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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

So I know there is no way to give a definite answer here, but I wanted to see if I could get a general opinion. I've been taking 450mg of Lyrica a day for three months. What are the chances that abrupt discontinuation would cause withdrawal and how severe would the withdrawal be?
 
DexyDevil said:
So I know there is no way to give a definite answer here, but I wanted to see if I could get a general opinion. I've been taking 450mg of Lyrica a day for three months. What are the chances that abrupt discontinuation would cause withdrawal and how severe would the withdrawal be?
Click to expand...

Very very slim... You haven’t taken it long enough.
 
S.M.F.G said:
^ what about in Austrailia?? i asked a few questions a few posts up..... id like to also know now if this is on PBS here in OZ:\
otherwise im pretty much fucked
Click to expand...

It is now on the PBS in NSW Australia fofr neuropathic pain. I know coz I got a box today with 5 repeats
 
I've been taking high-dose morphine and dihydrocodeine (Vicodin in US?) since a helicopter crash twenty years ago. Really bad nerve damage in lower spine.
My doc put me on Lyrica a couple of weeks ago and I'm frankly amazed at the results. Poured honey into my spine, kicked my depression and helped with the opiate withdrawal. Problem is, I've had to triple the initial daily dose of 300mg to get the same effect. Wickedly short tolerance period.
Are you sure about the increase in efficacy after only a day or so off?
I'm willing to grit my teeth for that amount of time if I get back that amazingly smooth relief I experienced initially.
Not quite the miracle panacea I thought it was, but damn close.
No-one seems to know why it does what it does, but I see a lot of potential before it gets classified as a 'controlled drug' which it probably will. :\
Anyway, can you confirm about the break?
Thanks mate.
 
I had my first dose of lyrica today. I only had 75mg however I am also on 160ml of methadone. Even on a dose of 75mg I felt very dreamy and very happy!
I will up the dose now.
It goes really well with methadone.
Happy customer.
 
Toranaga said:
I've been taking high-dose morphine and dihydrocodeine (Vicodin in US?) since a helicopter crash twenty years ago. Really bad nerve damage in lower spine.
My doc put me on Lyrica a couple of weeks ago and I'm frankly amazed at the results. Poured honey into my spine, kicked my depression and helped with the opiate withdrawal. Problem is, I've had to triple the initial daily dose of 300mg to get the same effect. Wickedly short tolerance period.
Are you sure about the increase in efficacy after only a day or so off?
I'm willing to grit my teeth for that amount of time if I get back that amazingly smooth relief I experienced initially.
Not quite the miracle panacea I thought it was, but damn close.
No-one seems to know why it does what it does, but I see a lot of potential before it gets classified as a 'controlled drug' which it probably will. :\
Anyway, can you confirm about the break?
Thanks mate.
Click to expand...

Yes, a break for about 24 hours makes the feeling come back. If you have been using it daily for a long time then maybe 48 hours the first time and then 24 hours after that. I am in 300 mg every other day.
 
Just want to say it has been added to the standard list of drug tests here now. It was the substance at the bottom of the ones to be crossed off for an urine sample. Gabapentin wasn't there but is so similar it might give up a positive.
 
Yes. It's obviously now been classified as a substance for recreational abuse, which it always has been. Much more than benzos are. Scandinavia, but no doubt the rest of the world will follow, or have started following.

It might not come up as a false positive, but the substances are so alike they might be able to gather you've been using that as well. I now see you also can't order Gabapentin online without a doctor's prescription anymore. Guess the fun is coming to an end for many.
 
^ Through daily, therapeutic usage, you quickly build a tolerance to the recreational aspects of Lyrica, and it becomes useless recreationally over time, even in megadoses, unlike benzos, where there is no ceiling dosage even with extreme tolerance. Benzos should be schedule III, and Lyrica deserves its mild schedule V rating, all imo of course.

Anyways, I came to this thread to commend Lyrica on its usage as an opiate withdrawal aid: it's amazing! I take 300mg every morning, but taking 600mg for 3 days after w/d, then 300mg daily after that really helps with w/d symptoms, for the few days I was w/d'ing from PST and couldn't get my hands on loperamide. I finally picked up some Lope, and with that and PG-P inhibitors (WGFJuice, Lansoprazole, etc, to make the lope cross the BBB) and the Lyrica, it completely erased all my opioid w/d symptoms, and actually gives me a very mild, opioid like high.
 
Almost none. Fairly low dose for three months? A couple of days of anxiety, easily handled with 10mg of any benzo will hold you.
Pregabalin is a very unusual drug. It's not retained by the body at all. In initial tests they found that 95% of the drug was recoverable in the urine after 24hrs.
Any withdrawal will be purely psychological.
 
You're absolutely right! I've been taking high doses of morphine, codeine, and benzos for nigh-on twenty years now. I thought I'd never find anything to stop the terrible withdrawal every time I tried to quit. But pregabalin is like a miracle drug. It affects the same bunch of nerves in the lower spine, effectively cutting off the channels they use to 'speak' to the brain. These same nerves undergo an unnatural thickening with heroin and opiate use in general over time and they scream when you stop taking these opiates. Causing all the familiar withdrawal-symptoms.
150mg twice a day, and after only three weeks I no longer need the Vicodin.
 
ErgicMergic said:
^ Through daily, therapeutic usage, you quickly build a tolerance to the recreational aspects of Lyrica, and it becomes useless recreationally over time, even in megadoses
Click to expand...

This is not the case. Like other have said the very simple secret to recreational use is to take a day or two off. After 3 days tolerance seems to be gone completely.
 
Toranaga said:
Almost none. Fairly low dose for three months? A couple of days of anxiety, easily handled with 10mg of any benzo will hold you.
Pregabalin is a very unusual drug. It's not retained by the body at all. In initial tests they found that 95% of the drug was recoverable in the urine after 24hrs.
Any withdrawal will be purely psychological.
Click to expand...

What does that have to do with withdrawal? Marijuana stays in the body for weeks but you don't have physical withdrawals from it. Pregabalin being recoverable in urine doesn't mean it can't produce physical dependency. I don't understand your logic here. Could you explain a bit more?
 
Ninae said:
This is not the case. Like other have said the very simple secret to recreational use is to take a day or two off. After 3 days tolerance seems to be gone completely.
Click to expand...

Agreed. Plus I take 450mg per day in divided doses, but if I take 600mg all at once I can trip pretty hard, without even skipping days. Now if I take 600mg at once the very next day the effect will be greatly diminished.

I wouldn't trade my Lyrica script for any benzo script, even flunitrazepam. Daily benzo use truly does make them completely useless recreationally for me. This is far from the case with Lyrica. Besides, it is extremely therapeutic for me.
 
Sorry. I meant that pregabalin isn't metabolised at all. Unlight some drugs whos residuals cause actual physical dependance.
Is that any clearer? I'm rather new at discussions on forums of this sort. It's a slow way of explaining anything. :/
 
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