastic otherwise we wouldn't be here on Bluelight if we didn't have our drug of choice) and I actually found low doses of AMT to be extremely uncomfortable (including the 5 and 10mg doses that they used to prescribe).
 
Lopez said:
also, wellbutrin seemed to be wonderful for depression, it didn't feel dopaminergic at all. it was like on a class of its own, but it's too expensive.

wellbutrin's antinicotinic properties seem interesting.
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I've noticed that I spend less money on Wellbutrin, specifically, less money on small, anxiety-related purchases like another _____ just in case I'm out.

Also, small self-soothing purchases, like a lip balm I surely don't need because I have 400 at home, but suddenly it seems really important to buy lip balm. When I'm on Wellbutrin, I don't make those purchases. I have a suspicion that Wellbutrin would be very effective for people with shopping addictions.

ETA: the problem I've always had is that I seem to get a true antidepressant and anti-anxiety effect from Wellbutrin, but it's mild. It bumps my mood up a notch, my anxiety down a notch, very well-tolerated. But! it just can't get enough traction to pull me out of a major depressive episode, even at doses up to 450 mg. It doesn't seem like increasing the dose of this drug increases its (beneficial) effects. Does anyone know why that is?
 
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Been through all the old school and new AD's, but keep coming back to Remeron 50 mg. Only one that I found that works and doest quit working all of the sudden after a short period of time!
 
I usually use a combination of SAMe, Tianeptine, Curcumin extract + dark chocolate, Resveratrol and Inositol. If I'm really depressed I add a small amount of Moclobemide.
 
Kanna has pretty pronounced antidepressant effects honestly. I only used it a few times but it really made me wonder if a chemical extraction of the active components would be a good treatment for depression seeing as it's the worlds only natural SSRI. I also bet smoking some of the fresh plant would be pretty pleasant. The active ingredients could also have alterations to their structures to make synthetic antidepressants better than a lot of the ones we have now
 
Quercetin has been on my mind a bit lately. It's not absorbed when taken orally (the molecule hydrolyses at stomach pH), but it has an EC50 that indicates it'd be about 1% as potent as selegiline as a MAO-B inhibitor, except it's reversible. I looked into it, but the quercetin available from the "supplement" stores[1] near me contains calcium carbonate, which isn't something I want on my mucus membranes.

'course, I'm pretty sure I'm more curious than depressed.

[1]: Such stores are basically rip-off emporiums, and some things they sell (potassium supplements D: ) can be dangerous. I'd suggest not shopping there.
 
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