applescherrys88
Greenlighter
Hi I was just wondering if someone could give me an idea of how long after taking tramadol can I take adderall without them interacting with each other too much. Any ideas would be great, thanks.
So if tramadol lasts 4-6 hours does that mean I can take another dose then? And if I wait an hour after taking the tramadol and its not helping much can I take one more then? I was trying to find this all over the web but all I kept finding was its half life or how much to take in one dose, not if I could add to that dose. Any help would be much appreciated, as is the advice you already gave. Thanks again.
In my experience, tramadol's effects (IR) can last up to about 8 hours. I'd wait 12 hours before redosing after a full dose. For tramadol, working your way up with the dose is more effective because already having tramadol in your system will increase the metabolization of tramadol into O-desmethyltramadol for the next dose you take. (O-DT is a far more potent chemical than tramadol with far more mu-agonism, about ~10% of the tramadol is converted to O-DT in the liver.)
I'd wait 24 hrs because tramadol has an intermediate halfofe ans so does its metabolite. The reason it is bad to take the two together is because they both release serotonin and both increase norepinephrine levels. This means the two could causs a fatal and sudden effect called serotonin syndrome. The norepinephrine combo would also make you feel squirny and over stimulated, it won't be fun. Also both reduce the seizure threshold meaning it is very likely you could experience a grand mal seizurr. Also amphetamines are a substrate of the liver enzyme 2D6 which is the same enzyme thT metabolizes tramadol into the good shit o desmethyltramadol which accounts for the main opiate effects of tramadol. The amps will effectively clog this enzyme and as a result your body will notl produce odesmethyltram
at an optimal level
Those are multiple reasons to wait a good day before taking either one. If you take addy, wait a day to take tram, and if you take tram wait a day before addy.