• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Novel (realistic) Antidepressants

do you guys actually think 'anti-depressants' work? I think they are total and complete BS. The only real anti-depressants are all illegal, lol go figure.
 
JahRed24x said:
do you guys actually think 'anti-depressants' work? I think they are total and complete BS. The only real anti-depressants are all illegal, lol go figure.
Click to expand...

From what I have noticed, this is a common opinion of many drug users. I have seen them work for non drug users (and a very small amount of drug users). Go figure. For me, they are total and complete BS.

[name redacted], you mentioned in another thread that you were once on Nardil and it was bliss. Why did you quit taking it then?
 
Last edited by a moderator:
^ Interesting, I really only have tried the SSRIS, and selegiline which actually works quite well for me, so I can only assume that phenelzine would top it.

I have to make the decision next week between going on methylphenidate for my ADHD or phenelzine or my depression/anxiety, cause obviously my psych wouldn't put me on both. I have no idea which I should choose at the moment.. bah. Because it has taken me a lot of effort to get the methylphenidate, had to get opinions from 2 psychiatrists because of my past history of drug abuse. What do you recommend?
 
permastoned said:
^ Interesting, I really only have tried the SSRIS, and selegiline which actually works quite well for me, so I can only assume that phenelzine would top it.

I have to make the decision next week between going on methylphenidate for my ADHD or phenelzine or my depression/anxiety, cause obviously my psych wouldn't put me on both. I have no idea which I should choose at the moment.. bah. Because it has taken me a lot of effort to get the methylphenidate, had to get opinions from 2 psychiatrists because of my past history of drug abuse. What do you recommend?
Click to expand...
I would most definitely go with the Phenelzine. You will be much better off in the long run.
 
Selegiline is not even that good. People see that it elevates dopamine and they automatically think they will like it.

That is just prejudice because if you actually try the stuff you will see how it isnt really good at all.
 
Iv seen excelent results from SSRI's from my friends that use it (all drug users) and Avanza.
 
I still think NMDA antagonists are the way to go. They exert their antidepressant effects in the first few hours of use, and then continue on. Problem is, they're all too much fun, so the government won't let us have them yet :p
 
JahRed24x said:
do you guys actually think 'anti-depressants' work? I think they are total and complete BS. The only real anti-depressants are all illegal, lol go figure.
Click to expand...

they definately can help. It really all depends on finding the right combo. But once you find it they can really help. Bupropion has tremendously lessened my cravings for stimulants.
 
Someone suggested Periactin (Cyproheptadine). Not a good idea as it's antiserotonergic.

Made me extremely depressed while taking it for sleep problems with escitalopram
 
Someone suggested Periactin (Cyproheptadine). Not a good idea as it's antiserotonergic.
Click to expand...

The 5-ht2a antagonism might be an issue in some, but 5-ht2c antagonism has disinhibiting effects on certain parts of the brain and is linked with some antidepressant efficacy.
 
is Cyproheptadine still widely used? it has some interesting effects in rats and other critters on the insulin producing beta cells.
 
THANKING ANY MOD WHO CAN BRING THIS TO ATTN OF REIMANN ZETA. UNABLE TO PM

Hi,

I am assuming you are in the UK -I read in your posts about how you take dexedrine. How can I ask did you manage that one? I've had TRD for about 7 years, been on 20+ medications+ currently doing 'ok' on a cocktail of high-dose bupropion, effexor and clonazepam.

The benefits are modest. I'm sure since d-amphetamines are not genuine antidepressants, they rarely play the position as 'workhorses' of theraputic regimens, but I am intrigued to know how they affect your daily mood/coping abilities. And also whether tolerance/ receptor downregulation compromise long-term effctiveness?

I am looking more and more into pstims for augmentation (I did try modafinil once with some success, but found it had a bad cumulative effect of sleep and its positive effects on mood disappeared after a month)

Apologies for the mini-essay. Questions answerable at your convenience. Thanks very much,

Kflux
 
^ Definately. Best AD i've ever encountered. Been on it for a very long time and still works great.
 
Sturnam said:
I still think NMDA antagonists are the way to go. They exert their antidepressant effects in the first few hours of use, and then continue on. Problem is, they're all too much fun, so the government won't let us have them yet :p
Click to expand...

Yeah, I've always wanted to try Memantine. I could be wrong, but I don't think there is a whole lot of abuse potential with it. Maybe I'll ask my Psychiatrist if he'd prescribe it as an add-on to the Parnate, Suboxone, and Lyrica I'm currently taking. I don't think that it would be a problem with an MAOI.
 
Tsukasa said:
^ Definately. Best AD i've ever encountered. Been on it for a very long time and still works great.
Click to expand...

Yeah, but you just admitted to being addicted to it and said that you planned on living only a short while longer in the same post. Not exactly a vote of confidence, huh?
 
You must log in or register to reply here.
Top