For a moderator, you're quite the immature prick. You're giving bad HR advice solely based on your opinion, and make no disclaimer to that effect. You should acknowledge that I have a point, that we don't know what could happen, but you're trying to shoot me down. How did you get the job man, seriously?
Are you a healthcare professional with an intimate knowledge of different psychedelics' binding affinities and their impact on the cardiovascular system? (I'm taking the liberty of making that a rhetorical question btw).
There's a difference between sitting quietly and running a fucking marathon, isn't there? 5k isn't "running down the street". It's five kilometres. And while the marathon isn't about setting records it still involves running, for quite a while. I couldn't run 400m, let alone 5k. You could be a bit more mature, sensible and HR-oriented and, rather than try and shoot me down with absurd comments like "it's just your opinion, man" and "If taking a psychedelic the one day it's OK to run down the street and throw paint on strangers is wrong then I don't want to be right", you could tell the OP that, since 25i-NBOMe has already caused a few more than unpleasant accidents (this isn't "opinion" by the way, I, out of the two of us, am the sole one supporting his assertions with fact) and carries significant body-load with circulatory and cardiovascular issues, has high affinity for the serotonin receptor most associated with heart valve problems, so if he does indeed intend to go through with it, it would be best not to run but keep as leisurely a pace as possible. Or better yet, switch to a drug with less body-load, since 25i-NBOMe has already caused quite a few fuck-ups and a few deaths (people not running, but "sitting quietly").
Realistically, I don't expect the OP's heart to explode out of his chest and die, but it's, arguably, your job as a moderator on an HR site to make him aware of the potential health risks he is running. Like, mention the shit I just did, so he can make a more informed decision as to his safety, not shoot me down when I'm giving valid, factual information that could aid him in choosing what substance to take, and how to act when on said substance.
Tosser.