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  • BDD Moderators: Keif’ Richards

Oxycodone (ER/CR) w/ Naloxone

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toobent

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Dec 19, 2010
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I've been prescribed Targin (20mg ER Oxycodone combined with 10mg Naloxone) for extended pain relief, to be taken consistently with my Endone (5mg Oxycodone) to be used for breakthrough (instant) pain relief during acute, severe onset of pain. I have ran out of this script of Endone and am not due for another for 3 days and am experiencing some severe (Px 9-10) pain today. The Targin is not providing any pain relief at all! So I have two questions:

1. Can crushing the Targin tablet in to fine powder and drinking with a glass of water reduce the Extended Release component of the Oxycodone to provide effective pain relief?

2. Can crushing the Targin tablet and parachuting the fine powder reduce or eliminate the Extended Release mechanism to provide breakthrough effective pain relief?

2. Can I somehow CWE the Oxycodone from the Naloxone, or via some other extraction method (acetone?) to administer a higher dose of Oxycodone without the opioid blocking effect from the Naloxone?

Please provide responses ASAP. I am in tremendous pain right now. Unable to remove myself from bed, and psychologically distraught. Thank you.
 
Sorry about your situation :(

I'm not sure about crushing it and taking it orally as far as how effective that is at defeating the time release, sorry.

toobent said:
2. Can I somehow CWE the Oxycodone from the Naloxone, or via some other extraction method (acetone?) to administer a higher dose of Oxycodone without the opioid blocking effect from the Naloxone?
Click to expand...

No, both oxycodone and naloxone are very water soluble, so a CWE wouldn't work. I have no idea if there is some other way to extract the oxycodone.
 
Thanks for responding quickly.

I'm just going to crush one Targin and ingest it with a small amount of coconut oil in an attempt to enchance (oxycodone's lipid solubility) it's effect, and swallow one Targin whole at the same time.

I was considering rectal administration but than the Naloxone might antagonize the opioid as it won't be ( 98% ) eliminated through the GI and first pass, hence weakening or eliminating the analgesic effect of the Oxycodone.

Damn these pharmaceuticals producing useless medications that Physician's favour!
 
^ That sounds like a good experiment. It will either work completely, to a lesser degree, or just release as usual so you've got nothing to lose.

I would stay away from plugging for the reason you mentioned. Kind of defeats the point.
 
Venrak said:
^ That sounds like a good experiment. It will either work completely, to a lesser degree, or just release as usual so you've got nothing to lose.

I would stay away from plugging for the reason you mentioned. Kind of defeats the point.
Click to expand...

It worked, and worked very well. The following process:

toobent said:
I'm just going to crush one Targin and ingest it with a small amount of coconut oil in an attempt to enchance (oxycodone's lipid solubility) it's effect, and swallow one Targin whole at the same time.
Click to expand...

Provided very good analgesic effect within ~30 minutes of administration, and the relief was sustained for a good 5 hours before I noticed a gradual return of pain, but did not redose as I am trying to taper off the Oxycodone.
 
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