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Novel (realistic) Antidepressants

Duloxetin weakkly blocks the Dopamin Transporter ( 240nm;0.8nm SERT,7.5nm NET) and inhibits DA uptake,maybe its sufficient clinically,at least it appears quite effective (personal experience,but f*** the withdrawal)

http://www.nature.com/npp/journal/v25/n6/full/1395741a.html

Desvenlafaxine (Pristiq) will come to market soon,but it appears more a patent related thing.Venlafaxine is still a bit a mystery to me,not really a SNRI,rather a SSRI, surely more selective than Fluoxetin.Altough in vivo it wins some in selectivity (see same link above).What I'm still missing is the claim for its DRI property in high doses and the alledged "push",maybe its also a metabolite responsible for it?One paper claimed an anti-pain effect,which is antagoniseable with Naloxone,how come that when it doesen't bind to opioid receptors?
 
I think you'll end up with serotonin syndrome before you have valuable DAT inhibition.
 
Cool list jasoncrest. I have tried Amantadine off-label for depression. It didn't help, but it did make me dizzy.

No one has mentioned Hydroxyzine (Vistaril), an antihistamine that has mild anxyolitic properties. Might be helpful.
 
hugo24 said:
Duloxetin weakkly blocks the Dopamin Transporter ( 240nm;0.8nm SERT,7.5nm NET) and inhibits DA uptake,maybe its sufficient clinically,at least it appears quite effective (personal experience,but f*** the withdrawal)

http://www.nature.com/npp/journal/v25/n6/full/1395741a.html

Desvenlafaxine (Pristiq) will come to market soon,but it appears more a patent related thing.Venlafaxine is still a bit a mystery to me,not really a SNRI,rather a SSRI, surely more selective than Fluoxetin.Altough in vivo it wins some in selectivity (see same link above).What I'm still missing is the claim for its DRI property in high doses and the alledged "push",maybe its also a metabolite responsible for it?One paper claimed an anti-pain effect,which is antagoniseable with Naloxone,how come that when it doesen't bind to opioid receptors?
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It's anti-nociceptive effect IS mediated by by kappa1- kappa3- and delta-opioid receptor subtypes. Here's some studies:

http://www.ncbi.nlm.nih.gov/pubmed/15157989

http://www.sciencedirect.com/scienc...serid=10&md5=e6bd783afea9c8e9a32d8444c2434665

A lot of other AD's have some mild opioid effects. Even Trazadone exerts an effect on both mu opioid receptors.
 
Well they had to find novel ones for me because I refuse SSRIs. I have Borderline as well, with a couple other listed disorders.
Wellbutrin worked for a year
then I was moved to a mood stabilizer used to treat sezuires, lamotrigine. It works...as long as I take it. lol.
 
i have been getting pretty interesting results from the atypical tricyclic AD tianeptine. the first time i took it, it gave me an incredible stupefying euphoria comparable to amphetamine and weed, for the first week of taking it i had to break the pills in half (6.25mg) if i wished to get work done because the euphoria was so distracting. the euphoriant effect is now almost gone at normal doses, but it still exerts a recognizable AD effect. experimentally after sustained use taineptine begins to act more like a classic SSRI...oh well.
 
I know it is hard but if you are aware of your problems then why can you not see this as you are doing it and challenge yourself (subconsciously) to omit the unwanted behavior? What is preventing you from trying to work to better your problem without having to take drugs all the time?
 
Borderline Personality Disorder is a VERY complex disorder to deal with and treat. You often can see what you are doing, after the fact, but you can't seem to help yourself. You don't know what else to do. BPD cannot be treated with medication alone, YEARS of painful therapy is needed and BPD patients are often resistant to change behaviors and view points that have sustained them, although miserably throughout their life. I don't think anyone that doesn't suffer from it can truly understand.
That is about all I will say simply because BPD isn't met with much sympathy or understanding on BL in my personal experience.
 
Pillthrill said:
Borderline Personality Disorder is a VERY complex disorder to deal with and treat. You often can see what you are doing, after the fact, but you can't seem to help yourself. You don't know what else to do. BPD cannot be treated with medication alone, YEARS of painful therapy is needed and BPD patients are often resistant to change behaviors and view points that have sustained them, although miserably throughout their life. I don't think anyone that doesn't suffer from it can truly understand.
That is about all I will say simply because BPD isn't met with much sympathy or understanding on BL in my personal experience.
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if it was easy to sort out a personality disorder by not doing certain things that would be nice. but most people arent robots who can destroy and replace their personality something more convenient. if it was that obvious for them to see where their logic has gone wrong then they would solve it , but they dont see it
 
hamhurricane said:
i have been getting pretty interesting results from the atypical tricyclic AD tianeptine. the first time i took it, it gave me an incredible stupefying euphoria comparable to amphetamine and weed, for the first week of taking it i had to break the pills in half (6.25mg) if i wished to get work done because the euphoria was so distracting. the euphoriant effect is now almost gone at normal doses, but it still exerts a recognizable AD effect. experimentally after sustained use taineptine begins to act more like a classic SSRI...oh well.
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I know it's meant to be an SSRE or whatever but try taking a large amount. It feels exactly the same as an opioid, but with a very short duration.
 
I know it is hard but if you are aware of your problems then why can you not see this as you are doing it and challenge yourself (subconsciously) to omit the unwanted behavior? What is preventing you from trying to work to better your problem without having to take drugs all the time?
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We are (thankfully) now in the age of biological psychiatry. Enlightened scientists presently understand that you cannot wish away or think away mental illness. Mild mental distress can be helped by certain kinds of therapy, but the psychological approach is now dated; we are slowly finding out than nearly ever disorder is "organic."

I know the issue is much more complex than that, but that's my assessment.
 
I major in psychology


as someone who suffers from clinical depression, and also being an advanced drug addict/user(lol), I can attest that gabapentin shows promise, at least at higher than usual doses



very little side effects, hard to overdose on - I swear it has been the only thing that has ever worked - I have been on every medicine in the book(exagerration, but at least a dozen antidepressants) I only even know this because I have neuropathy in my legs from a critical methadone overdose, so I was prescribed it - it has a great mood stabalizing(sp?) effect - If I could do a clinical trial right now I would bet money it would fair better than most anti-depressants on the market(most ssri/snri's)
 
hamhurricane said:
i have been getting pretty interesting results from the atypical tricyclic AD tianeptine. the first time i took it, it gave me an incredible stupefying euphoria comparable to amphetamine and weed, for the first week of taking it i had to break the pills in half (6.25mg) if i wished to get work done because the euphoria was so distracting.
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Fuck. That's depressing. What does it say about my basal hedonic tone that I have to take at least 62.5 mg (5 tablets) of Tianeptine to have an experience that were a mere shadow of the ones which you evidently have at 6.25 mg.

P.S. (I am on Clonazepam right now so my I express a far lower degree of diffidence and inhibition than I otherwise would; while sober, even I am not so effrontery as to submit a post that so ran against the grain of a thread as the following does. But I share this now not only because my inhibitions are lowered, but because it treats of an issue that has been eating away at me for years and I want to get it off of my chest.)

At this moment in time I can not well comprehend, on account of the slowness of the declension of my mental health, how much I have lost of the emotional depth and richness of my quondam state of being. Every now and again (twice a year or so) I have an experience characterized by the full restoration of my emotions - in degree and breadth. These experiences last generally a mere fraction of a second, but they are always followed by extreme terror and me screaming at the loudest possible volume out of a keenly painful recognition of how much I have lost and how unlikely it is that there should ever be a long-lasting revivification of my defunct internal life. When I was younger, if I would but close my eyes, suddenly I would observe the coalescence of a vale or tableau from the aether suffused with richness, lucidity, daedal complexity, color, and idyllic otherwordly beauty. This occurred without any real effort on my part at all. Now, when I close my eyes I see and feel only blackness, try as hard as I may to summon forth moving and palatable imagery.

Modern psychiatry, unfortunately, doesn't concern itself with the resolution of problems such as this - instead with bringing the patient to a state somewhere in the vicinity of average health, going no further than that if at all possible. As for me, I am at a total loss as to which receptors need to be agonized, which antagonized, and which brain structures need to be altered and in what way.

Ropinirole enhanced my emotions greatly - but what emotions I experienced were all overwhelmingly dark and dysphoric. And it did nothing to rectify the loss of my faculty of imagination.
 
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rocknroll714 said:
I'm probably a few years too late but.. here are some potential options for you:

* Adding dopaminergic reuptake inhibition to your current serotonin and norepinephrine reuptake inhibition. There's a reason why serotonin/norepinephrine reuptake inhibitors are so much less effective than the traditional MAOIs for treating anxiety and depression.. it's because of the lack of additional dopaminergic stimulation. If dopamine reuptake inhibition is added and along with serotonin and norepinephrine all three systems are generally balanaced, I'll bet such a combination would be right on par with an MAOI. Amineptine (maneon, survector), and bupropion (wellbutrin) are currently the only two available drugs that you could do this with. Bupropion is pretty weak so I don't really recommend it but I will say it's not completely useless. Amineptine is a wonderful drug and I'm sure it'd do the trick for you just right if you tried it. Since both bupropion and amineptine are weak on norepinephrine reuptake inhibition I'm pretty sure combining one of them with your effexor would be just fine. If not all you would have to do is switch to an SSRI instead however.

* Getting yourself an irreversible unselective MAOI. Either phenelzine (nardil), tranylcypromine (parnate), or isocarboxazid (marplan) is what you want. I would recommend nardil since you say social anxiety is your primary concern. Nardil is probably the most effective drug there is for social phobia. I went on it for a while myself and it was simply incredible. No shyness, no anxiety, no worries.. whatsoever. Just bliss with me and all my friends and everyone else. With your past drug history I'm sure you would have little difficulty getting a doc to prescribe it.

* Supposedly some guy took a bottle of buspirone (buspar) a day for a few months straight for social anxiolytic and antidepressant purposes. Not sure if I would recommend that or not but could be interesting. Buspirone is a 5-HT1A receptor agonist so it indirectly releases oxytocin and this is believed to cause the social disinhibition. It's theorized that MDMA causes it's empathogenic/entactogenic effects via the very same mechanism of action. So who knows could be worth a try.

* Last but certainly not least.. NMDA antagonist antidepressants. Ketamine works for you? Why not use it! Many people use sub-recreational doses (15 to 30 mg or so I believe) of ketamine every day for anxiety and depression and it works wonders for them. Just keep it on the down low of course. If ketamine isn't an option then I suppose amantadine or memantine off-label (as mentioned above) would be considerable choices instead.

Hope that helps.
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Do you think MAOIs like Parnate or Nardil effect dopamine at a greater level than DRIs like Wellbutrin or amineptine?

The only dopamine RE inhibitor thats on the market is bupropion. I don't think think survector is even in the US anymore. Mirapex is a dopamine agonist, but I haven't heard much about its antidepressant effects.
 
Anti depressants cure the symptoms of depression but not always the main cause in my opinion. They do work in the short term for sure (I've used citalopram, and its definately helped)

But if you want to get to the cause of your social anxiety and depression I highly recommend CBT or similar therapies, whether accompanied by anti-dep's or not. Also simple things like running every day and excersising, giving yourself one different goal to achieve every day, eating healthy food and improving your closeness to people and family that you are not too socially anxious around by opening up about things can help wonders in starting to overcome your social phobias that have built up with other certain people (I know this from experience). Also getting a girlfrined/boyfriend and a bit of love in your life is a miracle cure, but I fully appreciate not always easily attainable if your condition is related also to relationship issues (most are)

Hope that helps.
 
rocknroll714 said:
That's.. complicated. Wellbutrin, yes, since you can only dose it so high due to the norepinephrine and the seizure threshold. Amineptine.. very doubtful. Provided you dosed the MAOI high enough you could still get a very nice boost in dopamine, but nothing comparable to most reuptake inhibitors and releasers. Personally though I think extremely high dose rasagiline would be really sweet.
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I wish I could find something that shows the efficacy/affinity of bupropions dopamine effect compared to say, Parnate, Nardil or rasagiline. Rasagiline looks really interesting though apparently patients were able to take it with other antidepressants.

My depression is more dopamine related than seratonin. And since theres only one DNRI on the market(with the exception of MAOIs) for the US it is pretty limited for me. I just wish I could find something that has the antidepressant effect as speed does without the addiction and sides.

Mirapex looks interesting though.
 
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